Evaluated articles

Lens placode modulates extracellular matrix formation during early eye development

1. Cecília G. De Magalhães
2. Ales Cvekl
3. Ruy G. Jaeger
4. C.Y. Irene Yan

Reviewed by preLights

DNA methylation enables recurrent endogenization of giant viruses in an animal relative

1. Luke A. Sarre
2. Iana V. Kim
3. Vladimir Ovchinnikov
4. Marine Olivetta
5. Hiroshi Suga
6. Omaya Dudin
7. Arnau Sebé-Pedrós
8. Alex de Mendoza

Reviewed by preLights

Learning a conserved mechanism for early neuroectoderm morphogenesis

1. Matthew Lefebvre
2. Jonathan Colen
3. Nikolas Claussen
4. Fridtjof Brauns
5. Marion Raich
6. Noah Mitchell
7. Michel Fruchart
8. Vincenzo Vitelli
9. Sebastian J Streichan

Reviewed by preLights

Experience-dependent plasticity of a highly specific olfactory circuit in Drosophila melanogaster

1. Benjamin Fabian
2. Veit Grabe
3. Rolf G. Beutel
4. Bill S. Hansson
5. Silke Sachse

Reviewed by preLights

A direct experimental test of Ohno’s hypothesis

1. Ljiljana Mihajlovic
2. Bharat Ravi Iyengar
3. Florian Baier
4. Içvara Barbier
5. Justyna Iwaszkiewicz
6. Vincent Zoete
7. Andreas Wagner
8. Yolanda Schaerli

• Curated by eLife

  eLife Assessment

  This fundamental study uses a creative experimental system to directly test Ohno's hypothesis, which describes how and why new genes might evolve by duplication of existing ones. In agreement with existing criticism of Ohno's original idea, the authors present compelling evidence that having two gene copies does not speed up the evolution of a new function as posited by Ohno, but instead leads to the rapid inactivation of one of the copies through the accumulation of mostly deleterious mutations. These findings will be of broad interest to evolutionary biologists and geneticists.

Reviewed by eLife, preLights

Characterization of Identified Dopaminergic Neurons in the Mouse Forebrain and Midbrain

1. Maggy Yu Hei Lau
2. Sana Gadiwalla
3. Susan Jones
4. Elisa Galliano

Reviewed by preLights

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

1. Jayne Aiken
2. Erika L. F. Holzbaur

Reviewed by preLights

Inference of drug off-target effects on cellular signaling using interactome-based deep learning

1. Nikolaos Meimetis
2. Douglas A. Lauffenburger
3. Avlant Nilsson

Reviewed by preLights

Hibernating ribosomes tether to mitochondria as an adaptive response to cellular stress during glucose depletion

1. Olivier Gemin
2. Maciej Gluc
3. Michael Purdy
4. Higor Rosa
5. Moritz Niemann
6. Yelena Peskova
7. Simone Mattei
8. Ahmad Jomaa

Reviewed by preLights

Structured RhoGEF recruitment drives myosin II organization on large exocytotic vesicles

1. Kumari Kamalesh
2. Dagan Segal
3. Ori Avinoam
4. Eyal D. Schejter
5. Ben-Zion Shilo

Reviewed by preLights

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

1. Hasan Mamar
2. Roberta Fajka-Boja
3. Mónika Mórocz
4. Eva Pinto Jurado
5. Siham Zentout
6. Alexandra Mihuț
7. Anna Georgina Kopasz
8. Mihály Mérey
9. Rebecca Smith
10. Lajos Haracska
11. Sébastien Huet
12. Gyula Timinszky

Reviewed by preLights

Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

1. Jeanette A.I. Johnson
2. Genevieve L. Stein-O’Brien
3. Max Booth
4. Randy Heiland
5. Furkan Kurtoglu
6. Daniel R. Bergman
7. Elmar Bucher
8. Atul Deshpande
9. André Forjaz
10. Michael Getz
11. Ines Godet
12. Melissa Lyman
13. John Metzcar
14. Jacob Mitchell
15. Andrew Raddatz
16. Heber Rocha
17. Jacobo Solorzano
18. Aneequa Sundus
19. Yafei Wang
20. Danielle Gilkes
21. Luciane T. Kagohara
22. Ashley L. Kiemen
23. Elizabeth D. Thompson
24. Denis Wirtz
25. Pei-Hsun Wu
26. Neeha Zaidi
27. Lei Zheng
28. Jacquelyn W. Zimmerman
29. Elizabeth M. Jaffee
30. Young Hwan Chang
31. Lisa M. Coussens
32. Joe W. Gray
33. Laura M. Heiser
34. Elana J. Fertig
35. Paul Macklin

Reviewed by preLights

Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease

1. Juan Carlos Bórquez
2. Francisco Díaz-Castro
3. Francisco Pino-de La Fuente
4. Karla Espinoza
5. Ana María Figueroa
6. Inma Martínez-Ruíz
7. Vanessa Hernández
8. Iliana López-Soldado
9. Raúl Ventura
10. Alejandra Espinosa
11. Víctor Cortés
12. María Isabel Hernández-Alvarez
13. Rodrigo Troncoso

Reviewed by preLights

A Window into Mammalian Basement Membrane Development: Insights from the mTurq2-Col4a1 Mouse Model

1. Rebecca A. Jones
2. Brandon Trejo
3. Parijat Sil
4. Katherine A. Little
5. H. Amalia Pasolli
6. Bradley Joyce
7. Eszter Posfai
8. Danelle Devenport

Reviewed by preLights

LincRNAs enable germ cells differentiation by promoting PUF proteins condensation

1. Roni Falk
2. Noa Gilad
3. Hanna Achache
4. Yisrael Rappaport
5. Reut Shabtai
6. Hasan Ishtayeh
7. Laura Wolovelsky
8. Yonatan B. Tzur

Reviewed by preLights

Competition and synergy of Arp2/3 and formins in nucleating actin waves

1. Xiang Le Chua
2. Chee San Tong
3. Maohan Su
4. X.J. Xǔ
5. Shengping Xiao
6. Xudong Wu
7. Min Wu

Reviewed by preLights

Metabolomic profiling reveals effects of marein on energy metabolism in HepG2 cells

1. Baoping Jiang
2. Liang Le
3. Keping Hu
4. Lijia Xu
5. Peigen Xiao

Reviewed by preLights

Short disordered termini and proline-rich domain are major regulators of UBQLN1/2/4 phase separation

1. Thuy P. Dao
2. Anitha Rajendran
3. Sarasi K.K. Galagedera
4. William Haws
5. Carlos A. Castañeda

Reviewed by preLights

Parallel gene size and isoform expansion of ancient neuronal genes

1. Matthew J. McCoy
2. Andrew Z. Fire

Reviewed by preLights

Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation

1. Courtney M. Clark-Hachtel
2. Jonathan D. Hibshman
3. Tristan De Buysscher
4. Bob Goldstein

Reviewed by preLights