Biochemistry

Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation

1. Wilhelm Vaysse-Zinkhöfer
2. Enya Marie Catherine Alcindor
3. Nicholas Garaffo
4. David Paul Toczyski

• Curated by eLife

  eLife Assessment

  The study presents a valuable finding on the ubiquitin-dependent regulatory loop in which proapoptotic Bim is targeted to the E3 ubiquitin ligase Cul5-Wsb2-mediated degradation through its sequestration by BCL2 proteins. The conclusions are supported by incomplete evidence and would benefit from additional experiments addressing both the mechanistic understanding and the physiological/cancer-related significance of the study.

Reviewed by eLife

Rare variant in intracellular loop-2 of the ghrelin receptor reveals novel mechanisms of GPCR biased signaling and trafficking

1. Elsa M. Balfe
2. Alexandre Torbey
3. Lara Kohlenbach
4. Jade A. Sency
5. Asuka Inoue
6. Lawrence S. Barak
7. Joshua D. Gross

Reviewed by PREreview

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle

1. Dipsikha Biswas
2. Ever Espino-Gonzalez
3. Danial Ahwazi
4. Jordana B. Freemantle
5. Amy M. Ehrlich
6. Charline Jomard
7. Jonas Brorson
8. Agnete N. Schou
9. Jean Farup
10. Julien Gondin
11. Jesper Just
12. Marc Foretz
13. Jonas T. Treebak
14. Marianne Agerholm
15. Kei Sakamoto

Reviewed by PREreview

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline

1. William S. Stuart
2. Michail N. Isupov
3. Mathew McLaren
4. Christopher H. Jenkins
5. Adam Monier
6. Bertram Daum
7. Isobel H. Norville
8. Vicki A.M. Gold
9. Nicholas J. Harmer

Reviewed by preLights