Biophysics

Intracellular mechanical fingerprint reveals cell type specific mechanical tuning

1. Till M. Muenker
2. Bart E. Vos
3. Timo Betz

• Curated by eLife

  eLife assessment

  Münker and colleagues use an optical tweezer setup to apply oscillatory forces to endocytosed/phagocytosed glass beads over a wide frequency range (from ~1 to 1000 Hz) and probe cytoplasmic material properties at multiple time scales in six different cell types. Using statistical methods and principal component analysis, they find that the active and passive mechanical properties of cells can be described by 6 parameters (from power law fits) that allow characterizing the viscous and elastic nature of the cytoplasmic material as well as an effective active energy driven by cellular metabolism. Overall, this is very well done and important work, using convincing and state-of-the-art methods, albeit with some limitations related to the way the beads are internalized.

Reviewed by eLife

Sequence, structure, and affinity of miR-34a binding sites determine repression efficacy

1. Lara Sweetapple
2. David M Kosek
3. Elnaz Banijamali
4. Walter Becker
5. Juliane Müller
6. Christina Karadiakos
7. Lorenzo Baronti
8. Ileana Guzzetti
9. Dimitri Schritt
10. Alan Chen
11. Emma R Andersson
12. Katja Petzold

Reviewed by Review Commons

Cohesin distribution alone predicts chromatin organization in yeast via conserved-current loop extrusion

1. Tianyu Yuan
2. Hao Yan
3. Kevin C. Li
4. Ivan Surovtsev
5. Megan C. King
6. Simon G. J. Mochrie

Reviewed by Review Commons

PatternJ: an ImageJ toolset for the automated and quantitative analysis of regular spatial patterns found in sarcomeres, axons, somites, and more

1. Mélina Baheux Blin
2. Vincent Loreau
3. Frank Schnorrer
4. Pierre Mangeol

Reviewed by Review Commons

Active mechanics of sea star oocytes

1. Peter J. Foster
2. Alexandra Zampetaki
3. Jinghui Liu
4. Sebastian Fürthauer
5. Nikta Fakhri

Reviewed by PREreview

Amyloid Accelerator Polyphosphate Implicated as the Mystery Density in α-Synuclein Fibrils

1. Philipp Huettemann
2. Pavithra Mahadevan
3. Justine Lempart
4. Eric Tse
5. Budheswar Dehury
6. Brian F. P. Edwards
7. Daniel R. Southworth
8. Bikash R. Sahoo
9. Ursula Jakob

Reviewed by Arcadia Science