Biochemistry

  1. More than just a ticket canceller: The mitochondrial processing peptidase matures complex precursor proteins at internal cleavage sites

    1. Jana Friedl
    2. Michael R. Knopp
    3. Carina Groh
    4. Eyal Paz
    5. Sven B. Gould
    6. Felix Boos
    7. Johannes M. Herrmann

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. The crystal structure of the Ca 2+ -ATPase 1 from Listeria monocytogenes reveals a pump primed for dephosphorylation

    1. Sara Basse Hansen
    2. Mateusz Dyla
    3. Caroline Neumann
    4. Esben Meldgaard Hoegh Quistgaard
    5. Jacob Lauwring Andersen
    6. Magnus Kjaergaard
    7. Poul Nissen

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair

    1. Maria Silva-Garcia
    2. Oguz Bolgi
    3. Breyan Ross
    4. Esther Pilla
    5. Vijayalakshmi Kari
    6. Markus Killisch
    7. Nadine Stark
    8. Christof Lenz
    9. Melanie Spitzner
    10. Mark D. Gorrell
    11. Marian Grade
    12. Henning Urlaub
    13. Matthias Dobbelstein
    14. Robert Huber
    15. Ruth Geiss-Friedlander

    Reviewed by eLife

    1 evaluationAppears in 1 listLatest version Latest activity

  4. The half-life of the bone-derived hormone osteocalcin is regulated through O -glycosylation in mice, but not in humans

    1. Omar Al Rifai
    2. Catherine Julien
    3. Denis Faubert
    4. Erandi Lira-Navarrete
    5. Yoshiki Narimatsu
    6. Julie Lacombe
    7. Henrik Clausen
    8. Mathieu Ferron

    Reviewed by eLife

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Optogenetic activation of heterotrimeric Gi proteins by LOV2GIVe— a rationally engineered modular protein

    1. Mikel Garcia-Marcos
    2. Kshitij Parag-Sharma
    3. Arthur Marivin
    4. Marcin Maziarz
    5. Alex Luebbers
    6. Lien T. Nguyen

    Reviewed by eLife

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide

    1. Santamaria Salvatore
    2. Doretta Cuffaro
    3. Elisa Nuti
    4. Lidia Ciccone
    5. Tiziano Tuccinardi
    6. Francesca Liva
    7. Felicia D’Andrea
    8. Rens de Groot
    9. Armando Rossello
    10. Josefin Ahnström

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  7. TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states

    1. Simiao Xu
    2. Yangyang Liu
    3. Ruixiang Hu
    4. Min Wang
    5. Oliver Stöhr
    6. Yibo Xiong
    7. Liang Chen
    8. Hong Kang
    9. Lingyun Zheng
    10. Songjie Cai
    11. Li He
    12. Cunchuan Wang
    13. Kyle D Copps
    14. Morris F White
    15. Ji Miao

    Reviewed by eLife

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats

    1. Sara Sajko
    2. Irina Grishkovskaya
    3. Julius Kostan
    4. Melissa Graewert
    5. Kim Setiawan
    6. Linda Trübestein
    7. Korbinian Niedermüller
    8. Charlotte Gehin
    9. Antonio Sponga
    10. Martin Puchinger
    11. Anne-Claude Gavin
    12. Thomas A. Leonard
    13. Dimitri I. Svergun
    14. Terry K. Smith
    15. Brooke Morriswood
    16. Kristina Djinovic-Carugo

    Reviewed by Review Commons

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. A giant leap in sequence space reveals the intracellular complexities of evolving a new function

    1. Kelsi R. Hall
    2. Katherine J. Robins
    3. Michelle H. Rich
    4. Mark J. Calcott
    5. Janine N. Copp
    6. Elsie M. Williams
    7. Rory F. Little
    8. Ralf Schwörer
    9. Gary B. Evans
    10. Wayne M. Patrick
    11. David F. Ackerley

    Reviewed by eLife

    1 evaluationAppears in 1 listLatest version Latest activity

  10. The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

    1. Maire Gavagan
    2. Noel Jameson
    3. Jesse G Zalatan

    • Curated by eLife

      eLife assessment

      This study presents a valuable and elegant kinetic analysis of the GSKbeta activity as a function of phosphorylation and Axin binding - providing insights into critical steps of Wnt pathway signaling. The results will be of big use to the broader signaling community, however, the incomplete dissection of the mechanism by which Axin binding inhibits GSKbeta inhibitory phosphorylation remains a weakness of this study. The work will be of broad interest to cell biologists and biochemists.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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