Association Between Cardiovascular Disease and 2Complete Edentulism in a Nationally Representative U.S. Adults

  1. Saud Alyahya
  2. Basel Hamoud
  3. Ali Alqattan
  4. Masoud Almadoud
  5. Yousef Almehjan
  6. Rashed Alajmi
  7. Hesham Alhazmi
  8. Hend Alqaderi

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Abstract

(1) Background: Cardiovascular disease (CVD) and edentulism are major public health challenges with shared risk factors and overlapping inflammatory pathways. (2) Methods: This study investigates the association between complete tooth loss and cardiovascular disease in a nationally representative sample of U.S. adults using data from the 2015–2018 National Health and Nutrition Examination Survey (NHANES). A cross-sectional analysis was conducted among adults aged ≥30 years, incorporating clinically assessed dental status and self-reported CVD outcomes. Weighted multivariate logistic regression models were conducted to investigate the relationship between complete edentulism and different cardiovascular conditions adjusted for age, sex, race/ethnicity, education, income, BMI, and diabetes status. 3) Results: Individuals with cardiovascular conditions, including coronary heart disease, heart attack, stroke, and congestive heart failure, had higher odds of complete edentulism compared to those without cardiovascular conditions, with odds ratios ranging from 1.60 to 1.85 (p < 0.01). Older age, lower educational attainment, and lower income were also associated with higher odds of tooth loss. (4) Conclusions: This study contributes further to the existing evidence of oral-systemic health link, showing that individuals with cardiovascular conditions are more likely to be edentulous.

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  1. PREreview

    This Zenodo record is a permanently preserved version of a Structured PREreview. You can view the complete PREreview at https://prereview.org/reviews/17117636.

    Does the introduction explain the objective of the research presented in the preprint? Yes The authors wrote a comprehensive introduction on CVD and edentulism based on previous studies. They highlighted the gaps in the literature and properly justified the study in filling in the gaps. However, we are of the view that edentulism should have been clearly defined for the readers to easily comprehend.
    Are the methods well-suited for this research? Somewhat appropriate The study design was appropriate for the analysis. They used appropriate statistical tools and methods for the analysis; however, we identified minor errors that we recommend they address. 2.4 The Potential Confounding Variable Under this section, the sentence "...was classified as a binary variable (male or female)" is incomplete. It should properly start with "Sex." Also under race, the authors should describe what "other race" means or stands for. Otherwise, they should be listed in the appendix.
    Are the conclusions supported by the data? Highly supported The conclusions of the paper are sound and comprehensive. They made recommendations to relevant stakeholders, such as clinicians and policymakers, to adopt enhanced dental care services and also for them to collaborate with funding agencies to support dental and CVD care.
    Are the data presentations, including visualizations, well-suited to represent the data? Highly appropriate and clear For the kind of data and analysis strategy they adopted, the representation of their result, which they used tables was appropriate.
    How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research? Very clearly The authors clearly discussed their results and compared their results with previous studies, either supporting or contrasting findings in line with their results. They recommended a longitudinal study to properly understand the causal relationship between CVD risk and edentulism.
    Is the preprint likely to advance academic knowledge? Highly likely Yes, the study has expanded our understanding of the relationship between CVD and edentulism.
    Would it benefit from language editing? Yes Minor grammatical errors and subject-verb agreements were detected. Addressing these could enhance the readability of the paper.
    Would you recommend this preprint to others? Yes, it's of high quality Yes, the paper is of high quality. It sheds light on the relationship between CVD and edentulism. It made relevant recommendations to stakeholders to help enhance dental care services.
    Is it ready for attention from an editor, publisher or broader audience? Yes, after minor changes We recommend that the title of the paper be refined a bit. Suggested title: "The Association between Cardiovascular Disease and Complete Edentulism in a Population of Nationally Represented Adults in the United States of America: A Retrospective Study." We recommend that some minor grammatical errors be addressed. In the introduction, the authors should clearly define edentulism.

    Competing interests

    The authors declare that they have no competing interests.

  2. Version published to 10.20944/preprints202507.0145.v1