Biophysics

AlphaFold-SFA: accelerated sampling of cryptic pocket opening, protein-ligand binding and allostery by AlphaFold, slow feature analysis and metadynamics

1. Shray Vats
2. Raitis Bobrovs
3. Pär Söderhjelm
4. Soumendranath Bhakat

Reviewed by Biophysics Colab

Live imaging of Alu elements reveals non-uniform euchromatin dynamics coupled to transcription

1. Yi-Che Chang
2. Sofia A. Quinodoz
3. Clifford P. Brangwynne

• Curated by eLife

  eLife assessment

  This valuable study establishes a method for live-cell imaging, tracking, and quantification of Alu elements marking euchromatic regions of the nucleus. The method will help characterize the relationship between chromatin dynamics and transcriptional activity. While the findings are largely consistent with previous reports, characterization of the technique is incomplete and could benefit from additional controls.

Reviewed by eLife

Sequence, structure, and affinity of miR-34a binding sites determine repression efficacy

1. Lara Sweetapple
2. David M Kosek
3. Elnaz Banijamali
4. Walter Becker
5. Juliane Müller
6. Christina Karadiakos
7. Lorenzo Baronti
8. Ileana Guzzetti
9. Dimitri Schritt
10. Alan Chen
11. Emma R Andersson
12. Katja Petzold

Reviewed by Review Commons

Cohesin distribution alone predicts chromatin organization in yeast via conserved-current loop extrusion

1. Tianyu Yuan
2. Hao Yan
3. Kevin C. Li
4. Ivan Surovtsev
5. Megan C. King
6. Simon G. J. Mochrie

Reviewed by Review Commons

PatternJ: an ImageJ toolset for the automated and quantitative analysis of regular spatial patterns found in sarcomeres, axons, somites, and more

1. Mélina Baheux Blin
2. Vincent Loreau
3. Frank Schnorrer
4. Pierre Mangeol

Reviewed by Review Commons