1. Branched‐chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast

    This article has 6 authors:
    1. Heidi M Blank
    2. Carsten Reuse
    3. Kerstin Schmidt‐Hohagen
    4. Staci E Hammer
    5. Karsten Hiller
    6. Michael Polymenis

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function

    This article has 4 authors:
    1. Adedeji M Aderounmu
    2. P Joseph Aruscavage
    3. Bryan Kolaczkowski
    4. Brenda L Bass
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a valuable paper describing an attempt to reconstruct the evolution of Dicer. Using ancestral reconstruction approaches, the authors carefully examine the biochemical characteristics of reconstructed proteins at various junction points in the animal lineage. They provide solid evidence that the deepest ancestrally reconstructed protein has double-stranded RNA stimulated ATPase activity and that this characteristic was lost along the vertebrate lineage. This paper will be of interest to scientists in the RNA-protein interaction and protein evolution fields.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Aedes aegypti eggs use rewired polyamine and lipid metabolism to survive extreme desiccation

    This article has 4 authors:
    1. Anjana Prasad
    2. Sreesa Sreedharan
    3. Baskar Bakthavachalu
    4. Sunil Laxman

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  4. Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

    This article has 8 authors:
    1. Loïc Duffet
    2. Elyse T Williams
    3. Andrea Gresch
    4. Simin Chen
    5. Musadiq A Bhat
    6. Dietmar Benke
    7. Nina Hartrampf
    8. Tommaso Patriarchi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable Tools and Resources paper presents new tools for investigating GLP-1 signaling: a genetically-encoded sensor constructed from a mutated GLP1R receptor as well as a caged agonist peptide. The evidence for these tools working as advertised is solid and they may be helpful for screening compounds that bind to GLP1R.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

    This article has 15 authors:
    1. Amit Kumar
    2. Oscar Vadas
    3. Nicolas Dos Santos Pacheco
    4. Xu Zhang
    5. Kin Chao
    6. Nicolas Darvill
    7. Helena Ø Rasmussen
    8. Yingqi Xu
    9. Gloria Meng-Hsuan Lin
    10. Fisentzos A Stylianou
    11. Jan Skov Pedersen
    12. Sarah L Rouse
    13. Marc L Morgan
    14. Dominique Soldati-Favre
    15. Stephen Matthews
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors describe the first full-length crystal structure and solution conformation of the GAC protein from Toxoplasma gondii. The data are convincing and support a model in which GAC uses multiple conformations and lipid-binding surfaces. This paper presents an important contribution to our understanding of the molecular machinery involved in host cell invasion, but questions remain about how this protein links to the cytoskeleton and functions during the invasion process.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Cryo-EM structure of the endothelin-1-ETB-Gi complex

    This article has 4 authors:
    1. Fumiya K Sano
    2. Hiroaki Akasaka
    3. Wataru Shihoya
    4. Osamu Nureki
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Based on the Cryo-EM structure of human ETB in complex with the vasoconstricting peptide ET-1 and the inhibitory G-protein (Gi), this valuable study presents convincing data on how agonist binding is coupled to Gi-protein binding. The complex structure is solid and will appeal to the GPCR and pharmacology communities.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase

    This article has 6 authors:
    1. Valentin Mitterer
    2. Matthias Thoms
    3. Robert Buschauer
    4. Otto Berninghausen
    5. Ed Hurt
    6. Roland Beckmann
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study substantially advances our understanding of the process of ribosome maturation. The authors have purified and determined the structures of several nucleolar ribosome assembly intermediates in yeast using cryo-electron microscopy (cryo-EM). The study combines genetic, biochemical, and structural analysis to provide compelling support for the conclusions the authors wish to draw. The work will be of broad interest to cell biologists, biochemists, and structural biologists.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  8. Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens

    This article has 8 authors:
    1. Karel Bezstarosti
    2. Mart M. Lamers
    3. Wouter A. S. Doff
    4. Peter C. Wever
    5. Khoa T. D. Thai
    6. Jeroen J. A. van Kampen
    7. Bart L. Haagmans
    8. Jeroen A. A. Demmers

    Reviewed by PREreview, ScreenIT

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  9. Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15

    This article has 12 authors:
    1. Luba Mahbub
    2. Guennadi Kozlov
    3. Pengyu Zong
    4. Emma L Lee
    5. Sandra Tetteh
    6. Thushara Nethramangalath
    7. Caroline Knorn
    8. Jianning Jiang
    9. Ashkan Shahsavan
    10. Lixia Yue
    11. Loren Runnels
    12. Kalle Gehring
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this potentially important study, Mahbub and colleagues examine how the small GTPase ARL15 regulates ion transport. Using a complementary array of techniques, the authors gathered solid evidence for the binding of ARL15 to CNNM proteins, resulting in a proposal how this may affect the function of the TRPM7 channel. Additional experiments are required to fully substantiate the claims.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation

    This article has 7 authors:
    1. Hamida Laroussi
    2. Ariadna B Juarez‐Martinez
    3. Aline Le Roy
    4. Elisabetta Boeri Erba
    5. Frank Gabel
    6. Bernard de Massy
    7. Jan Kadlec

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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