Evaluated articles

A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development

1. Ya’el Courtney
2. Joshua P. Head
3. Elizabeth D. Yimer
4. Neil Dani
5. Frederick B. Shipley
6. Towia A. Libermann
7. Maria K. Lehtinen

Reviewed by preLights

A revised single-cell transcriptomic atlas of Xenopus embryo reveals new differentiation dynamics

1. Kseniya Petrova
2. Maksym Tretiakov
3. Aleksandr Kotov
4. Anne H. Monsoro-Burq
5. Leonid Peshkin

Reviewed by preLights

An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility

1. Aki Teranishi
2. Misato Mori
3. Rihoko Ichiki
4. Satoshi Toda
5. Go Shioi
6. Satoru Okuda

Reviewed by preLights

Notch Is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth

1. Dylan J. Guerin
2. Belen Gutierrez
3. Baoyi Zhang
4. Kelly Ai-Sun Tseng

Reviewed by preLights

Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity

1. Jonathan Kuhn
2. Parijat Banerjee
3. Andrew Haye
4. Douglas N. Robinson
5. Pablo A. Iglesias
6. Peter N. Devreotes

Reviewed by preLights

Changes in surface temperatures reveal the thermal challenge associated with catastrophic moult in captive Gentoo penguins

1. Agnès Lewden
2. Tristan Halna du Fretay
3. Antoine Stier

Reviewed by preLights

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

1. Laura Santini
2. Saskia Kowald
3. Luis Miguel Cerron-Alvan
4. Michelle Huth
5. Anna Philina Fabing
6. Giovanni Sestini
7. Nicolas Rivron
8. Martin Leeb

Reviewed by preLights

Digital Microbe: A Genome-Informed Data Integration Framework for Collaborative Research on Emerging Model Organisms

1. Iva Veseli
2. Michelle A. DeMers
3. Zachary S. Cooper
4. Matthew S. Schechter
5. Samuel Miller
6. Laura Weber
7. Christa B. Smith
8. Lidimarie T. Rodriguez
9. William F. Schroer
10. Matthew R. McIlvin
11. Paloma Z. Lopez
12. Makoto Saito
13. Sonya Dyhrman
14. A. Murat Eren
15. Mary Ann Moran
16. Rogier Braakman

Reviewed by preLights

Lens placode modulates extracellular matrix formation during early eye development

1. Cecília G. De Magalhães
2. Ales Cvekl
3. Ruy G. Jaeger
4. C.Y. Irene Yan

Reviewed by preLights

DNA methylation enables recurrent endogenization of giant viruses in an animal relative

1. Luke A. Sarre
2. Iana V. Kim
3. Vladimir Ovchinnikov
4. Marine Olivetta
5. Hiroshi Suga
6. Omaya Dudin
7. Arnau Sebé-Pedrós
8. Alex de Mendoza

Reviewed by preLights

Learning a conserved mechanism for early neuroectoderm morphogenesis

1. Matthew Lefebvre
2. Jonathan Colen
3. Nikolas Claussen
4. Fridtjof Brauns
5. Marion Raich
6. Noah Mitchell
7. Michel Fruchart
8. Vincenzo Vitelli
9. Sebastian J Streichan

Reviewed by preLights

Experience-dependent plasticity of a highly specific olfactory circuit in Drosophila melanogaster

1. Benjamin Fabian
2. Veit Grabe
3. Rolf G. Beutel
4. Bill S. Hansson
5. Silke Sachse

Reviewed by preLights

A direct experimental test of Ohno’s hypothesis

1. Ljiljana Mihajlovic
2. Bharat Ravi Iyengar
3. Florian Baier
4. Içvara Barbier
5. Justyna Iwaszkiewicz
6. Vincent Zoete
7. Andreas Wagner
8. Yolanda Schaerli

• Curated by eLife

  eLife Assessment

  This fundamental study uses a creative experimental system to directly test Ohno's hypothesis, which describes how and why new genes might evolve by duplication of existing ones. In agreement with existing criticism of Ohno's original idea, the authors present compelling evidence that having two gene copies does not speed up the evolution of a new function as posited by Ohno, but instead leads to the rapid inactivation of one of the copies through the accumulation of mostly deleterious mutations. These findings will be of broad interest to evolutionary biologists and geneticists.

Reviewed by eLife, preLights

Characterization of Identified Dopaminergic Neurons in the Mouse Forebrain and Midbrain

1. Maggy Yu Hei Lau
2. Sana Gadiwalla
3. Susan Jones
4. Elisa Galliano

Reviewed by preLights

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

1. Jayne Aiken
2. Erika L. F. Holzbaur

Reviewed by preLights

Inference of drug off-target effects on cellular signaling using interactome-based deep learning

1. Nikolaos Meimetis
2. Douglas A. Lauffenburger
3. Avlant Nilsson

Reviewed by preLights

Hibernating ribosomes tether to mitochondria as an adaptive response to cellular stress during glucose depletion

1. Olivier Gemin
2. Maciej Gluc
3. Michael Purdy
4. Higor Rosa
5. Moritz Niemann
6. Yelena Peskova
7. Simone Mattei
8. Ahmad Jomaa

Reviewed by preLights

Structured RhoGEF recruitment drives myosin II organization on large exocytotic vesicles

1. Kumari Kamalesh
2. Dagan Segal
3. Ori Avinoam
4. Eyal D. Schejter
5. Ben-Zion Shilo

Reviewed by preLights

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

1. Hasan Mamar
2. Roberta Fajka-Boja
3. Mónika Mórocz
4. Eva Pinto Jurado
5. Siham Zentout
6. Alexandra Mihuț
7. Anna Georgina Kopasz
8. Mihály Mérey
9. Rebecca Smith
10. Lajos Haracska
11. Sébastien Huet
12. Gyula Timinszky

Reviewed by preLights

Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories

1. Jeanette A.I. Johnson
2. Daniel R. Bergman
3. Heber L. Rocha
4. David L. Zhou
5. Eric Cramer
6. Ian C. Mclean
7. Yoseph W. Dance
8. Max Booth
9. Zachary Nicholas
10. Tamara Lopez-Vidal
11. Atul Deshpande
12. Randy Heiland
13. Elmar Bucher
14. Fatemeh Shojaeian
15. Matthew Dunworth
16. André Forjaz
17. Michael Getz
18. Inês Godet
19. Furkan Kurtoglu
20. Melissa Lyman
21. John Metzcar
22. Jacob T. Mitchell
23. Andrew Raddatz
24. Jacobo Solorzano
25. Aneequa Sundus
26. Yafei Wang
27. David G. DeNardo
28. Andrew J. Ewald
29. Daniele M. Gilkes
30. Luciane T. Kagohara
31. Ashley L. Kiemen
32. Elizabeth D. Thompson
33. Denis Wirtz
34. Laura D. Wood
35. Pei-Hsun Wu
36. Neeha Zaidi
37. Lei Zheng
38. Jacquelyn W. Zimmerman
39. Jude M. Phillip
40. Elizabeth M. Jaffee
41. Joe W. Gray
42. Lisa M. Coussens
43. Young Hwan Chang
44. Laura M. Heiser
45. Genevieve L. Stein-O’Brien
46. Elana J. Fertig
47. Paul Macklin

Reviewed by preLights