1. Development of antigen-dextramers for detection and evaluation of CAR T cells

    This article has 8 authors:
    1. Rasmus U. W. Friis
    2. Maria Ormhøj
    3. Cecilie S. Krüger-Jensen
    4. Markus Barden
    5. Keerthana Ramanathan
    6. Mikkel R. Hansen
    7. Hinrich Abken
    8. Sine R. Hadrup

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Lab-in-the-loop therapeutic antibody design with deep learning

    This article has 63 authors:
    1. Nathan C. Frey
    2. Isidro Hötzel
    3. Samuel D. Stanton
    4. Ryan Kelly
    5. Robert G. Alberstein
    6. Emily Makowski
    7. Karolis Martinkus
    8. Daniel Berenberg
    9. Jack Bevers
    10. Tyler Bryson
    11. Pamela Chan
    12. Alicja Czubaty
    13. Tamica D’Souza
    14. Henri Dwyer
    15. Anna Dziewulska
    16. James W. Fairman
    17. Allen Goodman
    18. Jennifer Hofmann
    19. Henry Isaacson
    20. Aya Ismail
    21. Samantha James
    22. Taylor Joren
    23. Simon Kelow
    24. James R. Kiefer
    25. Matthieu Kirchmeyer
    26. Joseph Kleinhenz
    27. James T. Koerber
    28. Julien Lafrance-Vanasse
    29. Andrew Leaver-Fay
    30. Jae Hyeon Lee
    31. Edith Lee
    32. Donald Lee
    33. Wei-Ching Liang
    34. Joshua Yao-Yu Lin
    35. Sidney Lisanza
    36. Andreas Loukas
    37. Jan Ludwiczak
    38. Sai Pooja Mahajan
    39. Omar Mahmood
    40. Homa Mohammadi-Peyhani
    41. Santrupti Nerli
    42. Ji Won Park
    43. Jaewoo Park
    44. Stephen Ra
    45. Sarah Robinson
    46. Saeed Saremi
    47. Franziska Seeger
    48. Imee Sinha
    49. Anna M. Sokol
    50. Natasa Tagasovska
    51. Hao To
    52. Edward Wagstaff
    53. Amy Wang
    54. Andrew M. Watkins
    55. Blair Wilson
    56. Shuang Wu
    57. Karina Zadorozhny
    58. John Marioni
    59. Aviv Regev
    60. Yan Wu
    61. Kyunghyun Cho
    62. Richard Bonneau
    63. Vladimir Gligorijević

    Reviewed by Arcadia Science

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery

    This article has 6 authors:
    1. Christian D Mutti
    2. Lindsey Van Haute
    3. Lucia Luengo-Gutierrez
    4. Keira Turner
    5. Pedro Silva-Pinheiro
    6. Michal Minczuk
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors have demonstrated the use of adenine base editors delivered via adeno-associated viruses to introduce edits in the mitochondrial genome. The manuscript describes the methodology well, and the conclusions are convincingly supported by the results. The valuable results highlight the potential of these base editors to model mtDNA variations in somatic tissues in animal models.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. Scaly-Tail Organ Enhances Static Stability during Pel’s Scaly-tailed Flying Squirrels’ Arboreal Locomotion

    This article has 6 authors:
    1. Andrew K. Schulz
    2. Mrudul Chellapurath
    3. Pranav C. Khandelwal
    4. SeyedReza Rezaei
    5. Stefan Merker
    6. Ardian Jusufi

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. Semantical and geometrical protein encoding toward enhanced bioactivity and thermostability

    This article has 5 authors:
    1. Yang Tan
    2. Bingxin Zhou
    3. Lirong Zheng
    4. Guisheng Fan
    5. Liang Hong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      ProtSSN is a valuable approach that generates protein embeddings by integrating sequence and structural information, demonstrating improved prediction of mutation effects on thermostability compared to competing models. The evidence supporting the authors' claims is compelling, with well-executed comparisons. This work will be of particular interest to researchers in bioinformatics and structural biology, especially those focused on protein function and stability.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  6. DyAb: sequence-based antibody design and property prediction in a low-data regime

    This article has 16 authors:
    1. Joshua Yao-Yu Lin
    2. Jennifer L. Hofmann
    3. Andrew Leaver-Fay
    4. Wei-Ching Liang
    5. Stefania Vasilaki
    6. Edith Lee
    7. Pedro O. Pinheiro
    8. Natasa Tagasovska
    9. James R. Kiefer
    10. Yan Wu
    11. Franziska Seeger
    12. Richard Bonneau
    13. Vladimir Gligorijevic
    14. Andrew Watkins
    15. Kyunghyun Cho
    16. Nathan C. Frey

    Reviewed by Arcadia Science

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Gut-on-Chip Methodology Based on 3D-Printed Molds: A Cost-Effective and Accessible Approach

    This article has 5 authors:
    1. Elise Delannoy
    2. Aurélie Burette
    3. Sébastien Janel
    4. Catherine Daniel
    5. Alexandre Grassart

    Reviewed by Arcadia Science

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  8. Discovery of Expression-Governing Residues in Proteins

    This article has 7 authors:
    1. Fan Jiang
    2. Mingchen Li
    3. Banghao Wu
    4. Liang Zhang
    5. Bozitao Zhong
    6. Yuanxi Yu
    7. Liang Hong

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. AI-enabled alkaline-resistant evolution of protein to apply in mass production

    This article has 10 authors:
    1. Liqi Kang
    2. Banghao Wu
    3. Bingxin Zhou
    4. Pan Tan
    5. Yun (Kenneth) Kang
    6. Yongzhen Yan
    7. Yi Zong
    8. Shuang Li
    9. Zhuo Liu
    10. Liang Hong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work demonstrates the application of Pro-PRIME, a large language model, to engineer VHH antibodies with enhanced stability for extreme industrial environments. The evidence is convincing, showing through two rounds of design and experimental validation that AI-guided approaches can outperform traditional rational design methods. The solid methodology and results establish a foundation for further exploration of LLM-assisted protein engineering.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

    This article has 13 authors:
    1. Sujeethkumar Prithiviraj
    2. Alejandro Garcia Garcia
    3. Karin Linderfalk
    4. Bai Yiguang
    5. Sonia Ferveur
    6. Ludvig Nilsén Falck
    7. Agatheeswaran Subramaniam
    8. Sofie Mohlin
    9. David Hidalgo Gil
    10. Steven J Dupard
    11. Dimitra Zacharaki
    12. Deepak Bushan Raina
    13. Paul E Bourgine
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study presents a potentially valuable approach to genetically modify cells to produce extracellular matrices with altered compositions, termed cell-laid, engineered extracellular matrices (eECM). The evidence supporting the authors' conclusions regarding the utility of eECM for endogenous repair is solid, although there are some disagreements on the chondrogenicity of lyophilized constructs which was viewed as lacking robust evidence for endochondral ossification.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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