Bioengineering

Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain

1. Mitul Desai
2. Jitendra Sharma
3. Adrian L Slusarczyk
4. Ashley A Chapin
5. Robert Ohlendorf
6. Agata Wisniowska
7. Mriganka Sur
8. Alan Jasanoff

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to readers in the field of magnetic resonance imaging and responsive imaging probes. In this work, a new imaging probe is designed and applied in proof-of-principle animal models, with future promise for relevance in models that have higher relevance to human disease.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids

1. Jessica M. Vanslambrouck
2. Sean B. Wilson
3. Ker Sin Tan
4. Ella Groenewegen
5. Rajeev Rudraraju
6. Jessica Neil
7. Kynan T. Lawlor
8. Sophia Mah
9. Michelle Scurr
10. Sara E. Howden
11. Kanta Subbarao
12. Melissa H. Little

Reviewed by ScreenIT

Plant-based production of SARS-CoV-2 antigens for use in a subunit vaccine

1. Jordan Demone
2. Maryam Nourimand
3. Mariam Maltseva
4. Mina Nasr-Sharif
5. Yannick Galipeau
6. Marc-André Langlois
7. Allyson M. MacLean

Reviewed by ScreenIT

Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

1. Naser Nasrollahzadeh
2. Peyman Karami
3. Jian Wang
4. Lida Bagheri
5. Yanheng Guo
6. Philippe Abdel-Sayed
7. Lee Laurent-Applegate
8. Dominique P Pioletti

• Curated by eLife

  Evaluation Summary:

  This is the study to determine the effects of mechanical loading on temperature changes in the joint and how the mechano-thermal transduction may influence chondrocyte behavior. This manuscript will be of interest to the clinicians and researchers who are working on tissue engineering and cartilage regeneration. The study has high clinical relevance. It provides new evidence that the mechanical stimuli plus with the temperature increase could influence the cell chondrogenic response. The data support the conclusions of the manuscript within the current context, although several issues need to be addressed.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

SARS-CoV-2 causes human BBB injury and neuroinflammation indirectly in a linked organ chip platform

1. Peng Wang
2. Lin Jin
3. Min Zhang
4. Yunsong Wu
5. Zilei Duan
6. Wenwen Chen
7. Chaoming Wang
8. Zhiyi Liao
9. Jianbao Han
10. Yingqi Guo
11. Yaqiong Guo
12. Yaqing Wang
13. Ren Lai
14. Jianhua Qin

Reviewed by ScreenIT

Virtual mouse brain histology from multi-contrast MRI via deep learning

1. Zifei Liang
2. Choong H Lee
3. Tanzil M Arefin
4. Zijun Dong
5. Piotr Walczak
6. Song-Hai Shi
7. Florian Knoll
8. Yulin Ge
9. Leslie Ying
10. Jiangyang Zhang

• Curated by eLife

  Evaluation Summary:

  This paper demonstrates how MRI can be used to mimic histological measures. This is something that the field of MRI has dubbed virtual histology (or MR-histology) for a while, but to my knowledge this paper is the first convincing demonstration that it can be achieved. The paper combines open access mouse histology data from the Allen Institute with their own multimodal post-mortem MRI, and using deep convolutional networks, are able to build models that map MRI data onto multiple histological contrasts. Some of the results are impressive, such as predicting the outcome of histology on mutant shiverer mice.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Nanobody-Functionalized Cellulose for Capturing SARS-CoV-2

1. Xin Sun
2. Shaobo Yang
3. Amal A. Al-Dossary
4. Shana Broitman
5. Yun Ni
6. Ming Guan
7. Mengdi Yang
8. Jiahe Li

Reviewed by ScreenIT

Antiviral Face Mask Functionalized with Solidified Hand Soap: Low-Cost Infection Prevention Clothing against Enveloped Viruses Such as SARS-CoV-2

1. Alba Cano-Vicent
2. Alberto Tuñón-Molina
3. Miguel Martí
4. Yukiko Muramoto
5. Takeshi Noda
6. Kazuo Takayama
7. Ángel Serrano-Aroca

Reviewed by ScreenIT

Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria

1. Kazuo Takayama
2. Alberto Tuñón-Molina
3. Alba Cano-Vicent
4. Yukiko Muramoto
5. Takeshi Noda
6. José Luis Aparicio-Collado
7. Roser Sabater i Serra
8. Miguel Martí
9. Ángel Serrano-Aroca

Reviewed by ScreenIT

Environmental fluctuations reshape an unexpected diversity-disturbance relationship in a microbial community

1. Christopher P Mancuso
2. Hyunseok Lee
3. Clare I Abreu
4. Jeff Gore
5. Ahmad S Khalil

• Curated by eLife

  Evaluation Summary:

  How species diversity responds to external perturbations (such as resource influxes and dilutions) is an important ecological question. Using soil microbial communities in devices where perturbations can be introduced in various forms and mathematical modelling, this study nicely illustrates how diversity is influenced by perturbations.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife