Evaluated articles

Development of a fluorescence reporter system to quantify transcriptional activity of endogenous p53 in living cells

1. Tatsuki Tsuruoka
2. Emiri Nakayama
3. Takuya Endo
4. Shingo Harashima
5. Rui Kamada
6. Kazuyasu Sakaguchi
7. Toshiaki Imagawa

Reviewed by Arcadia Science

On the Origin and Evolution of Microbial Mercury Methylation

1. Heyu Lin
2. Edmund R R Moody
3. Tom A Williams
4. John W Moreau

Reviewed by Arcadia Science

Emergent coexistence in multispecies microbial communities

1. Chang-Yu Chang
2. Djordje Bajić
3. Jean C. C. Vila
4. Sylvie Estrela
5. Alvaro Sanchez

Reviewed by Arcadia Science

Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state

1. Maxwell H. Packebush
2. Silvia Sanchez-Martinez
3. Sourav Biswas
4. KC Shraddha
5. Kenny Nguyen
6. Thomas C. Boothby

Reviewed by Arcadia Science

CRISPR/Cas9 mediated gene editing in non-model nematode Panagrolaimus sp. PS1159

1. Viktoria Hellekes
2. Denise Claus
3. Johanna Seiler
4. Felix Illner
5. Philipp H. Schiffer
6. Michael Kroiher

Reviewed by Arcadia Science

Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities

1. Sabrina Ninck
2. Thomas Klaus
3. Tatiana V. Kochetkova
4. Sarah P. Esser
5. Leonard Sewald
6. Farnusch Kaschani
7. Christopher Bräsen
8. Alexander J. Probst
9. Ilya V. Kublanov
10. Bettina Siebers
11. Markus Kaiser

Reviewed by Arcadia Science

Biologically informed variational autoencoders allow predictive modeling of genetic and drug-induced perturbations

1. Daria Doncevic
2. Carl Herrmann

Reviewed by Arcadia Science

Sex-specificity of the C. elegans metabolome

1. Russell N. Burkhardt
2. Alexander B. Artyukhin
3. Erin Z. Aprison
4. Brian J. Curtis
5. Bennett W. Fox
6. Andreas H. Ludewig
7. Diana Fajardo Palomino
8. Jintao Luo
9. Amaresh Chaturbedi
10. Oishika Panda
11. Chester J. J. Wrobel
12. Victor Baumann
13. Douglas S. Portman
14. Siu Sylvia Lee
15. Ilya Ruvinsky
16. Frank C. Schroeder

Reviewed by Arcadia Science

Co-Occurrence and Cooperation between Comammox and Anammox Bacteria in a Full-Scale Attached Growth Municipal Wastewater Treatment Process

1. Katherine Vilardi
2. Irmarie Cotto
3. Megan Bachmann
4. Mike Parsons
5. Stephanie Klaus
6. Christopher Wilson
7. Charles B. Bott
8. Kelsey J. Pieper
9. Ameet J. Pinto

Reviewed by Arcadia Science

High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer

1. Anaísa B. Moreno
2. Viktor Ek
3. Jens Eriksson
4. Mikael E. Sellin
5. Lionel Guy

Reviewed by Arcadia Science

Multiple paths toward repeated phenotypic evolution in the spiny‐leg adaptive radiation ( Tetragnatha ; Hawai'i)

1. José Cerca
2. Darko D. Cotoras
3. Cindy G. Santander
4. Vanessa C. Bieker
5. Leke Hutchins
6. Jaime Morin‐Lagos
7. Carlos F. Prada
8. Susan Kennedy
9. Henrik Krehenwinkel
10. Andrew J. Rominger
11. Joana Meier
12. Dimitar Dimitrov
13. Torsten H. Struck
14. Rosemary G. Gillespie

Reviewed by Arcadia Science

Identification of green lineage osmotic stress pathways

1. Josep Vilarrasa-Blasi
2. Tamara Vellosillo
3. Robert E. Jinkerson
4. Friedrich Fauser
5. Tingting Xiang
6. Benjamin B. Minkoff
7. Lianyong Wang
8. Kiril Kniazev
9. Michael Guzman
10. Jacqueline Osaki
11. Michael R. Sussman
12. Martin C. Jonikas
13. José R. Dinneny

Reviewed by Arcadia Science

The adherens junction proteins α-catenin, vinculin and VASP cooperate to promote actin assembly

1. Rayan Said
2. Hong Wang
3. Julien Pernier
4. Hemalatha Narassimprakash
5. Stéphane Roméro
6. Alexis M. Gautreau
7. René-Marc Mège
8. Christophe Le Clainche

Reviewed by Arcadia Science

Chemical factors induce aggregative multicellularity in a close unicellular relative of animals

1. Núria Ros-Rocher
2. Ria Q. Kidner
3. Catherine Gerdt
4. W. Sean Davidson
5. Iñaki Ruiz-Trillo
6. Joseph P. Gerdt

Reviewed by Arcadia Science

FISHing for Rickettsia in tardigrades: additional evidence for tardigrade endosymbionts

1. Bienvenido W Tibbs-Cortes
2. Dylan L Schultz
3. Laura E Tibbs-Cortes
4. Stephan Schmitz-Esser

Reviewed by Arcadia Science

MuDoGeR: Multi-Domain Genome Recovery from metagenomes made easy

1. Ulisses Nunes da Rocha
2. Jonas Coelho Kasmanas
3. René Kallies
4. Joao Pedro Saraiva
5. Rodolfo Brizola Toscan
6. Polonca Štefanič
7. Marcos Fleming Bicalho
8. Felipe Borim Correa
9. Merve Nida Baştürk
10. Efthymios Fousekis
11. Luiz Miguel Viana Barbosa
12. Julia Plewka
13. Alexander Probst
14. Petr Baldrian
15. Peter Stadler
16. CLUE-TERRA consortium

Reviewed by Arcadia Science

Endozoicomonas -chlamydiae interactions in cell-associated microbial aggregates of the coral Pocillopora acuta

1. Justin Maire
2. Kshitij Tandon
3. Astrid Collingro
4. Allison van de Meene
5. Katarina Damjanovic
6. Cecilie Ravn Gøtze
7. Sophie Stephenson
8. Gayle K. Philip
9. Matthias Horn
10. Neal E. Cantin
11. Linda L. Blackall
12. Madeleine J. H. van Oppen

Reviewed by Arcadia Science

Unsupervised reference-free inference reveals unrecognized regulated transcriptomic complexity in human single cells

1. Roozbeh Dehghannasiri
2. George Henderson
3. Rob Bierman
4. Tavor Baharav
5. Kaitlin Chaung
6. Peter Wang
7. Julia Salzman

• Curated by eLife

  eLife Assessment

  This study presents a valuable advance for the analysis of gene expression variation at the level of individual cells by introducing a novel reference-free framework that can detect splicing, fusion, editing, immune-receptor diversity and repeated elements in sequencing data. The evidence supporting these claims is solid, with rigorous validation on simulated datasets and extensive analysis of full-length single-cell sequencing data demonstrating improved performance over existing methods. This work will be of particular interest to researchers developing methods for high-resolution transcriptome analysis and to those studying cellular heterogeneity in health and disease.

Reviewed by eLife, Arcadia Science

Identifying Eukaryotes and Factors Influencing Their Biogeography in Drinking Water Metagenomes

1. Marco Gabrielli
2. Zihan Dai
3. Vincent Delafont
4. Peer H. A. Timmers
5. Paul W. J. J. van der Wielen
6. Manuela Antonelli
7. Ameet J. Pinto

Reviewed by Arcadia Science

ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

1. Katarzyna Bogucka-Janczi
2. Gregory Harms
3. Marie-May Coissieux
4. Mohamed Bentires-Alj
5. Bernd Thiede
6. Krishnaraj Rajalingam

• Curated by eLife

  eLife assessment

  The manuscript describes a fundamental study of the atypical MAPK, ERK3, in the activation of RhoGTPase Cdc42 and the formation of actin-rich protrusions and cell migration. The results show that ERK3 is required for the motility of tumor cells in vivo, providing a new target for fighting metastasis.

Reviewed by Arcadia Science, eLife