Evaluated articles

Biophysical mechanism of ultrafast helical twisting contraction in the giant unicellular ciliate Spirostomum ambiguum

1. L. X. Xu
2. M. S. Bhamla

Reviewed by Arcadia Science

Cooperative growth in microbial communities is a driver of multistability

1. William Lopes
2. Daniel R. Amor
3. Jeff Gore

Reviewed by Arcadia Science

Disease-associated astrocyte epigenetic memory promotes CNS pathology

1. Hong-Gyun Lee
2. Joseph M. Rone
3. Zhaorong Li
4. Camilo Faust Akl
5. Seung Won Shin
6. Joon-Hyuk Lee
7. Lucas E. Flausino
8. Florian Pernin
9. Chun-Cheih Chao
10. Kilian L. Kleemann
11. Lena Srun
12. Tomer Illouz
13. Federico Giovannoni
14. Marc Charabati
15. Liliana M. Sanmarco
16. Jessica E. Kenison
17. Gavin Piester
18. Stephanie E. J. Zandee
19. Jack P. Antel
20. Veit Rothhammer
21. Michael A. Wheeler
22. Alexandre Prat
23. Iain C. Clark
24. Francisco J. Quintana

Reviewed by Arcadia Science

Sweet and fatty symbionts: photosynthetic productivity and carbon storage boosted in microalgae within a host

1. A. Catacora-Grundy
2. F. Chevalier
3. D. Yee
4. C. LeKieffre
5. N. L. Schieber
6. Y. Schwab
7. B. Gallet
8. P.H. Jouneau
9. G. Curien
10. J. Decelle

Reviewed by Arcadia Science

Comparative Hox genes expression within the dimorphic annelid Streblospio benedicti reveals patterning variation during development

1. Jose Maria Aguilar-Camacho
2. Nathan D. Harry
3. Christina Zakas

Reviewed by Arcadia Science

A benchmark for large language models in bioinformatics

1. Varuni Sarwal
2. Gaia Andreoletti
3. Viorel Munteanu
4. Ariel Suhodolschi
5. Dumitru Ciorba
6. Viorel Bostan
7. Mihai Dimian
8. Eleazar Eskin
9. Wei Wang
10. Serghei Mangul

Reviewed by Arcadia Science

Development of a sensor for disulfide bond formation in diverse bacteria

1. Jocelyne Mendoza
2. Dyotima
3. Sally Abulaila
4. Cristina Landeta

Reviewed by Arcadia Science

Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction

1. James Boocock
2. Noah Alexander
3. Leslie Alamo Tapia
4. Laura Walter-McNeill
5. Shivani Prashant Patel
6. Chetan Munugala
7. Joshua S Bloom
8. Leonid Kruglyak

• Curated by eLife

  eLife assessment

  This manuscript describes the mapping of natural DNA sequence variants that affect gene expression and its noise, as well as cell cycle timing, using as input single-cell RNA-sequencing of progeny from crosses between wild yeast strains. The method represents an important advance in the study of natural genetic variation. The findings, especially given the follow-up validation of the phenotypic impact of a mapped locus of major effect, provide convincing support for the rigor and utility of the method.

Reviewed by eLife, Arcadia Science

RamanSPy: An Open-Source Python Package for Integrative Raman Spectroscopy Data Analysis

1. Dimitar Georgiev
2. Simon Vilms Pedersen
3. Ruoxiao Xie
4. Álvaro Fernández-Galiana
5. Molly M. Stevens
6. Mauricio Barahona

Reviewed by Arcadia Science

Technical upgrade of an open-source liquid handler to support bacterial colony screening

1. Irene del Olmo
2. Pablo Yubero
3. Álvaro Gómez-Luengo
4. Juan Nogales
5. David R. Espeso

Reviewed by Arcadia Science

Functional annotation hypothetical proteins: a world to be explored in drug development in Trypanosomatids

1. Raissa Santos de Lima
2. Ana Carolina Silva Bulla
3. Manuela Leal da Silva

Reviewed by Arcadia Science

Nanos2+ cells give rise to germline and somatic lineages in the sea anemone Nematostella vectensis

1. Andreas Denner
2. Julia Steger
3. Alexander Ries
4. Elizaveta Morozova-Link
5. Josefine Ritter
6. Franziska Haas
7. Alison G. Cole
8. Ulrich Technau

Reviewed by Arcadia Science

Beyond blast: enabling microbiologists to better extract literature, taxonomic distributions and gene neighbourhood information for protein families

1. Colbie J. Reed
2. Rémi Denise
3. Jacob Hourihan
4. Jill Babor
5. Marshall Jaroch
6. Maria Martinelli
7. Geoffrey Hutinet
8. Valérie de Crécy-Lagard

Reviewed by Arcadia Science

Novel Association of Lyme disease, Age, and Atopic Dermatitis

1. Brandon T. Lee
2. Sarah D. Galloway
3. Qingying Feng
4. Satu Strausz
5. Maia Shoham
6. Paige Hansen
7. Laughing Bear Torrez Dulgeroff
8. Grace Blacker
9. Ying Y. Yiu
10. Paul Mansfield
11. FinnGen
12. Atif Saleem
13. Eric Gars
14. Erin C. Sanders
15. Irving L. Weissman
16. Hanna M. Ollila
17. Michal Caspi Tal

Reviewed by Arcadia Science

Alternative splicing across the tree of life

1. Rebeca de la Fuente
2. Wladimiro Dı́az-Villanueva
3. Vicente Arnau
4. Andres Moya

• Curated by eLife

  eLife Assessment

  The authors examined the frequency of alternative splicing across prokaryotes and eukaryotes and found that the rate of alternative splicing varies with taxonomic groups and genome coding content. This solid work, based on nearly 1,500 high-quality genome assemblies, relies on a novel genome-scale metric that enables cross-species comparisons and that quantifies the extent to which coding sequences generate multiple mRNA transcripts via alternative splicing. This timely study provides an important basis for improving our general understanding of genome architecture and the evolution of life forms.

Reviewed by eLife, Arcadia Science

Disruption of Polycystin Ciliary Localization and Channel Function by Autosomal Dominant Polycystic Kidney Disease–Causing Polycystin-1 Variants

1. Kotdaji Ha
2. Gabriel B. Loeb
3. Meyeon Park
4. Mohona Gupta
5. Yukako Akiyama
6. Jillian Argiris
7. Aide Pinedo
8. Christine Haewon Park
9. Nadav Brandes
10. Fnu Ritu
11. Chun Jimmie Ye
12. Willow Coyote-Maestas
13. Jeremy F. Reiter
14. Markus Delling

Reviewed by Arcadia Science

Contextual and combinatorial structure in sperm whale vocalisations

1. Pratyusha Sharma
2. Shane Gero
3. Roger Payne
4. David F. Gruber
5. Daniela Rus
6. Antonio Torralba
7. Jacob Andreas

Reviewed by Arcadia Science

A joint embedding of protein sequence and structure enables robust variant effect predictions

1. Lasse M. Blaabjerg
2. Nicolas Jonsson
3. Wouter Boomsma
4. Amelie Stein
5. Kresten Lindorff-Larsen

Reviewed by Arcadia Science

Engram reactivation mimics cellular signatures of fear

1. Rebecca L. Suthard
2. Ryan A. Senne
3. Michelle D. Buzharsky
4. Anh H. Diep
5. Angela Y. Pyo
6. Steve Ramirez

Reviewed by Arcadia Science

FAIR Header Reference genome: a TRUSTworthy standard

1. Adam Wright
2. Mark D Wilkinson
3. Christopher Mungall
4. Scott Cain
5. Stephen Richards
6. Paul Sternberg
7. Ellen Provin
8. Jonathan L Jacobs
9. Scott Geib
10. Daniela Raciti
11. Karen Yook
12. Lincoln Stein
13. David C Molik

Reviewed by Arcadia Science