Biophysics

  1. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

    1. Meghna Gupta
    2. Caleigh M. Azumaya
    3. Michelle Moritz
    4. Sergei Pourmal
    5. Amy Diallo
    6. Gregory E. Merz
    7. Gwendolyn Jang
    8. Mehdi Bouhaddou
    9. Andrea Fossati
    10. Axel F. Brilot
    11. Devan Diwanji
    12. Evelyn Hernandez
    13. Nadia Herrera
    14. Huong T. Kratochvil
    15. Victor L. Lam
    16. Fei Li
    17. Yang Li
    18. Henry C. Nguyen
    19. Carlos Nowotny
    20. Tristan W. Owens
    21. Jessica K. Peters
    22. Alexandrea N. Rizo
    23. Ursula Schulze-Gahmen
    24. Amber M. Smith
    25. Iris D. Young
    26. Zanlin Yu
    27. Daniel Asarnow
    28. Christian Billesbølle
    29. Melody G. Campbell
    30. Jen Chen
    31. Kuei-Ho Chen
    32. Un Seng Chio
    33. Miles Sasha Dickinson
    34. Loan Doan
    35. Mingliang Jin
    36. Kate Kim
    37. Junrui Li
    38. Yen-Li Li
    39. Edmond Linossi
    40. Yanxin Liu
    41. Megan Lo
    42. Jocelyne Lopez
    43. Kyle E. Lopez
    44. Adamo Mancino
    45. Frank R. Moss
    46. Michael D. Paul
    47. Komal Ishwar Pawar
    48. Adrian Pelin
    49. Thomas H. Pospiech
    50. Cristina Puchades
    51. Soumya Govinda Remesh
    52. Maliheh Safari
    53. Kaitlin Schaefer
    54. Ming Sun
    55. Mariano C Tabios
    56. Aye C. Thwin
    57. Erron W. Titus
    58. Raphael Trenker
    59. Eric Tse
    60. Tsz Kin Martin Tsui
    61. Feng Wang
    62. Kaihua Zhang
    63. Yang Zhang
    64. Jianhua Zhao
    65. Fengbo Zhou
    66. Yuan Zhou
    67. Lorena Zuliani-Alvarez
    68. QCRG Structural Biology Consortium
    69. David A Agard
    70. Yifan Cheng
    71. James S Fraser
    72. Natalia Jura
    73. Tanja Kortemme
    74. Aashish Manglik
    75. Daniel R. Southworth
    76. Robert M Stroud
    77. Danielle L Swaney
    78. Nevan J Krogan
    79. Adam Frost
    80. Oren S Rosenberg
    81. Kliment A Verba

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies

    1. Yiwei Cao
    2. Yeol Kyo Choi
    3. Martin Frank
    4. Hyeonuk Woo
    5. Sang-Jun Park
    6. Min Sun Yeom
    7. Chaok Seok
    8. Wonpil Im

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. The Role of Host Cell Glycans on Virus Infectivity: The SARS‐CoV‐2 Case

    1. Silvia Acosta‐Gutiérrez
    2. Joseph Buckley
    3. Giuseppe Battaglia

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Vitamin C Binds to SARS Coronavirus-2 Main Protease Essential for Viral Replication

    1. Tek Narsingh Malla
    2. Suraj Pandey
    3. Luis Aldama
    4. Dennisse Feliz
    5. Moraima Noda
    6. Ishwor Poudyal
    7. George N. Phillips
    8. Emina A. Stojković
    9. Marius Schmidt

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

    1. Lorena Zuzic
    2. Firdaus Samsudin
    3. Aishwary T. Shivgan
    4. Palur V. Raghuvamsi
    5. Jan K. Marzinek
    6. Alister Boags
    7. Conrado Pedebos
    8. Nikhil K. Tulsian
    9. Jim Warwicker
    10. Paul MacAry
    11. Max Crispin
    12. Syma Khalid
    13. Ganesh S. Anand
    14. Peter J. Bond

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M pro )

    1. Ali Ebrahim
    2. Blake T. Riley
    3. Desigan Kumaran
    4. Babak Andi
    5. Martin R. Fuchs
    6. Sean McSweeney
    7. Daniel A. Keedy

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Binding of SARS-CoV-2 fusion peptide to host membranes

    1. Stefan L. Schaefer
    2. Hendrik Jung
    3. Gerhard Hummer

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Solubility product constant directs the formation of biomolecular condensates

    1. Aniruddha Chattaraj
    2. Michael L. Blinov
    3. Leslie M. Loew

    • Curated by eLife

      Evaluation Summary:

      Recent experiments have raised questions regarding concentration buffering provided by the formation of multicomponent biomolecular condensates via phase separation driven by heterotypic interactions. In this work, Chattaraja et al., demonstrate that the concept of a solubility product, used to describe the solubility limits of ionic solutions, sets an upper limit on concentration thresholds, even in systems where the driving forces for phase separation are primarily heterotypic in nature. Their work suggests that the concept of a solubility product rescues the concept of buffering via phase separation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  9. Python-Microscope – a new open-source Python library for the control of microscopes

    1. David Miguel Susano Pinto
    2. Mick A. Phillips
    3. Nicholas Hall
    4. Julio Mateos-Langerak
    5. Danail Stoychev
    6. Tiago Susano Pinto
    7. Martin J. Booth
    8. Ilan Davis
    9. Ian M. Dobbie

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide

    1. George Khelashvili
    2. Ambrose Plante
    3. Milka Doktorova
    4. Harel Weinstein

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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