1. Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

    This article has 5 authors:
    1. Benjamin R Duewell
    2. Naomi E Wilson
    3. Gabriela M Bailey
    4. Sarah E Peabody
    5. Scott D Hansen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript describes the synergy among PI3Kbeta activators, providing compelling results concerning the mechanism of their activation. The particular strengths of the work arise to a great extend from the reconstitution system better mimicking the natural environment of the plasma membrane than previous setups have. The study will be a landmark contribution to the signaling field.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  2. Novel sterol binding domains in bacteria

    This article has 7 authors:
    1. Liting Zhai
    2. Amber C Bonds
    3. Clyde A Smith
    4. Hannah Oo
    5. Jonathan Chiu-Chun Chou
    6. Paula V Welander
    7. Laura MK Dassama
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a valuable contribution to our understanding of how some bacteria can transport sterols from the cytoplasm to the outer membrane. Though much remains to be tested and explored, the data and analyses presented here provide solid evidence for the genetic and physical interaction of BstA/B/C with bacterially-produced sterols. The manuscript will be of interest to scientists focusing on the characterization of novel bacterial proteins and those studying lipid transport and acquisition in bacterial pathogens.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  3. Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe

    This article has 18 authors:
    1. Fouad Ouasti
    2. Maxime Audin
    3. Karine Fréon
    4. Jean-Pierre Quivy
    5. Mehdi Tachekort
    6. Elizabeth Cesard
    7. Aurélien Thureau
    8. Virginie Ropars
    9. Paloma Fernández Varela
    10. Gwenaelle Moal
    11. Ibrahim Soumana Adamou
    12. Aleksandra Uryga
    13. Pierre Legrand
    14. Jessica Andreani
    15. Raphaël Guerois
    16. Geneviève Almouzni
    17. Sarah Lambert
    18. Francoise Ochsenbein
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study advances our understanding of the machinery that couples DNA synthesis with the deposition of histone proteins onto newly synthesized DNA. A convincing array of experiments combines NMR, protein biochemistry, and in vivo analyses of Chromatin Assembly Factor-1 of fission yeast. The work is of interest to researchers in the field of chromosome/chromatin biology as well as epigenetics.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  4. Acyl-CoA thioesterase-2 facilitates β-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner

    This article has 13 authors:
    1. Carmen Bekeova
    2. Ji In Han
    3. Heli Xu
    4. Evan Kerr
    5. Brittney Blackburne
    6. Shannon C. Lynch
    7. Clementina Mesaros
    8. Marta Murgia
    9. Rajanikanth Vadigepalli
    10. Joris Beld
    11. Roberta Leonardi
    12. Nathaniel W. Snyder
    13. Erin L. Seifert
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents new data highlighting the importance of appropriate coenzyme A handling in the mitochondria for maintaining appropriate energy production capacity. Several findings regarding the role of a key metabolic enzyme in how skeletal muscle cells use different substrates for energy production are valuable and supported by solid evidence, but there are concerns whether the data support the conclusion that ACOT2 regulates mitochondrial matrix acyl-CoA levels in white skeletal muscle to facilitate fatty acid oxidation β-oxidation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions

    This article has 6 authors:
    1. Jixing Lyu
    2. Tianqi Zhang
    3. Michael T Marty
    4. David Clemmer
    5. David H Russell
    6. Arthur Laganowsky
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important biophysical study combining native mass spectrometry with mutant cycles to estimate the thermodynamic components of lipid A binding to the ABC transporter MsbA. Solid evidence supports the binding energies for lipid-protein interactions to MsbA using this approach, which could be later applied to other membrane proteins in general.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 2 listsLatest version Latest activity
  6. The role of RNA in the maintenance of chromatin domains as revealed by antibody-mediated proximity labelling coupled to mass spectrometry

    This article has 8 authors:
    1. Rupam Choudhury
    2. Anuroop Venkateswaran Venkatasubramani
    3. Jie Hua
    4. Marco Borsò
    5. Celeste Franconi
    6. Sarah Kinkley
    7. Ignasi Forné
    8. Axel Imhof

    Reviewed by Review Commons

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

    This article has 8 authors:
    1. Jake W Anderson
    2. David Vaisar
    3. David N Jones
    4. Laurel M Pegram
    5. Guy P Vigers
    6. Huifen Chen
    7. John G Moffat
    8. Natalie G Ahn
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study provides compelling evidence to explain how chemical variations within a set of kinase inhibitors drive the selection of specific Erk2 conformations. Conformational selection plays a critical role in targeting medically relevant kinases such as Erk2 and the findings reported here open new avenues for designing small molecule inhibitors that block the active site while also steering the population of the enzyme into active or inactive conformations. Since protein dynamics and conformational ensembles are essential for enzyme function, this work will be of broad interest to those working in drug development, signal transduction, and enzymology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity

    This article has 16 authors:
    1. Edward M Germany
    2. Nakajohn Thewasano
    3. Kenichiro Imai
    4. Yuki Maruno
    5. Rebecca S Bamert
    6. Christopher J Stubenrauch
    7. Rhys A Dunstan
    8. Yue Ding
    9. Yukari Nakajima
    10. XiangFeng Lai
    11. Chaille T Webb
    12. Kentaro Hidaka
    13. Kher Shing Tan
    14. Hsinhui Shen
    15. Trevor Lithgow
    16. Takuya Shiota
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reports the identification of a new amino acid sequence motif (i.e., "internal beta-signal") on outer membrane proteins, which is recognized by beta-assembly machinery in gram-negative bacteria. The authors carried out rigorous experiments, providing compelling evidence in support of their conclusions. This work significantly advances our understanding of the biogenesis of outer membrane proteins.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  9. A bioactive peptide from the pearl has dual roles in resisting SARS-CoV-2 infection and its complications

    This article has 9 authors:
    1. Xiaojun Liu
    2. Yayu Wang
    3. Zehui Yin
    4. Qin Wang
    5. Xinjiani Chen
    6. Bailei Li
    7. Liping Yao
    8. Zhen Zhang
    9. Rongqing Zhang

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Structural assembly of the bacterial essential interactome

    This article has 2 authors:
    1. Jordi Gómez Borrego
    2. Marc Torrent Burgas

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
Previous Page 22 of 90 Next