Bioengineering

Calibration and validation strategy for electromechanical cardiac digital twins

1. Zhinuo Jenny Wang
2. Maxx Holmes
3. Ruben Doste
4. Julia Camps
5. Francesca Margara
6. Mariano Vazquez
7. Blanca Rodriguez

• Curated by eLife

  eLife Assessment

  This is a potentially important study that explores the relevant range of parameter values for calibration and validation of cardiac electromechanics in ventricular models. Although much of the work presented is solid, the evidence provided to support the authors' key scientific claims is incomplete, especially as it relates to the emphasis on standardized validation and verification approaches. Notably, the level of model personalization presented in this work falls short of the threshold for what could reasonably be called a "digital twin", even by the relatively relaxed standards that have emerged in computational physiology and related fields in recent years.

Reviewed by eLife

Bacterial Wastewater-Based Epidemiology Using Surface-Enhanced Raman Spectroscopy and Machine Learning

1. Liam K. Herndon
2. Yirui Zhang
3. Fareeha Safir
4. Babatunde Ogunlade
5. Halleh B. Balch
6. Alexandria B. Boehm
7. Jennifer A. Dionne

Reviewed by Arcadia Science

Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

1. M Reza Bahranifard
2. Jessica Chan
3. A Thomas Read
4. Guorong Li
5. Lin Cheng
6. Babak N Safa
7. Seyed Mohammad Siadat
8. Anamik Jhunjhunwala
9. Hans E Grossniklaus
10. Stanislav Y Emelianov
11. W Daniel Stamer
12. Markus H Kuehn
13. C Ross Ethier

• Curated by eLife

  eLife Assessment

  This study has fundamental findings that support the potential application of exogenous stem cell therapy as a viable therapeutic option for the management of intraocular pressure (IOP) and to increase outflow facility. The evidence supporting the clinical application of stem cells is compelling, using a combination of established in vivo and ex vivo experimental techniques. The work will be of interest to both basic stem cell biologists and clinical glaucoma specialists.

Reviewed by eLife

AI.zymes: A Modular Platform for Evolutionary Enzyme Design

1. Lucas P. Merlicek
2. Jannik Neumann
3. Abbie Lear
4. Vivian Degiorgi
5. Moor M. de Waal
6. Tudor‐Stefan Cotet
7. Adrian J. Mulholland
8. H. Adrian Bunzel

Reviewed by Arcadia Science

Antibody affinity engineering using antibody repertoire data and machine learning

1. Lena Erlach
2. Simon Friedensohn
3. Daniel Neumeier
4. Derek M. Mason
5. Sai T. Reddy

Reviewed by Arcadia Science

3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function

1. GaYoung Park
2. Josh A. Grey
3. Foteini Mourkioti
4. Woojin M. Han

Reviewed by preLights

Heart Scar-In-A-Dish: Tissue Culture Platform to Study Myocardial Infarct Healing In Vitro

1. MJ Potter
2. JD Heywood
3. SJ Coeyman
4. WJ Richardson

Reviewed by preLights

Toward De Novo Protein Design from Natural Language

1. Fengyuan Dai
2. Shiyang You
3. Yudian Zhu
4. Yuan Gao
5. Lihao Fu
6. Xibin Zhou
7. Jin Su
8. Chentong Wang
9. Yuliang Fan
10. Xiaoxiao Ma
11. Xianjun Deng
12. Letong Yu
13. Hui Qian
14. Yan He
15. Yitao Ke
16. Chenchen Han
17. Xing Chang
18. Liangzhen Zheng
19. Sheng Wang
20. Yajie Wang
21. Anping Zeng
22. Shunzhi Wang
23. Tong Si
24. Jianming Liu
25. Hongyuan Lu
26. Fajie Yuan

Reviewed by Arcadia Science

Self-Organizing Neural Networks in Novel Moving Bodies: Anatomical, Behavioral, and Transcriptional Characterization of a Living Construct with a Nervous System

1. Haleh Fotowat
2. Laurie O’Neill
3. Léo Pio-Lopez
4. Megan Sperry
5. Patrick Erickson
6. Tiffany Lin
7. Michael Levin

Reviewed by Arcadia Science

Free‐Form Microfluidic Microneedle Array Patches

1. Ian A. Coates
2. Madison M. Driskill
3. Netra U. Rajesh
4. Gabriel Lipkowitz
5. Dan Ilyn
6. Yue Xu
7. Maria T. Dulay
8. Gunilla B. Jacobson
9. John R. Tumbleston
10. Jillian L. Perry
11. Shaomin Tian
12. Joseph M. DeSimone

Reviewed by Arcadia Science