The structure of an ancient genotype–phenotype map shaped the functional evolution of a protein family
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irst, we applied514different thresholds to classify genotypes as functional or nonfunctional, included promiscuous515genotypes when characterizing global production distributions, and characterized these516distributions using only genotypes with experimentally measured phenotypes.
So glad to see this! Nearly commented about some of these assumptions above. I particularly appreciate the comparison between "active" and "functional" variants in Extended Data Figure 6.
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