1. SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion

    This article has 9 authors:
    1. Dhiraj Mannar
    2. James W. Saville
    3. Xing Zhu
    4. Shanti S. Srivastava
    5. Alison M. Berezuk
    6. Katharine S. Tuttle
    7. Citlali Marquez
    8. Inna Sekirov
    9. Sriram Subramaniam

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro : insights into structural requirements for binding

    This article has 16 authors:
    1. Sabrina Bertini
    2. Anna Alekseeva
    3. Stefano Elli
    4. Isabel Pagani
    5. Serena Zanzoni
    6. Giorgio Eisele
    7. Ravi Krishnan
    8. Klaus P Maag
    9. Christian Reiter
    10. Dominik Lenhart
    11. Rudolf Gruber
    12. Edwin A Yates
    13. Elisa Vicenzi
    14. Annamaria Naggi
    15. Antonella Bisio
    16. Marco Guerrini

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

    This article has 19 authors:
    1. Dhiraj Mannar
    2. James W. Saville
    3. Zehua Sun
    4. Xing Zhu
    5. Michelle M. Marti
    6. Shanti S. Srivastava
    7. Alison M. Berezuk
    8. Steven Zhou
    9. Katharine S. Tuttle
    10. Michele D. Sobolewski
    11. Andrew Kim
    12. Benjamin R. Treat
    13. Priscila Mayrelle Da Silva Castanha
    14. Jana L. Jacobs
    15. Simon M. Barratt-Boyes
    16. John W. Mellors
    17. Dimiter S. Dimitrov
    18. Wei Li
    19. Sriram Subramaniam

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  4. Amyloidogenesis of SARS-CoV-2 Spike Protein

    This article has 2 authors:
    1. Sofie Nyström
    2. Per Hammarström

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  5. Structural and functional insights of the human peroxisomal ABC transporter ALDP

    This article has 6 authors:
    1. Yutian Jia
    2. Yanming Zhang
    3. Wenhao Wang
    4. Jianlin Lei
    5. Zhengxin Ying
    6. Guanghui Yang
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This paper will be of interest to the lipid metabolism and transporter communities. Fatty acids that are too long to be transported into mitochondria are instead transported into peroxisomes for their break down i.e., beta-oxidation. The authors have determined the cryo-EM structure of human ABC transporter ABCD1 (ALDP), which translocates very-long-chain fatty acids (VLCFA) conjugated to coenzyme A across peroxisomal membranes, in complex with its substrate. While the work is well done, it is unclear what new mechanistic insights are gained from the ALDP structure. Also, the proposed conformational differences based on AlphaFold models should be taken with caution.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma

    This article has 5 authors:
    1. Pavan Vedula
    2. Hsin-Yao Tang
    3. David W. Speicher
    4. Anna Kashina
    5. The UPenn COVID Processing Unit

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Structure of the human ATM kinase and mechanism of Nbs1 binding

    This article has 2 authors:
    1. Christopher Warren
    2. Nikola P Pavletich
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation summary

      This manuscript is of broad interest to the DNA-repair and structural biology field. The paper describes new insights into the interaction between ATM and Nsb1, proteins central to repairing DNA double-strand breaks in humans. Overall, the structural cryo-electron microscopy data is solid and the data well analyzed and presented with key claims directly related to and supporting previous known findings.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  8. Systematic investigation of the link between enzyme catalysis and cold adaptation

    This article has 4 authors:
    1. Catherine Stark
    2. Teanna Bautista-Leung
    3. Joanna Siegfried
    4. Daniel Herschlag
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      Are enzymes found in organisms that optimally grow at colder temperatures are more active than the same enzymes found in organisms that optimally grow at warmer temperatures? Here, an assessment of the catalytic constants for approximately 2200 enzymes (obtained from the BRENDA database) showed no correlation between the relative catalytic activity and the optimum growth temperature. Further support for this conclusion was obtained from the measurement of the catalytic constant from a selection of ketosteroid isomerases from organisms that optimally grow between 15 and 46 degrees centigrade. These are interesting results, although the significance with respect to earlier studies has not been clearly explained.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. Regulation of ERK2 activity by dynamic S-acylation

    This article has 4 authors:
    1. Saara-Anne Azizi
    2. Tian Qiu
    3. Noah E. Brookes
    4. Bryan C. Dickinson
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This manuscript describes the regulation of ERK1/2, two protein kinases that play important roles in cell signaling, by protein cysteine palmitoylation. The intriguing observations reported here could be of broad interest to colleagues in the field of cell signaling and protein post-translational modifications. Mechanistic understanding is, however, still limited and the work would benefit from additional experimental evidence.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Deep Mutational Engineering of broadly-neutralizing and picomolar affinity nanobodies to accommodate SARS-CoV-1 & 2 antigenic polymorphism

    This article has 11 authors:
    1. Adrien Laroche
    2. Maria Lucia Orsini Delgado
    3. Philippe Cuniasse
    4. Steven Dubois
    5. Raphaël Sierocki
    6. Fabrice Gallais
    7. Stéphanie Debroas
    8. Laurent Bellanger
    9. Stéphanie Simon
    10. Bernard Maillère
    11. Hervé Nozach

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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