Evaluated articles

Deletion of PIEZO1 in adult cardiomyocytes accelerates cardiac aging and causes premature death

1. Ze-Yan Yu
2. Yang Guo
3. Scott Kesteven
4. Delfine Cheng
5. Hanzhou Lei
6. Jianxin Wu
7. Evelyn Nadar
8. Peter Macdonald
9. Munira Xaymardan
10. Charles D. Cox
11. Michael P. Feneley
12. Boris Martinac

Reviewed by preLights

Decoding the Molecular Language of Proteins with Evola

1. Xibin Zhou
2. Chenchen Han
3. Yingqi Zhang
4. Jin Su
5. Kai Zhuang
6. Shiyu Jiang
7. Zichen Yuan
8. Wei Zheng
9. Fengyuan Dai
10. Yuyang Zhou
11. Yuyang Tao
12. Dan Wu
13. Fajie Yuan

Reviewed by preLights

Conservation and divergence of regulatory architecture in nitrate-responsive plant gene circuits

1. C Bian
2. GS Demirer
3. MT Oz
4. Y Cai
5. SS Witham
6. GA Mason
7. Z Di
8. F Deligne
9. P Zhang
10. R Shen
11. A Gaudinier
12. SM Brady
13. NJ Patron

Reviewed by preLights

Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

1. Friederike M.C. Benning
2. Tristan A. Bell
3. Tran H. Nguyen
4. Della Syau
5. Louise B. Connell
6. Yi-Ting Liao
7. Matthew Keating
8. Margaret Coughlin
9. Anja E.H. Nordstrom
10. Maria Ericsson
11. Corrie J.B. daCosta
12. Luke H Chao

Reviewed by preLights

A zebrafish circuit for behavioral credit assignment

1. Emanuele Paoli
2. Virginia Palieri
3. Amey Shenoy
4. Ruben Portugues

Reviewed by preLights

Scaly-Tail Organ Enhances Static Stability during Pel’s Scaly-tailed Flying Squirrels’ Arboreal Locomotion

1. Andrew K. Schulz
2. Mrudul Chellapurath
3. Pranav C. Khandelwal
4. SeyedReza Rezaei
5. Stefan Merker
6. Ardian Jusufi

Reviewed by preLights

Tidyplots empowers life scientists with easy code-based data visualization

1. Jan Broder Engler

Reviewed by preLights

Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche

1. Claire Masson
2. Cyril Scandola
3. Jean-Yves Rinckel
4. Fabienne Proamer
5. Emily Janus-Bell
6. Fareeha Batool
7. Naël Osmani
8. Jacky G Goetz
9. Léa Mallo
10. Catherine Léon
11. Alicia Bornert
12. Renaud Poincloux
13. Olivier Destaing
14. Alma Mansson
15. Hong Qian
16. Maxime Lehmann
17. Anita Eckly

• Curated by eLife

  eLife Assessment

  The authors provide a thorough investigation of the interaction of megakaryocytes (MK) with their associated extracellular matrix (ECM) during maturation; they provide evidence that the existence of a dense cage-like pericellular structure containing laminin γ1 and α4 and collagen IV is key to fixing the perisinusoidal localization of MK and preventing their premature intravasation. Adhesion of MK to this ECM cage is dependent on integrin beta1 and beta3 expressed by MK. This strong and solid conclusion is based on the use of state-of-the art techniques such as the use of primary murine bone marrow MK cultures, mice lacking ECM receptors, namely integrin beta1 and beta3 null mice, as well as high-resolution 2D and 3D imaging. The study provides valuable insight into the role of cell-matrix interactions in MK maturation and provides an interesting model with practical implications for the fields of hemostasis and thrombosis.

Reviewed by preLights, eLife

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

1. Kevin Wilhelmsen
2. Aditi Deshpande
3. Sarah Tronnes
4. Maitriyee Mahanta
5. Matthew Banicki
6. Mary Cochran
7. Samantha Cowdin
8. Kristen Fortney
9. George Hartman
10. Robert Hughes
11. Rusty Montgomery
12. Claudia Portillo
13. Paul Rubin
14. Yan Wang
15. Shijun Yan
16. Barry A Morgan
17. Assem Duisembekova
18. Romane Riou
19. Michael Marleaux
20. Inga V. Hochheiser
21. Hannes Buthmann
22. Dominic Ferber
23. Wei Wang
24. Melanie Cranston
25. Chloe M. McKee
26. Thea Mawhinney
27. Emma McKay
28. Bénédicte F. Py
29. Matthias Geyer
30. Rebecca C. Coll

Reviewed by preLights

Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons

1. Klaudia Strucinska
2. Parker Kneis
3. Travis Pennington
4. Katarzyna Cizio
5. Patrycja Szybowska
6. Abigail Morgan
7. Joshua Weertman
8. Tommy L Lewis

Reviewed by preLights

Visually-guided compensation of deafening-induced song deterioration

1. M Rolland
2. A Zai
3. RHR Hahnloser
4. C Del Negro
5. N Giret

Reviewed by preLights

Mechanical stresses govern myoblast fusion and myotube growth

1. Yoann Le Toquin
2. Sushil Dubey
3. Aleksandra Ardaševa
4. Lakshmi Balasubramaniam
5. Emilie Delaune
6. Valérie Morin
7. Amin Doostmohammadi
8. Christophe Marcelle
9. Benoît Ladoux

Reviewed by preLights

IMMClock reveals immune aging and T cell function at single-cell resolution

1. Yael Gurevich Schmidt
2. Di Wu
3. Sanna Madan
4. Sanju Sinha
5. Sahil Sahni
6. Vishaka Gopalan
7. Binbin Wang
8. Saugato Rahman Dhruba
9. Alejandro A. Schäffer
10. Nan-ping Weng
11. Nicholas P. Restifo
12. Kun Wang
13. Eytan Ruppin

Reviewed by preLights

Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models

1. Nalini R. Rao
2. Olivia DeGulis
3. Toshihiro Nomura
4. SeungEun Lee
5. Timothy J. Hark
6. Justin C. Dynes
7. Emily X. Dexter
8. Maciej Dulewicz
9. Junyue Ge
10. Arun Upadhyay
11. Eugenio F. Fornasiero
12. Robert Vassar
13. Jörg Hanrieder
14. Anis Contractor
15. Jeffrey N. Savas

Reviewed by preLights

Thermal preconditioning modulates coral physiology and heat tolerance: A multi-species perspective

1. Erik F. Ferrara
2. Anna Roik
3. Franziska Wöhrmann-Zipf
4. Maren Ziegler

Reviewed by preLights

Adenine DNA methylation associated to transcription is widespread across eukaryotes

1. Pedro Romero Charria
2. Cristina Navarrete
3. Vladimir Ovchinnikov
4. Luke A Sarre
5. Victoria Shabardina
6. Elena Casacuberta
7. David Lara-Astiaso
8. Arnau Sebé-Pedrós
9. Alex de Mendoza

Reviewed by preLights

Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo

1. Daniel M. Snell
2. Wazeer Varsally
3. Aurélien Courtois
4. Sergio Menchero
5. Prabhakaran Munusamy
6. Richelle Rietdijk
7. Obah A. Ojarikre
8. Stephanie Strohbuecker
9. Haskan Kaya
10. Mahesh N. Sangrithi
11. James M.A. Turner

Reviewed by preLights

Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

1. Clotilde C.N. Renaud
2. Carolina Alves Nicolau
3. Clément Maghe
4. Kilian Trillet
5. Jane Jardine
6. Sophie Escot
7. Nicolas David
8. Julie Gavard
9. Nicolas Bidère

Reviewed by preLights

Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes

1. Emily N.P. Prowse
2. Abdullah R. Chaudhary
3. David Sharon
4. Adam G. Hendricks

Reviewed by preLights

Polystyrene nanoplastics promote neurodegeneration by catalyzing TDP43 hyperphosphorylation

1. Winanto
2. Li-Yi Tan
3. Wai Hon Chooi
4. Cheryl Yi-Pin Lee
5. Wan Yun Ho
6. Yong Shan Lim
7. Boon Seng Soh
8. Emma Sanford
9. Chong-Lun Tan
10. Yih-Cherng Liou
11. Cathy Chia-Yu Huang
12. Shuo-Chien Ling
13. Shi-Yan Ng

Reviewed by preLights