Evaluated articles

High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models

1. Thomas J O'Brien
2. Ida L Barlow
3. Luigi Feriani
4. André EX Brown

• Curated by eLife

  eLife Assessment

  This important study provides proof of principle that C. elegans models can be used to accelerate the discovery of candidate treatments for human Mendelian diseases by detailed high-throughput phenotyping of strains harboring mutations in orthologs of human disease genes. The data are compelling and support an approach that enables the potential rapid repurposing of FDA-approved drugs to treat rare diseases for which there are currently no effective treatments. The work will be of interest to all geneticists.

Reviewed by eLife, Arcadia Science

Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo

1. Yizhou Zhuo
2. Bin Luo
3. Xinyang Yi
4. Hui Dong
5. Xiaolei Miao
6. Jinxia Wan
7. John T. Williams
8. Malcolm G. Campbell
9. Ruyi Cai
10. Tongrui Qian
11. Fengling Li
12. Sophia J. Weber
13. Lei Wang
14. Bozhi Li
15. Yu Wei
16. Guochuan Li
17. Huan Wang
18. Yu Zheng
19. Yulin Zhao
20. Marina E. Wolf
21. Yingjie Zhu
22. Mitsuko Watabe-Uchida
23. Yulong Li

Reviewed by Arcadia Science

Comparison of de novo and reference genome-based transcriptome assembly pipelines for differential expression analysis of RNA sequencing data

1. Rebekah A. Oomen
2. Halvor Knutsen
3. Esben M. Olsen
4. Sissel Jentoft
5. Nils Chr. Stenseth
6. Jeffrey A. Hutchings

Reviewed by Arcadia Science

Targeted decontamination of sequencing data with CLEAN

1. Marie Lataretu
2. Sebastian Krautwurst
3. Matthew R Huska
4. Mike Marquet
5. Adrian Viehweger
6. Sascha D Braun
7. Christian Brandt
8. Martin Hölzer

Reviewed by Arcadia Science

Epithelial Ca ²⁺ waves triggered by enteric neurons heal the gut

1. Afroditi Petsakou
2. Yifang Liu
3. Ying Liu
4. Aram Comjean
5. Yanhui Hu
6. Norbert Perrimon

Reviewed by Arcadia Science

Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus

1. Peter Rupprecht
2. Sian N. Duss
3. Denise Becker
4. Christopher M. Lewis
5. Johannes Bohacek
6. Fritjof Helmchen

Reviewed by Arcadia Science

Binding and sequestration of poison frog alkaloids by a plasma globulin

1. Aurora Alvarez-Buylla
2. Marie-Therese Fischer
3. Maria Dolores Moya Garzon
4. Alexandra E Rangel
5. Elicio E Tapia
6. Julia T Tanzo
7. H Tom Soh
8. Luis A Coloma
9. Jonathan Z Long
10. Lauren A O'Connell

• Curated by eLife

  eLife assessment

  Poison frogs sequester alkaloids to make themselves toxic or unpalatable to predators, but how this sequestration occurs is not well understood. This valuable study identifies an alkaloid-binding protein in the plasma of poison frogs, which may help explain how these animals are able to sequester a diversity of alkaloids with different target sites. The supporting evidence is solid and the study adds to our understanding of how toxic animals resist the effects of their own defenses.

Reviewed by eLife, Arcadia Science

Non-invasive Analysis of Peptidoglycan from Living Animals

1. Karl L. Ocius
2. Sree H. Kolli
3. Saadman S. Ahmad
4. Jules M. Dressler
5. Mahendra D. Chordia
6. Brandon L. Jutras
7. Melanie R. Rutkowski
8. Marcos M. Pires

Reviewed by Arcadia Science

Characterization of a selective, iron-chelating antifungal compound that disrupts fungal metabolism and synergizes with fluconazole

1. Jeanne Corrales
2. Lucia Ramos-Alonso
3. Javier González-Sabín
4. Nicolás Ríos-Lombardía
5. Nuria Trevijano-Contador
6. Henriette Engen Berg
7. Frøydis Sved Skottvoll
8. Francisco Moris
9. Oscar Zaragoza
10. Pierre Chymkowitch
11. Ignacio Garcia
12. Jorrit M. Enserink

Reviewed by Arcadia Science

MetaCerberus: distributed highly parallelized scalable HMM-based implementation for robust functional annotation across the tree of life

1. Jose L. Figueroa
2. Eliza Dhungel
3. Cory R. Brouwer
4. Richard Allen White

Reviewed by Arcadia Science

Acute dorsal genital nerve stimulation increases subjective arousal in women with and without spinal cord injury: a preliminary investigation

1. Elizabeth C. Bottorff
2. Priyanka Gupta
3. Giulia M. Ippolito
4. Mackenzie B. Moore
5. Gianna M. Rodriguez
6. Tim M. Bruns

Reviewed by Arcadia Science

Secretory protein Rv1987, a ‘probable chitinase’ from Mycobacterium tuberculosis is a novel chitin and cellulose binding protein lacking enzymatic function

1. Chiranth M. Prakash
2. Vani Janakiraman

Reviewed by Arcadia Science

iMOUSE - Reforming the Strategy of Refinement and Reduction for indispensable laboratory animal-based studies in translational research

1. Maciej Łaz
2. Mirko Lampe
3. Isaac Connor
4. Dmytro Shestachuk
5. Marcel Ludwig
6. Ursula Müller
7. Oliver F. Strauch
8. Nadine Suendermann
9. Stefan Lüth
10. Janine Kah

Reviewed by Arcadia Science

Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch

1. Andrew J. Crowther
2. Sakeen W. Kashem
3. Madison E. Jewell
4. Henry Le Chang
5. Mariela Rosa Casillas
6. Élora Midavaine
7. Sian Rodriguez
8. Joao M. Braz
9. Artur Kania
10. Allan I. Basbaum

Reviewed by Arcadia Science

The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function

1. Tracy-Ann Read
2. Bruno A Cisterna
3. Kristen Skruber
4. Samah Ahmadieh
5. Tatiana M Liu
6. Josefine A Vitriol
7. Yang Shi
8. Joseph B Black
9. Mitchell T Butler
10. Halli L Lindamood
11. Austin EYT Lefebvre
12. Alena Cherezova
13. Daria V Ilatovskaya
14. James E Bear
15. Neal L Weintraub
16. Eric A Vitriol

Reviewed by Arcadia Science

Krause corpuscles of the genitalia are vibrotactile sensors required for normal sexual behavior

1. Lijun Qi
2. Michael Iskols
3. Annie Handler
4. David D. Ginty

Reviewed by Arcadia Science

Extracellular vesicles are the main contributor to the non-viral protected extracellular sequence space

1. Dominik Lücking
2. Coraline Mercier
3. Tomas Alarcón-Schumacher
4. Susanne Erdmann

Reviewed by Arcadia Science

A Rationally Designed Antimicrobial Peptide from Structural and Functional Insight of Clostridium difficile Translation Initiation Factor 1

1. Elvira Alanis
2. Faith Aguilar
3. Niaz Banaei
4. Frank B. Dean
5. Miguel Alanis
6. James M. Bullard
7. Yonghong Zhang

Reviewed by Arcadia Science

A Bright, Photostable Dye that Enables Multicolor, Time Lapse, and Super-Resolution Imaging of Acidic Organelles

1. Lauren Lesiak
2. Neville Dadina
3. Shuai Zheng
4. Marianne Schelvis
5. Alanna Schepartz

Reviewed by Arcadia Science

Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster

1. Richard F. Lyman
2. Rachel A. Lyman
3. Akihiko Yamamoto
4. Wen Huang
5. Susan T. Harbison
6. Shanshan Zhou
7. Robert R. H. Anholt
8. Trudy F. C. Mackay

Reviewed by Arcadia Science