Evaluated articles

Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway

1. M. Elizabeth Deerhake
2. Keiko Danzaki
3. Makoto Inoue
4. Emre D. Cardakli
5. Toshiaki Nonaka
6. Nupur Aggarwal
7. William E. Barclay
8. Ru Rong Ji
9. Mari L. Shinohara

Reviewed by preLights

STING mediates immune responses in the closest living relatives of animals

1. Arielle Woznica
2. Ashwani Kumar
3. Carolyn R Sturge
4. Chao Xing
5. Nicole King
6. Julie K Pfeiffer

• Curated by eLife

  Evaluation Summary:

  The authors addressed the role of a STING ortholog in antimicrobial defense of choanoflagellates. The analysis of the response of the choanoflagellate Monosiga brevicollis to a variety of bacterial species revealed that exposure of M. brevicollis to Pseudomonas aeruginosa conditioned medium results in choanoflagellate death and the authors found that this is dependent on the newly discovered ortholog of STING. Characterization reveals that the STING response can be induced by 2'3' cGAMP, which parallels the activation of STING in diverse species. In addition, the finding that cyclic dinucleotide treatment induces autophagy also has parallels with the effector pathways observed in other organisms. There are a number of strengths as outlined by the Reviewers. First, the development of a Choanaoflagellate model system to study innate immunity, second with the development of genetics for M. brevicollis, third, the demonstration of a functional STING system in one of the closest relatives to animals and fourth, that cell death occurs in response to cyclic dinucleotides.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, preLights

Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays

1. Guillermina R. Ramirez-San Juan
2. Arnold J. T. M. Mathijssen
3. Mu He
4. Lily Jan
5. Wallace Marshall
6. Manu Prakash

Reviewed by preLights

High survival following bleaching highlights the resilience of a highly disturbed region of the Great Barrier Reef

1. Cathie A Page
2. Christine Giuliano
3. Line K Bay
4. Carly J Randall

Reviewed by preLights

A spatially resolved single cell atlas of human gastrulation

1. Richard C.V. Tyser
2. Elmir Mahammadov
3. Shota Nakanoh
4. Ludovic Vallier
5. Antonio Scialdone
6. Shankar Srinivas

Reviewed by preLights

Antlions are sensitive to subnanometer amplitude vibrations carried by sand substrates

1. Vanessa Martinez
2. Elise Nowbahari
3. David Sillam-Dussès
4. Vincent Lorent

Reviewed by preLights

Utah-Stanford Ventilator (Vent4US): Developing a rapidly scalable ventilator for COVID-19 patients with ARDS

1. Hongquan Li
2. Ethan Li
3. Deepak Krishnamurthy
4. Patrick Kolbay
5. Beca Chacin
6. Soeren Hoehne
7. Jim Cybulski
8. Lara Brewer
9. Tomasz Petelenz
10. Joseph Orr
11. Derek Sakata
12. Thomas Clardy
13. Kai Kuck
14. Manu Prakash

Reviewed by ScreenIT, preLights

Evolutionary Changes in Left-Right Visceral Asymmetry in Astyanax Cavefish

1. Li Ma
2. Mandy Ng
3. Janet Shi
4. Aniket V. Gore
5. Daniel Castranova
6. Brant M. Weinstein
7. William R. Jeffery

Reviewed by preLights

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

1. Miles K. Huseyin
2. Robert J. Klose

Reviewed by preLights

Tumors Exploit Dedicated Intracellular Vesicles to Program T cell Responses

1. Edward W. Roberts
2. Megan K. Ruhland
3. En Cai
4. Adriana M. Mujal
5. Kyle Marchuk
6. Casey Beppler
7. David Nam
8. Nina K. Serwas
9. Mikhail Binnewies
10. Matthew F. Krummel

Reviewed by preLights

Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice

1. Jerome A. J. Becker
2. Lucie P. Pellissier
3. Yannick Corde
4. Thibaut Laboute
5. Audrey Léauté
6. Jorge Gandía
7. Julie Le Merrer

Reviewed by preLights

Preformed chromatin topology assists transcriptional robustness of Shh during limb development

1. Christina Paliou
2. Philine Guckelberger
3. Robert Schöpflin
4. Verena Heinrich
5. Andrea Esposito
6. Andrea M. Chiariello
7. Simona Bianco
8. Carlo Annunziatella
9. Johannes Helmuth
10. Stefan Haas
11. Ivana Jerković
12. Norbert Brieske
13. Lars Wittler
14. Bernd Timmermann
15. Mario Nicodemi
16. Martin Vingron
17. Stefan Mundlos
18. Guillaume Andrey

Reviewed by preLights

Cross-kingdom recognition of bacterial small RNAs induces transgenerational pathogenic avoidance

1. Rachel Kaletsky
2. Rebecca S. Moore
3. Lance L. Parsons
4. Coleen T. Murphy

Reviewed by preLights

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

1. Charles L. Evavold
2. Iva Hafner-Bratkovič
3. Pascal Devant
4. Jasmin M. D’Andrea
5. Elsy M. Ngwa
6. Elvira Boršić
7. John G. Doench
8. Martin W. LaFleur
9. Arlene H. Sharpe
10. Jay R. Thiagarajah
11. Jonathan C. Kagan

Reviewed by preLights

Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells

1. Maria Montserrat Garcia Romero
2. Gareth McCathie
3. Philip Jankun
4. Henry Hamilton Roehl

Reviewed by preLights

Coordination of tissue cell polarity by auxin transport and signaling

1. Carla Verna
2. Sree Janani Ravichandran
3. Megan G Sawchuk
4. Nguyen Manh Linh
5. Enrico Scarpella

Reviewed by preLights

Trackosome: a computational toolbox to study the spatiotemporal dynamics of centrosomes, nuclear envelope and cellular membrane

1. Domingos Castro
2. Vanessa Nunes
3. Joana T. Lima
4. Jorge G. Ferreira
5. Paulo Aguiar

Reviewed by preLights

Distinct RopGEFs Successively Drive Polarization and Outgrowth of Root Hairs

1. Philipp Denninger
2. Anna Reichelt
3. Vanessa A.F. Schmidt
4. Dietmar G. Mehlhorn
5. Lisa Y. Asseck
6. Claire E. Stanley
7. Nana F. Keinath
8. Jan-Felix Evers
9. Christopher Grefen
10. Guido Grossmann

Reviewed by preLights

Species-specific developmental timing is associated with global differences in protein stability in mouse and human

1. Teresa Rayon
2. Despina Stamataki
3. Ruben Perez-Carrasco
4. Lorena Garcia-Perez
5. Christopher Barrington
6. Manuela Melchionda
7. Katherine Exelby
8. Victor Tybulewicz
9. Elizabeth M. C. Fisher
10. James Briscoe

Reviewed by preLights

Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids

1. John A. Smolka
2. Lionel A. Sanz
3. Stella R. Hartono
4. Frédéric Chédin

Reviewed by preLights