Evaluated articles

Spatial and single-cell transcriptomics reveal neuron-astrocyte interplay in long-term memory

1. Wenfei Sun
2. Zhihui Liu
3. Xian Jiang
4. Michelle B. Chen
5. Hua Dong
6. Jonathan Liu
7. Thomas C. Südhof
8. Stephen R. Quake

Reviewed by preLights

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

1. Fumiyuki Hatanaka
2. Keiichiro Suzuki
3. Kensaku Shojima
4. Jingting Yu
5. Yuta Takahashi
6. Akihisa Sakamoto
7. Javier Prieto
8. Maxim Shokhirev
9. Estrella Nuñez Delicado
10. Concepcion Rodriguez Esteban
11. Juan Carlos Izpisua Belmonte

Reviewed by preLights

Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

1. Aleksandar Bartolome
2. Julia C Heiby
3. Domenico Di Fraia
4. Ivonne Heinze
5. Hannah Knaudt
6. Ellen Spaeth
7. Omid Omrani
8. Alberto Minetti
9. Maleen Hofmann
10. Joanna M Kirkpatrick
11. Therese Dau
12. Alessandro Ori

• Curated by eLife

  eLife assessment

  This study presents an important method and resource in cell lines and in mice for mass spectrometry-based identification of interactors of the proteasome, a multi-protein complex with a central role in protein turnover in almost all tissues and cell types. The method presented, including the experimental workflow and analysis pipeline, as well as the several lines of validation provided throughout, is convincing. Given the growing interest in protein aggregation and targeted protein degradation modalities, this work will be of interest to a broad spectrum of basic cell biologists and translational researchers.

Reviewed by eLife, preLights

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

1. Tao Cheng
2. Aruljothi Mariappan
3. Ewa Langner
4. Kyuhwan Shim
5. Jay Gopalakrishnan
6. Moe R. Mahjoub

Reviewed by preLights

Phospho-seq: integrated, multi-modal profiling of intracellular protein dynamics in single cells

1. John D. Blair
2. Austin Hartman
3. Fides Zenk
4. Philipp Wahle
5. Giovanna Brancati
6. Carol Dalgarno
7. Barbara Treutlein
8. Rahul Satija

Reviewed by preLights

From Policy to Practice: Tracking an Open Science Funding Initiative

1. Kristen Ratan
2. Souad McIntosh
3. Hetal V. Shah
4. Matt Lewis
5. Sonya B. Dumanis
6. Timothy H. Vines
7. Randy Schekman
8. Ekemini A Riley

Reviewed by preLights

A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion

1. Geena V. Ildefonso
2. Stacey D. Finley

Reviewed by preLights

Massively parallel protein-protein interaction measurement by sequencing (MP3-seq) enables rapid screening of protein heterodimers

1. Alexander Baryshev
2. Alyssa La Fleur
3. Benjamin Groves
4. Cirstyn Michel
5. David Baker
6. Ajasja Ljubetič
7. Georg Seelig

Reviewed by preLights

Flat clathrin lattices are linked to metastatic potential in colorectal cancer

1. Charlotte Cresens
2. Guillermo Solís-Fernández
3. Astha Tiwari
4. Rik Nuyts
5. Johan Hofkens
6. Rodrigo Barderas
7. Susana Rocha

Reviewed by preLights

Rapid response of fly populations to gene dosage across development and generations

1. Xueying C. Li
2. Lautaro Gandara
3. Måns Ekelöf
4. Kerstin Richter
5. Theodore Alexandrov
6. Justin Crocker

Reviewed by preLights

Mitotic heritability of DNA methylation at intermediately methylated sites is imprecise

1. Amir D. Hay
2. Noah J. Kessler
3. Daniel Gebert
4. Nozomi Takahashi
5. Hugo Tavares
6. Felipe K. Teixeira
7. Anne C. Ferguson-Smith

Reviewed by preLights

Humoral and T-cell-mediated responses to a pre-clinical Zika vaccine candidate that utilizes a unique insect-specific flavivirus platform

1. Danielle L. Porier
2. Awadalkareem Adam
3. Lin Kang
4. Pawel Michalak
5. Juselyn Tupik
6. Matthew A. Santos
7. Christy Lee
8. Irving C. Allen
9. Tian Wang
10. Albert J. Auguste

Reviewed by preLights

CTCF is essential for proper mitotic spindle structure and anaphase segregation

1. Katherine Chiu
2. Yasmin Berrada
3. Nebiyat Eskndir
4. Dasol Song
5. Claire Fong
6. Sarah Naughton
7. Tina Chen
8. Savanna Moy
9. Sarah Gyurmey
10. Liam James
11. Chimere Ezeiruaku
12. Caroline Capistran
13. Daniel Lowey
14. Vedang Diwanji
15. Samantha Peterson
16. Harshini Parakh
17. Ayanna R. Burgess
18. Cassandra Probert
19. Annie Zhu
20. Bryn Anderson
21. Nehora Levi
22. Gabi Gerlitz
23. Mary C. Packard
24. Katherine A. Dorfman
25. Michael Seifu Bahiru
26. Andrew D. Stephens

Reviewed by preLights

marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis

1. AP Francisco
2. I Tastekin
3. AB Fernandes
4. G Ezra-Nevo
5. B Deplancke
6. AJ Oliveira-Maia
7. AM Gontijo
8. C Ribeiro

Reviewed by preLights

Actin nucleators safeguard replication forks by limiting nascent strand degradation

1. Jadwiga Nieminuszczy
2. Peter R Martin
3. Ronan Broderick
4. Joanna Krwawicz
5. Alexandra Kanellou
6. Camelia Mocanu
7. Vicky Bousgouni
8. Charlotte Smith
9. Kuo-Kuang Wen
10. Beth L Woodward
11. Chris Bakal
12. Fiona Shackley
13. Andrés Aguilera
14. Grant S Stewart
15. Yatin M Vyas
16. Wojciech Niedzwiedz

Reviewed by preLights

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis

1. Daniel Salas-Lloret
2. Néstor García-Rodríguez
3. Emily Soto-Hidalgo
4. Lourdes González-Vinceiro
5. Carmen Espejo-Serrano
6. Lisanne Giebel
7. María Luisa Mateos-Martín
8. Arnoud H. de Ru
9. Peter A. van Veelen
10. Pablo Huertas
11. Alfred C. O. Vertegaal
12. Román González-Prieto

Reviewed by preLights

Quantification of gallium cryo-FIB milling damage in biological lamella

1. Bronwyn A. Lucas
2. Nikolaus Grigorieff

Reviewed by preLights

Coordinated growth of linked epithelia is mediated by the Hippo pathway

1. Sophia Friesen
2. Iswar K. Hariharan

Reviewed by preLights

Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila

1. Archan Chakraborty
2. Nora G. Peterson
3. Juliet S. King
4. Ryan T. Gross
5. Michelle Mendiola Pla
6. Aatish Thennavan
7. Kevin C. Zhou
8. Sophia DeLuca
9. Nenad Bursac
10. Dawn E. Bowles
11. Matthew J. Wolf
12. Donald T. Fox

Reviewed by preLights

Unclearing Microscopy

1. Ons M’Saad
2. Michael Shribak
3. Joerg Bewersdorf

Reviewed by preLights