Evaluated articles

Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB

1. Joseph D. DeAngelo
2. Maxim I. Maron
3. Jacob S. Roth
4. Aliza M. Silverstein
5. Varun Gupta
6. Stephanie Stransky
7. Joel Basken
8. Joey Azofeifa
9. Simone Sidoli
10. Matthew J. Gamble
11. David Shechter

Reviewed by Arcadia Science

Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain

1. Chi Zhang
2. Qian Huang
3. Neil C Ford
4. Nathachit Limjunyawong
5. Qing Lin
6. Fei Yang
7. Xiang Cui
8. Ankit Uniyal
9. Jing Liu
10. Megha Mahabole
11. Hua He
12. Xuewei Wang
13. Irina Duff
14. Yiru Wang
15. Jieru Wan
16. Guangwu Zhu
17. Srinivasa N Raja
18. Hongpeng Jia
19. Dazhi Yang
20. Xinzhong Dong
21. Xu Cao
22. Scheffer C Tseng
23. Shaoqiu He
24. Yun Guan

• Curated by eLife

  eLife Assessment

  The authors provide convincing data that identify a novel, non-opioid biologic from human birth tissue products with anti-nociceptive properties in a preclinical mouse model of surgical pain. This important study highlights the potential use of naturally derived biologics from human birth tissues as safe and sustainable pain treatment options that do not possess the adverse side effects associated with opioids and synthetic pharmaceuticals. Whether these results will translate to the clinic remains to be seen, nevertheless, these preclinical findings are promising.

Reviewed by eLife, Arcadia Science

Human rod photoreceptor outer segments are supported by accessory inner segment structures

1. Tylor R. Lewis
2. Natalia V. Klementieva
3. Sebastien Phan
4. Carson M. Castillo
5. Keun-Young Kim
6. Lauren Y. Cao
7. Mark H. Ellisman
8. Vadim Y. Arshavsky
9. Oleg Alekseev

Reviewed by Arcadia Science

The membrane domains of mammalian adenylyl cyclases are lipid receptors

1. Marius Landau
2. Sherif Elsabbagh
3. Harald Gross
4. Adrian CD Fuchs
5. Anita CF Schultz
6. Joachim E Schultz

• Curated by eLife

  eLife Assessment

  This manuscript describes an important study of a new lipid-mediated regulation mechanism of adenylyl cyclases. The biochemical evidence provided is convincing and will trigger more research in this mechanism. This manuscript will be of interest to all scientists working on lipid regulation and adenylyl cyclases.

Reviewed by eLife, Arcadia Science

Peptipedia v2.0: A peptide sequence database and user-friendly web platform. A major update

1. Gabriel Cabas-Mora
2. Anamaría Daza
3. Nicole Soto-García
4. Valentina Garrido
5. Diego Alvarez
6. Marcelo Navarrete
7. Lindybeth Sarmiento-Varón
8. Julieta H. Sepúlveda Yañez
9. Mehdi D. Davari
10. Frederic Cadet
11. Álvaro Olivera-Nappa
12. Roberto Uribe-Paredes
13. David Medina-Ortiz

Reviewed by Arcadia Science

Raspberry Pi–powered imaging for plant phenotyping

1. Jose C. Tovar
2. J. Steen Hoyer
3. Andy Lin
4. Allison Tielking
5. Steven T. Callen
6. S. Elizabeth Castillo
7. Michael Miller
8. Monica Tessman
9. Noah Fahlgren
10. James C. Carrington
11. Dmitri A. Nusinow
12. Malia A. Gehan

Reviewed by Arcadia Science

Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred C. elegans mutation accumulation lines

1. Timothy A. Crombie
2. Moein Rajaei
3. Ayush S. Saxena
4. Lindsay M. Johnson
5. Sayran Saber
6. Robyn E. Tanny
7. José Miguel Ponciano
8. Erik C. Andersen
9. Juannan Zhou
10. Charles F. Baer

Reviewed by Arcadia Science

Ciliary biology intersects autism and congenital heart disease

1. Nia Teerikorpi
2. Micaela C. Lasser
3. Sheng Wang
4. Elina Kostyanovskaya
5. Ethel Bader
6. Nawei Sun
7. Jeanselle Dea
8. Tomasz J. Nowakowski
9. A. Jeremy Willsey
10. Helen Rankin Willsey

Reviewed by Arcadia Science

The rich evolutionary history of the ROS metabolic arsenal shapes its mechanistic plasticity at the onset of metazoan regeneration

1. Aurore Vullien
2. Aldine Amiel
3. Loeiza Baduel
4. Dilara Diken
5. Cécile Renaud
6. Michel Vervoort
7. Eric Röttinger
8. Eve Gazave

Reviewed by Arcadia Science

Development of a highly active engineered PETase enzyme for polyester degradation

1. Shapla Bhattacharya
2. Rossella Castagna
3. Hajar Estiri
4. Toms Upmanis
5. Andrea Ricci
6. Alfonso Gautieri
7. Emilio Parisini

Reviewed by Arcadia Science

Rapid protein evolution by few-shot learning with a protein language model

1. Kaiyi Jiang
2. Zhaoqing Yan
3. Matteo Di Bernardo
4. Samantha R. Sgrizzi
5. Lukas Villiger
6. Alisan Kayabolen
7. Byungji Kim
8. Josephine K. Carscadden
9. Masahiro Hiraizumi
10. Hiroshi Nishimasu
11. Jonathan S. Gootenberg
12. Omar O. Abudayyeh

Reviewed by Arcadia Science

Programming aliphatic polyester degradation by engineered bacterial spores

1. Ziyu Cui
2. Masamu Kawada
3. Yue Hui
4. Seunghyun Sim

Reviewed by Arcadia Science

Competition and cooperation: The plasticity of bacteria interactions across environments

1. Josephine Solowiej-Wedderburn
2. Jennifer T. Pentz
3. Ludvig Lizana
4. Björn Schröder
5. Peter Lind
6. Eric Libby

Reviewed by Arcadia Science

Cell type-specific immune regulation under symbiosis in a facultatively symbiotic coral

1. Maria Valadez-Ingersoll
2. Hanny E. Rivera
3. JK Da-Anoy
4. Matthew R. Kanke
5. Kelly Gomez-Campo
6. M. Isabel Martinez-Rugerio
7. Julian Kwan
8. Ryan Hekman
9. Andrew Emili
10. Thomas D. Gilmore
11. Sarah W. Davies

Reviewed by Arcadia Science

Slowest possible replicative life at frigid temperatures for yeast

1. Diederik S. Laman Trip
2. Théo Maire
3. Hyun Youk

Reviewed by Arcadia Science

Multiple Protein Structure Alignment at Scale with FoldMason

1. Cameron L.M. Gilchrist
2. Milot Mirdita
3. Martin Steinegger

Reviewed by Arcadia Science

Macroscopic label-free biomedical imaging with shortwave infrared Raman scattering

1. Bernardo A. Arús
2. Joycelyn Yiu
3. Jakob G. P. Lingg
4. Anja Hofmann
5. Amy R. Fumo
6. Honglei Ji
7. Carolin Jethwa
8. Roy K. Park
9. James Henderson
10. Kanuj Mishra
11. Iuliia Mukha
12. Andre C. Stiel
13. Donato Santovito
14. Christian Weber
15. Christian Reeps
16. Maria Rohm
17. Alexander Bartelt
18. Tulio A. Valdez
19. Andriy Chmyrov
20. Oliver T. Bruns

Reviewed by Arcadia Science

Genomic localization bias of secondary metabolite gene clusters and association with histone modifications in Aspergillus

1. Xin Zhang
2. Iseult Leahy
3. Jérȏme Collemare
4. Michael F. Seidl

Reviewed by Arcadia Science

Secondary metabolite profiling of Pseudomonas aeruginosa isolates reveals rare genomic traits

1. Rachel L Neve
2. Emily Giedraitis
3. Madeline S Akbari
4. Shirli Cohen
5. Vanessa V. Phelan

Reviewed by Arcadia Science

Experimental bleaching of photosymbiotic amoeba revealed strain-dependent differences in algal symbiosis ability

1. Daisuke Yamagishi
2. Ryo Onuma
3. Sachihiro Matsunaga
4. Shin-ya Miyagishima
5. Shinichiro Maruyama

Reviewed by Arcadia Science