Biochemistry

Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein

1. Mikel Garcia-Marcos
2. Kshitij Parag-Sharma
3. Arthur Marivin
4. Marcin Maziarz
5. Alex Luebbers
6. Lien T Nguyen

Reviewed by eLife

Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide

1. Santamaria Salvatore
2. Doretta Cuffaro
3. Elisa Nuti
4. Lidia Ciccone
5. Tiziano Tuccinardi
6. Francesca Liva
7. Felicia D’Andrea
8. Rens de Groot
9. Armando Rossello
10. Josefin Ahnström

Reviewed by eLife

TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states

1. Simiao Xu
2. Yangyang Liu
3. Ruixiang Hu
4. Min Wang
5. Oliver Stöhr
6. Yibo Xiong
7. Liang Chen
8. Hong Kang
9. Lingyun Zheng
10. Songjie Cai
11. Li He
12. Cunchuan Wang
13. Kyle D Copps
14. Morris F White
15. Ji Miao

Reviewed by eLife

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats

1. Sara Sajko
2. Irina Grishkovskaya
3. Julius Kostan
4. Melissa Graewert
5. Kim Setiawan
6. Linda Trübestein
7. Korbinian Niedermüller
8. Charlotte Gehin
9. Antonio Sponga
10. Martin Puchinger
11. Anne-Claude Gavin
12. Thomas A. Leonard
13. Dimitri I. Svergun
14. Terry K. Smith
15. Brooke Morriswood
16. Kristina Djinovic-Carugo

Reviewed by Review Commons

A giant leap in sequence space reveals the intracellular complexities of evolving a new function

1. Kelsi R. Hall
2. Katherine J. Robins
3. Michelle H. Rich
4. Mark J. Calcott
5. Janine N. Copp
6. Elsie M. Williams
7. Rory F. Little
8. Ralf Schwörer
9. Gary B. Evans
10. Wayne M. Patrick
11. David F. Ackerley

Reviewed by eLife

The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

1. Maire Gavagan
2. Noel Jameson
3. Jesse G Zalatan

• Curated by eLife

  eLife assessment

  This study presents a valuable and elegant kinetic analysis of the GSKbeta activity as a function of phosphorylation and Axin binding - providing insights into critical steps of Wnt pathway signaling. The results will be of big use to the broader signaling community, however, the incomplete dissection of the mechanism by which Axin binding inhibits GSKbeta inhibitory phosphorylation remains a weakness of this study. The work will be of broad interest to cell biologists and biochemists.

Reviewed by eLife

The conserved protein CBA1 is required for vitamin B ₁₂ uptake in different algal lineages

1. Andrew P. Sayer
2. Marcel Llavero-Pasquina
3. Katrin Geisler
4. Andre Holzer
5. Freddy Bunbury
6. Gonzalo I. Mendoza-Ochoa
7. Andrew D. Lawrence
8. Martin J. Warren
9. Payam Mehrshahi
10. Alison G. Smith

Reviewed by PREreview

Phosphorylation controls spatial and temporal activities of motor‐PRC1 complexes to complete mitosis

1. Agata Gluszek‐Kustusz
2. Benjamin Craske
3. Thibault Legal
4. Toni McHugh
5. Julie PI Welburn

Reviewed by preLights

cGLRs are a diverse family of pattern recognition receptors in innate immunity

1. Yao Li
2. Kailey M. Slavik
3. Hunter C. Toyoda
4. Benjamin R. Morehouse
5. Carina C. de Oliveira Mann
6. Anamaria Elek
7. Shani Levy
8. Zhenwei Wang
9. Kepler S. Mears
10. Jingjing Liu
11. Dmitry Kashin
12. Ximing Guo
13. Tali Mass
14. Arnau Sebé-Pedrós
15. Frank Schwede
16. Philip J. Kranzusch

Reviewed by PREreview

Comparison of urine proteomes from tumor-bearing mice with those from tumor-resected mice

1. Heng Ziqi
2. Zhao Chenyang
3. Gao Youhe

Reviewed by PREreview