Evaluated articles

Constricted migration is associated with stable 3D genome structure differences in cancer cells

1. Rosela Golloshi
2. Christopher Playter
3. Trevor F Freeman
4. Priyojit Das
5. Thomas Isaac Raines
6. Joshua H Garretson
7. Delaney Thurston
8. Rachel Patton McCord

Reviewed by preLights

Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement

1. Helen K. Matthews
2. Sushila Ganguli
3. Katarzyna Plak
4. Anna V. Taubenberger
5. Zaw Win
6. Max Williamson
7. Matthieu Piel
8. Jochen Guck
9. Buzz Baum

Reviewed by preLights

PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore

1. Richard J. Smith
2. Marilia H. Cordeiro
3. Norman E. Davey
4. Giulia Vallardi
5. Andrea Ciliberto
6. Fridolin Gross
7. Adrian T. Saurin

Reviewed by preLights

Sexually dimorphic DNA damage responses and mutation avoidance in the mouse germline

1. Jordana C. Bloom
2. John C. Schimenti

Reviewed by preLights

An Endocytic Capture Model for Skeletal Muscle T-tubule Formation

1. Thomas E Hall
2. Nick Martel
3. Nicholas Ariotti
4. Zherui Xiong
5. Harriet P Lo
6. Charles Ferguson
7. James Rae
8. Ye-Wheen Lim
9. Robert G Parton

Reviewed by preLights

Akt/Foxo pathway activation switches apoptosis to senescence in short telomere zebrafish

1. Mounir El-Maï
2. Marta Marzullo
3. Inês Pimenta de Castro
4. Miguel Godinho Ferreira

Reviewed by preLights

Cardioids reveal self-organizing principles of human cardiogenesis

1. Pablo Hofbauer
2. Stefan M. Jahnel
3. Nora Papai
4. Magdalena Giesshammer
5. Alison Deyett
6. Clara Schmidt
7. Mirjam Penc
8. Katherina Tavernini
9. Nastasja Grdseloff
10. Christy Meledeth
11. Lavinia Ceci Ginistrelli
12. Claudia Ctortecka
13. Šejla Šalic
14. Maria Novatchkova
15. Sasha Mendjan

Reviewed by preLights

Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis

1. John K. Eykelenboom
2. Marek Gierliński
3. Zuojun Yue
4. Nadia Hegarat
5. Hilary Pollard
6. Tatsuo Fukagawa
7. Helfrid Hochegger
8. Tomoyuki U. Tanaka

Reviewed by preLights

Breaking the next Cryo-EM resolution barrier – Atomic resolution determination of proteins!

1. Ka Man Yip
2. Niels Fischer
3. Elham Paknia
4. Ashwin Chari
5. Holger Stark

Reviewed by preLights

Modulation of β-catenin levels is critical for cranial neural crest patterning and dispersal into first pharyngeal arch

1. Alok Javali
2. Vairavan Laxmanan
3. Dasaradhi Palakodeti
4. Ramkumar Sambasivan

Reviewed by preLights

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

1. Prashant Rajbhandari
2. Douglas Arneson
3. Sydney K Hart
4. In Sook Ahn
5. Graciel Diamante
6. Luis C Santos
7. Nima Zaghari
8. An-Chieh Feng
9. Brandon J Thomas
10. Laurent Vergnes
11. Stephen D Lee
12. Abha K Rajbhandari
13. Karen Reue
14. Stephen T Smale
15. Xia Yang
16. Peter Tontonoz

Reviewed by preLights

A subcellular atlas of Toxoplasma reveals the functional context of the proteome

1. Konstantin Barylyuk
2. Ludek Koreny
3. Huiling Ke
4. Simon Butterworth
5. Oliver M. Crook
6. Imen Lassadi
7. Vipul Gupta
8. Eelco Tromer
9. Tobias Mourier
10. Tim J. Stevens
11. Lisa M. Breckels
12. Arnab Pain
13. Kathryn S. Lilley
14. Ross F. Waller

Reviewed by preLights

Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly

1. Jemil Ahmed
2. Tessa C. Fitch
3. Courtney M. Donnelly
4. Johnson A. Joseph
5. Tyler D. Ball
6. Mikaela M. Bassil
7. Ahyun Son
8. Chen Zhang
9. Aurélie Ledreux
10. Scott Horowitz
11. Yan Qin
12. Daniel Paredes
13. Sunil Kumar

Reviewed by preLights

The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

1. Trisha A. Macrae
2. Miguel Ramalho-Santos

Reviewed by preLights

Transparency in peer review: Exploring the content and tone of reviewers’ confidential comments to editors

1. Bridget C. O’Brien
2. Anthony R. Artino
3. Joseph A. Costello
4. Erik Driessen
5. Lauren A. Maggio

Reviewed by preLights

A hydraulic instability drives the cell death decision in the nematode germline

1. Nicolas T. Chartier
2. Arghyadip Mukherjee
3. Julia Pfanzelter
4. Sebastian Fürthauer
5. Ben T. Larson
6. Anatol W. Fritsch
7. Rana Amini
8. Moritz Kreysing
9. Frank Jülicher
10. Stephan W. Grill

Reviewed by preLights

DRAM1 confers resistance to Salmonella infection

1. Samrah Masud
2. Jiajun Xie
3. Bart J.M. Grijmans
4. Sander van der Kooij
5. Rui Zhang
6. Tomasz K. Prajsnar
7. Annemarie H. Meijer

Reviewed by preLights

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

1. Rediet Zewdu
2. Elnaz Mirzaei Mehrabad
3. Kelley Ingram
4. Pengshu Fang
5. Katherine L Gillis
6. Soledad A Camolotto
7. Grace Orstad
8. Alex Jones
9. Michelle C Mendoza
10. Benjamin T Spike
11. Eric L Snyder

• Curated by eLife

  Evaluation Summary:

  This manuscript greatly expands our understanding of an aggressive subtype of lung cancer. The author use in vivo cancer models and extensive analysis of the cancer cells states to uncover aspects of differentiation, drug responses and pathway activation. Findings of the study will help in the development of lineage-specific targeted therapies against cancers.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, preLights

Small differences in learning speed for different food qualities can drive efficient collective foraging in ant colonies

1. F. B. Oberhauser
2. A. Koch
3. T. J. Czaczkes

Reviewed by preLights

The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

1. Ann-Kathrin Mehnert
2. Marco Prorocic
3. Annick Dujeancourt-Henry
4. Sebastian Hutchinson
5. Richard McCulloch
6. Lucy Glover

Reviewed by preLights