Evaluated articles

Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation

1. Courtney M. Clark-Hachtel
2. Jonathan D. Hibshman
3. Tristan De Buysscher
4. Bob Goldstein

Reviewed by preLights

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

1. Björn Klabunde
2. André Wesener
3. Wilhelm Bertrams
4. Isabell Beinborn
5. Nicole Paczia
6. Kristin Surmann
7. Sascha Blankenburg
8. Jochen Wilhelm
9. Javier Serrania
10. Kèvin Knoops
11. Eslam M. Elsayed
12. Katrin Laakmann
13. Anna Lena Jung
14. Andreas Kirschbaum
15. Sven Hammerschmidt
16. Belal Alshaar
17. Nicolas Gisch
18. Mobarak Abu Mraheil
19. Anke Becker
20. Uwe Völker
21. Evelyn Vollmeister
22. Birke J. Benedikter
23. Bernd Schmeck

Reviewed by preLights

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

1. Hayden T. Pacl
2. Krishna C. Chinta
3. Vineel P. Reddy
4. Sajid Nadeem
5. Ritesh R. Sevalkar
6. Kierveshan Nargan
7. Kapongo Lumamba
8. Threnesan Naidoo
9. Joel N. Glasgow
10. Anupam Agarwal
11. Adrie J. C. Steyn

Reviewed by preLights

Mentoring practices predictive of doctoral student outcomes in a biological sciences cohort

1. Reena Debray
2. Emily A. Dewald-Wang
3. Katherine K. Ennis

Reviewed by preLights

PUFFFIN: A novel, ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods

1. Tamina Lebek
2. Mattias Malaguti
3. Alistair Elfick
4. Sally Lowell

Reviewed by Review Commons, preLights

Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions

1. Mrityunjoy Kar
2. Laura T. Vogel
3. Gaurav Chauhan
4. Hannes Ausserwöger
5. Timothy J. Welsh
6. Anjana R. Kamath
7. Tuomas P. J. Knowles
8. Anthony A. Hyman
9. Claus A. M. Seidel
10. Rohit V. Pappu

Reviewed by preLights

The genome of the colonial hydroid Hydractinia reveals that their stem cells use a toolkit of evolutionarily shared genes with all animals

1. Christine E. Schnitzler
2. E. Sally Chang
3. Justin Waletich
4. Gonzalo Quiroga-Artigas
5. Wai Yee Wong
6. Anh-Dao Nguyen
7. Sofia N. Barreira
8. Liam B. Doonan
9. Paul Gonzalez
10. Sergey Koren
11. James M. Gahan
12. Steven M. Sanders
13. Brian Bradshaw
14. Timothy Q. DuBuc
15. Febrimarsa
16. Danielle de Jong
17. Eric P. Nawrocki
18. Alexandra Larson
19. Samantha Klasfeld
20. Sebastian G. Gornik
21. R. Travis Moreland
22. Tyra G. Wolfsberg
23. Adam M. Phillippy
24. James C. Mullikin
25. Oleg Simakov
26. Paulyn Cartwright
27. Matthew Nicotra
28. Uri Frank
29. Andreas D. Baxevanis

Reviewed by preLights

TLR2 regulates hair follicle cycle and regeneration via BMP signaling

1. Luyang Xiong
2. Irina Zhevlakova
3. Xiaoxia Z West
4. Detao Gao
5. Rakhilya Murtazina
6. Anthony Horak
7. J Mark Brown
8. Iuliia Molokotina
9. Eugene A Podrez
10. Tatiana V Byzova

• Curated by eLife

  eLife assessment

  Toll like receptor 2 (TLR2) signaling has traditionally been viewed a surface protein that induces innate immune responses and improves acquired immunity. Here, the authors suggest a different role for TLR2 in the hair cycle. By using a Cre reporter that is largely, but not solely active in hair follicle stem cells, the authors conditionally delete Tlr2 in mice and report that BMP signaling is sustained and hair cycle entry is delayed. Delving further, the authors identify CEP (2-ω-carboxyethyl pyrrole) as an endogenous ligand of TLR2 in hair follicle stem cell regulation. Although a role for TLR2 signaling in hair follicle stem cells is potentially novel and important, the reviewers remain in consensus that evidence presented in two significant areas continues to be incomplete: 1) where TLR2 and CEP are expressed and how specific is their expression to the hair follicle stem cells; 2) whether as the authors suggest, TLR2 functions by regulating BMP signaling in the stem cell niche of the hair follicle.

Reviewed by eLife, preLights

Optical Control of G-Actin with a Photoswitchable Latrunculin

1. Nynke A. Vepřek
2. Madeline H. Cooper
3. Laura Laprell
4. Emily Jie-Ning Yang
5. Sander Folkerts
6. Ruiyang Bao
7. Malgorzata Boczkowska
8. Nicholas J. Palmer
9. Roberto Dominguez
10. Thomas G. Oertner
11. Liza A. Pon
12. J. Bradley Zuchero
13. Dirk H. Trauner

Reviewed by preLights

Hypoxia blunts angiogenic signaling and upregulates the antioxidant system in elephant seal endothelial cells

1. Kaitlin N Allen
2. Julia María Torres-Velarde
3. Juan Manuel Vazquez
4. Diana D Moreno-Santillan
5. Peter H Sudmant
6. José Pablo Vázquez-Medina

Reviewed by preLights

Mechano-dependent sorbitol accumulation supports biomolecular condensate

1. Stephanie Torrino
2. William M. Oldham
3. Andrés R. Tejedor
4. Ignacio S. Burgos
5. Lara Nasr
6. Nesrine Rachedi
7. Kéren Fraissard
8. Caroline Chauvet
9. Chaima Sbai
10. Brendan P. O’Hara
11. Sophie Abélanet
12. Frederic Brau
13. Cyril Favard
14. Stephan Clavel
15. Rosana Collepardo-Guevara
16. Jorge R. Espinosa
17. Issam Ben-Sahra
18. Thomas Bertero

Reviewed by preLights

CRISPR-dependent Base Editing Screens Identify Separation of Function Mutants of RADX with Altered RAD51 Regulatory Activity

1. Madison B. Adolph
2. Atharv S. Garje
3. Swati Balakrishnan
4. Florian Morati
5. Mauro Modesti
6. Walter J. Chazin
7. David Cortez

Reviewed by preLights

Proteasome condensate formation is driven by multivalent interactions with shuttle factors and K48-linked ubiquitin chains

1. Kenrick A. Waite
2. Gabrielle Vontz
3. Stella Y. Lee
4. Jeroen Roelofs

Reviewed by preLights

A Phosphoproteomics Data Resource for Systems-level Modeling of Kinase Signaling Networks

1. Song Feng
2. James A. Sanford
3. Thomas Weber
4. Chelsea M. Hutchinson-Bunch
5. Panshak P. Dakup
6. Vanessa L. Paurus
7. Kwame Attah
8. Herbert M. Sauro
9. Wei-Jun Qian
10. H. Steven Wiley

Reviewed by preLights

H ₂ O ₂ sulfenylates CHE linking local infection to establishment of systemic acquired resistance

1. Lijun Cao
2. Heejin Yoo
3. Tianyuan Chen
4. Musoki Mwimba
5. Xing Zhang
6. Xinnian Dong

Reviewed by preLights

Coordinated regulation of photosynthesis and translation via NIK1/RPL10/LIMYB signaling module in response to biotic and abiotic stresses

1. Ruan M. Teixeira
2. Marco Aurélio Ferreira
3. Otávio J.B. Brustolini
4. Thainá F.F. Saia
5. James Jean-Baptiste
6. Samera S. Breves
7. Igor N. Soares
8. Nathalia G.A. Ribeiro
9. Christiane E. M. Duarte
10. Lucas L. Lima
11. Leandro Licursi Oliveira
12. Humberto J.O. Ramos
13. Pedro A.B. Reis
14. Elizabeth P. B. Fontes

Reviewed by preLights

Similarity metric learning on perturbational datasets improves functional identification of perturbations

1. Ian Smith
2. Petr Smirnov
3. Benjamin Haibe-Kains

Reviewed by preLights

PYCR1 Levels Track with Premature and Chronological Skin Aging

1. Kortessa Sotiropoulou
2. Saniye Yumlu
3. Tomoko Hirano
4. Michael Maier
5. Abigail Loh
6. Peh Fern Ong
7. Onn Siong Yim
8. Chunping Liu
9. Emmanuel Vial
10. Umut Altunoğlu
11. Sheela Nampoothiri
12. Deepthi de Silva
13. Björn Fischer-Zirnsak
14. Hülya Kayserili
15. Poh San Lai
16. Oliver Dreesen
17. Kenji Kabashima
18. Uwe Kornak
19. Nathalie Escande-Beillard
20. Bruno Reversade

• Curated by eLife

  eLife assessment

  This manuscript uses genetic mouse modeling to delve deeper into a rare human disease of aging. The targeted approaches employed lend greater pathophysiologic insight and makes this paper valuable to the field art large. Additionally, the approaches used are rigorous and solid in supporting their conclusions. Some minor weaknesses were noted along with suggestions to add greater clarity.

Reviewed by eLife, preLights

The landscape of biomedical research

1. Rita González-Márquez
2. Luca Schmidt
3. Benjamin M. Schmidt
4. Philipp Berens
5. Dmitry Kobak

Reviewed by preLights

Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

1. Astrid Hendriks
2. Priscilla F. Kerkman
3. Meri R.J. Varkila
4. Jelle L.G. Haitsma-Mulier
5. Sara Ali
6. Thijs ten Doesschate
7. Thomas W. van der Vaart
8. Carla J.C. de Haas
9. Piet C. Aerts
10. Olaf L. Cremer
11. Marc J.M. Bonten
12. Victor Nizet
13. George Y. Liu
14. Jeroen D.C. Codée
15. Suzan H.M. Rooijakkers
16. Jos A.G. van Strijp
17. Nina M. van Sorge

Reviewed by preLights