Biophysics

  1. Conformational Changes of the ABC Transporter BmrA Depend on Membrane Curvature

    1. Alicia Damm
    2. Kemil Belhadji
    3. Raj Kumar Sadhu
    4. Su-Jin Paik
    5. Aurélie Di-Cicco
    6. John Manzi
    7. Michele Castellana
    8. Raju Regmi
    9. Emmanuel Margeat
    10. Maxime Dahan
    11. Pierre Sens
    12. Daniel Lévy
    13. Patricia Bassereau

    • Curated by eLife

      eLife Assessment

      This valuable study investigates whether the activity of an ABC transporter, BmrA, can be modulated by mechanical stimuli. The authors develop a single-molecule experimental system to address this question, although aspects of the methodological framework are incomplete. This work also develops a convincing theoretical model to explain the effect of membrane curvature on the conformational transitions observed during the activity cycle of this membrane protein. This study is of interest to the fields of membrane biophysics and membrane transport.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  2. Invasive cancer cells soften collagen networks and disrupt stress-stiffening via volume exclusion, contractility and adhesion

    1. Irène Nagle
    2. Margherita Tavasso
    3. Ankur D. Bordoloi
    4. Iain A.A. Muntz
    5. Gijsje H. Koenderink
    6. Pouyan E. Boukany

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Interplay Between Pulmonary Membrane Properties and Lung Disease: A Study of Seven Bottlenose Dolphins

    1. Marilyn Porras-Gómez
    2. Bengu Sueda Sengul
    3. Nurila Kambar
    4. Sari Gluck
    5. Kristen Flatt
    6. Celeste Parry
    7. Carolina Ruiz Le-Bert
    8. Diego Hernández-Saavedra
    9. Cecília Leal

    • Curated by eLife

      eLife Assessment

      The study presents data on the possible connection of respiratory pathologies like pneumonia in a cohort of dolphins with altered composition and concomitant perturbed biophysical properties of pulmonary surfactant complexes. Overall, it is a valuable contribution that could be of interest to scientists in the field. However, the study as it is appears somewhat incomplete and additional clarification and discussions are required in order to explain a few methodological questions that may limit the impact of the work considerably.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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