Evaluated articles

Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction

1. Yoshiko M Ikushima
2. Kuan-Chan Chen
3. Richard J. Sulston
4. Domenico Mattiucci
5. Eleanor J. Brain
6. Stefanie A Fung Xin Zi
7. Karla J. Suchacki
8. Benjamin J. Thomas
9. Andrea Lovdel
10. Matthew Bennett
11. Hiroshi Kobayashi
12. Phillip D. Whitfield
13. Keiyo Takubo
14. Andrew H. Baker
15. Nicholas M. Morton
16. Robert K. Semple
17. William P. Cawthorn

Reviewed by PREreview

The ROS-producing enzyme NADPH oxidase/RBOH is a Ca2+ channel regulated by protons in the eukaryotic kingdom

1. Liangyu Liu
2. Zijian Yang
3. Yangbo Chen
4. Chunhui Song
5. Changxin Feng
6. Changyuan Li
7. Shuo Liu
8. Enjie Yu
9. Hao Tian
10. Zebin Liu
11. Zhangli Ye
12. Wei Guo
13. Lei Gao
14. Yujia Sun
15. Dongdong Kong
16. Congcong Hou
17. Legong Li

Reviewed by PREreview

Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women

1. Neil Carleton
2. Sanghoon Lee
3. Ruxuan Li
4. Jian Zou
5. Daniel D Brown
6. Jagmohan Hooda
7. Alexander Chang
8. Rahul Kumar
9. Linda R Klei
10. Lora H Rigatti
11. Joseph Newsome
12. Dixcy Jaba Sheeba John Mary
13. Jennifer M Atkinson
14. Raymond E West
15. Thomas D Nolin
16. Patrick J Oberly
17. Ziyu Huang
18. Donald Poirier
19. Emilia J Diego
20. Peter C Lucas
21. George Tseng
22. Michael T Lotze
23. Priscilla F McAuliffe
24. Ioannis K Zervantonakis
25. Steffi Oesterreich
26. Adrian V Lee

Reviewed by PREreview

A Novel Bispecific Antibody CVL006 Superior to AK112 for Dual Targeting of PD-L1 and VEGF in Cancer Therapy

1. Chunyan Wang
2. Hao Huang
3. Zeng Song
4. Zhongyuan Li
5. Jinwen Huang
6. Liang Cao
7. Ziai Wu
8. Junfang Pan
9. Xiaokun Shen

Reviewed by PREreview

Article Processing Charges Threaten Global Health Equity: Open Access is Closed Science

1. Gabriella Y. Hyman
2. Taylor Wurdeman
3. Nikathan Kumar
4. Isaac G. Alty
5. Callum Forbes
6. Robert Riviello
7. Nakul P. Raykar

Reviewed by PREreview

Acquisition of an immunosuppressive microenvironment after CAR-T therapy drives T-cell dysfunction and resistance

1. Marianna Ponzo
2. Lorenzo Drufuca
3. Chiara Buracchi
4. Marco M. Sindoni
5. Silvia Nucera
6. Cristina Bugarin
7. Ramona Bason
8. Grazisa Rossetti
9. Raoul Bonnal
10. Cristian Meli
11. Benedetta Rambaldi
12. Federico Lussana
13. Silvia Ferrari
14. Alex Moretti
15. Giulia Risca
16. Christian Pellegrino
17. Markus G. Manz
18. Stefania Galimberti
19. Alessandro Rambaldi
20. Giuseppe Gaipa
21. Andrea Biondi
22. Massimiliano Pagani
23. Chiara F. Magnani

Reviewed by PREreview

Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice

1. Kai Xu
2. Irene Covila-Corona
3. María Dolores Frutos
4. María Ángeles Núñez-Sánchez
5. Dhruvi Makhanasa
6. Pratham Viral Shah
7. Grace Guzman
8. Bruno Ramos-Molina
9. Medha Priyadarshini
10. Md. Wasim Khan

Reviewed by PREreview, Arcadia Science

Reframing death to live diversity: Positive death valence reduces implicit homonegativity

1. Mel Stiller

Reviewed by PREreview

Nuclear body reorganization by the viral RNA kaposin promotes Kaposi’s sarcoma-associated herpesvirus gene expression

1. Mariel Kleer
2. Michael J. Johnston
3. Jennifer A. Corcoran

Reviewed by PREreview

InterPLM: Discovering Interpretable Features in Protein Language Models via Sparse Autoencoders

1. Elana Simon
2. James Zou

Reviewed by PREreview

Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimer’s Disease-linked pathologies in cultured human neurons

1. Amanda M. Snead
2. Sruchi Patel
3. Mia Krout
4. Ryan S. Hippman
5. Gabrielle Smith
6. Diya Dileep
7. Nitya Chagoor
8. Rachel Shi
9. Ricardo Linares
10. Andrew Dobria
11. Stephanie M. Cologna
12. Camerron Crowder
13. Leslie N. Aldrich
14. Swetha Gowrishankar

Reviewed by PREreview

Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

1. Veronica H Ryan
2. Sydney Lawton
3. Joel F Reyes
4. James Hawrot
5. Ashley M Frankenfield
6. Sahba Seddighi
7. Daniel M Ramos
8. Faraz Faghri
9. Nicholas L Johnson
10. Jizhong Zou
11. Martin Kampmann
12. John Replogle
13. Hebao Yuan
14. Kory R Johnson
15. Dragan Maric
16. Ling Hao
17. Mike A Nalls
18. Michael E Ward

• Curated by eLife

  eLife Assessment

  In this important manuscript, Ryan et al perform a genome-wide CRISPR based screen to identify genes that modulate TDP-43 levels in neurons. They identify a number of genes and pathways and highlight the BORC complex, which is required for anterograde lysosome transport as one such regulator of TDP-43 protein levels. Overall, this is a convincing study, which opens the door for additional future investigations on the regulation of TDP-43.

Reviewed by PREreview, eLife

In-depth Analysis of Artificial Intelligence for Climate Change Mitigation

1. Liyu Lu

Reviewed by PREreview

Transforming Healthcare in Africa: The Role of Artificial Intelligence in Combatting Infectious Diseases, Neglected Tropical Diseases, and Antimicrobial Resistance

1. ANGYIBA ANDIGEMA
2. NGNOTOUOM NGNOKAM Tania Cyrielle
3. NDJIE Daniel Laetitia
4. EWANE Ekwelle

Reviewed by PREreview

AI for United Nations Sustainable Development Goals

1. Mirza Abdul Aleem Baig
2. Jingchen Huang
3. Jingzehua Xu

Reviewed by PREreview

Theory of Differences Between Elements: Explanation of the Differences Between Quantum Physics and the Theory of General Relativity

1. Carlos Eduardo Ramos Cardoso

Reviewed by PREreview

Obligatory Necessity Theory: Elements and Facts Influenced by the Intensity of the Specific Physical Concept

1. Carlos Eduardo Ramos Cardoso

Reviewed by PREreview

Bricks or people? Investing more and better in Science, a dilemma for South American countries

1. Jose m. Paruelo
2. Miguel Sierra
3. Daniel Prieto

Reviewed by PREreview

The Transformative Economic impact of Artificial Intelligence

1. Syed Adnan Jawaid
2. Syed Ahmed

Reviewed by PREreview