Biophysics

Structure and Dynamics of RNA Guanine Quadruplexes in SARS-CoV-2 Genome. Original Strategies against Emerging Viruses

1. Tom Miclot
2. Cécilia Hognon
3. Emmanuelle Bignon
4. Alessio Terenzi
5. Marco Marazzi
6. Giampaolo Barone
7. Antonio Monari

Reviewed by ScreenIT

Water-Triggered, Irreversible Conformational Change of SARS-CoV-2 Main Protease on Passing from the Solid State to Aqueous Solution

1. Narjes Ansari
2. Valerio Rizzi
3. Paolo Carloni
4. Michele Parrinello

Reviewed by ScreenIT

Role of ATP in the RNA Translocation Mechanism of SARS-CoV-2 NSP13 Helicase

1. Ryan Weber
2. Martin McCullagh

Reviewed by ScreenIT

Fluorescence signatures of SARS-CoV-2 spike S1 proteins and a human ACE-2: excitation-emission maps and fluorescence lifetimes

1. Jonas Grzesiak
2. Lea Fellner
3. Karin Grünewald
4. Christoph Kölbl
5. Arne Walter
6. Reinhold Horlacher
7. Frank Duschek

Reviewed by ScreenIT

Landscape-Based Mutational Sensitivity Cartography and Network Community Analysis of the SARS-CoV-2 Spike Protein Structures: Quantifying Functional Effects of the Circulating D614G Variant

1. Gennady M. Verkhivker
2. Steve Agajanian
3. Deniz Yasar Oztas
4. Grace Gupta

Reviewed by ScreenIT

Presence of a SARS-COV-2 protein enhances Amyloid Formation of Serum Amyloid A

1. Asis K. Jana
2. Augustus B. Greenwood
3. Ulrich H. E. Hansmann

Reviewed by ScreenIT

Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodies

1. Erik Laurini
2. Domenico Marson
3. Suzana Aulic
4. Alice Fermeglia
5. Sabrina Pricl

Reviewed by ScreenIT

Structural intermediates observed only in intact Escherichia coli indicate a mechanism for TonB-dependent transport

1. Thushani D Nilaweera
2. David A Nyenhuis
3. David S Cafiso

• Curated by eLife

  Evaluation Summary:

  The manuscript endeavors to explain the mechanism of action of the gram-negative bacterial outer membrane TonB-dependent transporter BtuB, which acquires vitamin B12 from the external environment. The authors use electron paramagnetic resonance spectroscopy to monitor the proximity of different parts of this protein to one another during the binding of B12 directly in the E. coli outer membrane. This manuscript will be of interest to those who study the biophysics of membrane transporters and stresses the importance of studying membrane proteins in their native environment.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53

1. Kaushik Inamdar
2. Feng-Ching Tsai
3. Rayane Dibsy
4. Aurore de Poret
5. John Manzi
6. Peggy Merida
7. Remi Muller
8. Pekka Lappalainen
9. Philippe Roingeard
10. Johnson Mak
11. Patricia Bassereau
12. Cyril Favard
13. Delphine Muriaux

• Curated by eLife

  Evaluation Summary:

  This manuscript combines cell biology, biochemistry, and quantitative biophysics to understand a new host cell factor, the human I-BAR domain protein IRSp53, promotes HIV type 1 (HIV-1) assembly and release. Since this new factor is a protein involved in the generation and sensing of negative membrane curvature, this manuscript will be of interest not only for retrovirologists and virologists in general but also for membrane biologists and biophysicists.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

in silico Assessment of Antibody Drug Resistance to Bamlanivimab of SARS-CoV-2 Variant B.1.617

1. Leili Zhang
2. Tien Huynh
3. Binquan Luan

Reviewed by ScreenIT