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  1. Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2

    This article has 18 authors:
    1. Chrystian Junqueira Alves
    2. Theodore Hannah
    3. Sita Sadia
    4. Christy Kolsteeg
    5. Angela Dixon
    6. Robert J. Wiener
    7. Ha Nguyen
    8. Murray J. Tipping
    9. Júlia Silva Ladeira
    10. Paula Fernandes da Costa Franklin
    11. Nathália de Paula Dutra de Nigro
    12. Rodrigo Alves Dias
    13. Priscila V. Zabala Capriles
    14. José P. Rodrigues Furtado de Mendonça
    15. Paul Slesinger
    16. Kevin Costa
    17. Hongyan Zou
    18. Roland H. Friedel

    Reviewed by preLights

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  2. Decoding the Molecular Language of Proteins with Evola

    This article has 13 authors:
    1. Xibin Zhou
    2. Chenchen Han
    3. Yingqi Zhang
    4. Jin Su
    5. Kai Zhuang
    6. Shiyu Jiang
    7. Zichen Yuan
    8. Wei Zheng
    9. Fengyuan Dai
    10. Yuyang Zhou
    11. Yuyang Tao
    12. Dan Wu
    13. Fajie Yuan

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  3. Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche

    This article has 17 authors:
    1. Claire Masson
    2. Cyril Scandola
    3. Jean-Yves Rinckel
    4. Fabienne Proamer
    5. Emily Janus-Bell
    6. Fareeha Batool
    7. Naël Osmani
    8. Jacky G Goetz
    9. Léa Mallo
    10. Catherine Léon
    11. Alicia Bornert
    12. Renaud Poincloux
    13. Olivier Destaing
    14. Alma Mansson
    15. Hong Qian
    16. Maxime Lehmann
    17. Anita Eckly
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors provide a thorough investigation of the interaction of megakaryocytes (MK) with their associated extracellular matrix (ECM) during maturation; they provide evidence that the existence of a dense cage-like pericellular structure containing laminin γ1 and α4 and collagen IV is key to fixing the perisinusoidal localization of MK and preventing their premature intravasation. Adhesion of MK to this ECM cage is dependent on integrin beta1 and beta3 expressed by MK. This strong and solid conclusion is based on the use of state-of-the art techniques such as the use of primary murine bone marrow MK cultures, mice lacking ECM receptors, namely integrin beta1 and beta3 null mice, as well as high-resolution 2D and 3D imaging. The study provides valuable insight into the role of cell-matrix interactions in MK maturation and provides an interesting model with practical implications for the fields of hemostasis and thrombosis.

    Reviewed by preLights, eLife

    This article has 6 evaluationsAppears in 2 listsLatest version Latest activity
  4. Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

    This article has 30 authors:
    1. Kevin Wilhelmsen
    2. Aditi Deshpande
    3. Sarah Tronnes
    4. Maitriyee Mahanta
    5. Matthew Banicki
    6. Mary Cochran
    7. Samantha Cowdin
    8. Kristen Fortney
    9. George Hartman
    10. Robert Hughes
    11. Rusty Montgomery
    12. Claudia Portillo
    13. Paul Rubin
    14. Yan Wang
    15. Shijun Yan
    16. Barry A Morgan
    17. Assem Duisembekova
    18. Romane Riou
    19. Michael Marleaux
    20. Inga V. Hochheiser
    21. Hannes Buthmann
    22. Dominic Ferber
    23. Wei Wang
    24. Melanie Cranston
    25. Chloe M. McKee
    26. Thea Mawhinney
    27. Emma McKay
    28. Bénédicte F. Py
    29. Matthias Geyer
    30. Rebecca C. Coll

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  5. Mechanical stresses govern myoblast fusion and myotube growth

    This article has 9 authors:
    1. Yoann Le Toquin
    2. Sushil Dubey
    3. Aleksandra Ardaševa
    4. Lakshmi Balasubramaniam
    5. Emilie Delaune
    6. Valérie Morin
    7. Amin Doostmohammadi
    8. Christophe Marcelle
    9. Benoît Ladoux

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  6. Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models

    This article has 15 authors:
    1. Nalini R. Rao
    2. Olivia DeGulis
    3. Toshihiro Nomura
    4. SeungEun Lee
    5. Timothy J. Hark
    6. Justin C. Dynes
    7. Emily X. Dexter
    8. Maciej Dulewicz
    9. Junyue Ge
    10. Arun Upadhyay
    11. Eugenio F. Fornasiero
    12. Robert Vassar
    13. Jörg Hanrieder
    14. Anis Contractor
    15. Jeffrey N. Savas

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