Evaluated articles

MAVS is Important for Antiviral Defense Against Influenza A Virus in a Human Respiratory Epithelium Model

1. Maja Hemberg
2. Anne Louise Hansen
3. Jacob Storgaard
4. Julia Blay-Cadanet
5. Alice Pedersen
6. Anne Laugaard Thielke
7. Christian Kanstrup Holm

Reviewed by Review Commons

Unconventional components complement the cryptic kinetochore of the ciliate Tetrahymena thermophila

1. Emine I. Ali
2. Maximilian W. D. Raas
3. Laura E. van Rooijen
4. Paula Sobrevals Alcaraz
5. Harmjan R. Vos
6. Eelco C. Tromer
7. Berend Snel
8. Geert J.P.L. Kops

Reviewed by Review Commons

An actomyosin-mediated mechanical mechanism for brain neural tube elevation

1. Juana De La O
2. Chidera Okeke
3. Gabriel L. Galea
4. Adam C. Martin

Reviewed by Review Commons

Nrf2 promotes thyroid development and hormone synthesis

1. Gillotay Pierre
2. Romitti Mirian
3. Dassy Benjamin
4. Haerlingen Benoit
5. Parakkal Shankar Meghna
6. Faria Fonseca Barbara
7. Ziros G. Panos
8. Pal Singh Sumeet
9. Sykiotis P. Gerasimos
10. Costagliola Sabine

Reviewed by Review Commons

Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells

1. Tohfa Kabir
2. Charlotte A. Connamacher
3. Zara Nadeem
4. Matthew R. Paul
5. Matthew R. Smutny
6. Zoe K. Lawler
7. Annaelle M. Djomo
8. Thomas S. Carroll
9. Leah A. Gates

Reviewed by Review Commons

Five-layer systems analysis of Leishmania stage differentiation reveals an essential role for protein degradation in parasite development

1. Pascale Pescher
2. Thibaut Douché
3. Quentin Giai-Gianetto
4. Karen Druart
5. Julie Kovarova
6. Blaise Li
7. Thomas Cokelaer
8. K Shanmugha Rajan
9. Laura Piel
10. Céline Besse
11. Anne Boland
12. Jean-François Deleuze
13. Mariette Matondo
14. Michael P Barrett
15. Shulamit Michaeli
16. Gerald F Späth

• Curated by eLife

  eLife Assessment

  This important study provides a comprehensive multi-omics characterization of Leishmania donovani stage differentiation, offering insights into the molecular basis of parasite adaptation across host environments. The authors present convincing evidence that stage transitions are not driven by genomic variation but instead rely on coordinated post-transcriptional regulation, including mRNA turnover, translation, and protein degradation. Although experimental validation of these findings and conclusions remains to be completed, the integration of diverse, high-quality datasets establishes a robust resource that will be of broad utility to researchers investigating Leishmania biology and life-cycle progression.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

FuChi: A cell cycle biosensor for investigating cell-cycle kinetics during avian development

1. Zoe R. Sudderick
2. Tiernan Briggs
3. Shirooza Mubarak
4. Melinda Van Kerckvoorde
5. Ana R. Hernandez-Rodriguez
6. Sudeepta K. Panda
7. Jon Riddell;
8. Cameron Batho-Samblas
9. Lorna Taylor
10. Lynn McTeir
11. Dominique Meunier
12. Amy Findlay
13. Flossie Roberts
14. Anna Raper
15. Asako Sakaue-Sawano
16. Atsushi Miyawaki
17. Joe Rainger
18. Jeffrey J. Schoenebeck
19. Cornelis J. Weijer
20. Mike J. McGrew
21. Denis J. Headon
22. Megan G. Davey
23. Richard L. Mort
24. James D. Glover

Reviewed by Review Commons

LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death

1. Andres Goldman
2. Mai Nguyen
3. Joel Lanoix
4. Chongyang Li
5. Ahmed Fahmy
6. Yong Zhong Xu
7. Erwin Schurr
8. Pierre Thibault
9. Michel Desjardins
10. Heidi M. McBride

Reviewed by Review Commons

Single-domain antibody inhibitors target the coiled coil arms of the Bacillus subtilis SMC complex

1. Ophélie J Gosselin
2. Michael Taschner
3. Lea M Huber-Hürlimann
4. Markus A Seeger
5. Stephan Gruber

• Curated by eLife

  eLife Assessment

  This important study introduces an innovative synthetic nanobody approach to probe the function of the bacterial SMC complex. The work is a compelling example of the potential of this approach. The authors generate protein chimeras to provide convincing evidence that their identified nanobodies target the coiled-coil region of the SMC subunit, demonstrating that this region is critical for SMC function in vivo. Overall, the work is significant for the fields of genome organisation, SMC protein biology, synthetic biology, and bacterial cell biology.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Macrophages maintain signaling fidelity in response to ligand mixtures

1. Xiaolu Guo
2. Supriya Sen
3. Julian Gonzalez
4. Alexander Hoffmann

Reviewed by Review Commons

The role of MICOS in organizing mitochondrial cristae in malaria parasites

1. Silvia Tassan-Lugrezin
2. Irina Bregy
3. Judith López Orra
4. Nicholas I Proellochs
5. Geert-Jan van Gemert
6. Rianne Stoter
7. Felix Evers
8. Taco WA Kooij
9. Laura van Niftrik

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into mitochondrial cristae organization in Plasmodium falciparum, particularly in the context of its divergent MICOS composition. The authors present convincing evidence, supported by phenotypic and morphological analyses, that cristae junction maintenance can be uncoupled from de novo cristae formation, reinforcing an emerging model of mitochondrial inner membrane organization. Notably, the absence of Mic10 alongside an enlarged and divergent MICOS complex highlights an intriguing evolutionary adaptation, although further characterization of the complex would strengthen the study's overall significance.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Identifying and targeting abnormal mitochondrial localization associated with psychosis

1. Marzieh Haghighi
2. Donna McPhie
3. Mohammad Rohban
4. Erin Weisbart
5. David J Logan
6. Kyle W Karhohs
7. Suzann M Babb
8. Jessica D Ewald
9. Johan Fredin Haslum
10. Beth A Cimini
11. Shantanu Singh
12. Bruce M Cohen
13. Anne E Carpenter

Reviewed by Review Commons

Four new Duchenne muscular dystrophy mouse models with clinically relevant exon deletions in the human DMD gene

1. Maaike van Putten
2. Margot Linssen
3. Christa Tanganyika-de Winter
4. Conny M. Brouwers
5. Jill W.C. Claassens
6. Nisha Verwey
7. Max Walsh
8. Tiberiu Loredan Stan
9. Annemieke Aartsma-Rus
10. Peter Hohenstein

Reviewed by Review Commons

A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity

1. Anna Demarinis
2. Sara Esmaeili
3. Crystall M. D. Swarbrick
4. Simone Ranno
5. Silvia Pavan
6. Jade K. Forwood
7. Brian P. McSharry
8. Martin Pal
9. Enzo Di Iorio
10. Gualtiero Alvisi

Reviewed by Review Commons

Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz

1. Christina Schmidt
2. Denes Turei
3. Dimitrios Prymidis
4. Macabe Daley
5. Christian Frezza
6. Julio Saez-Rodriguez

Reviewed by Review Commons

Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex

1. Stefano Sellitto
2. Davide Caredio
3. Matteo Bimbati
4. Giovanni Mariutti
5. Martina Cerisoli
6. Lukas Frick
7. Vangelis Bouris
8. Carlos Omar Oueslati Morales
9. Dalila Laura Vena
10. Sandesh Neupane
11. Federico Baroni
12. Kathi Ging
13. Jiang-An Yin
14. Elena De Cecco
15. Andrea Armani
16. Adriano Aguzzi

Reviewed by Review Commons

Nuclear genome profiling of two species of Epidendrum (Orchidaceae): genome size, repeatome and ploidy

1. Miguel A. Alcalá-Gaxiola
2. Gerardo A. Salazar
3. Eric Hágsater
4. Mónica A. Flores-Iniestres
5. Lidia I. Cabrera
6. Aldo I. Aviña-Rivera
7. Pedro Mercado-Ruaro
8. Susana Magallon
9. Carolina Granados Mendoza
10. Aleida Núñez-Ruiz
11. Gloria Soldevila
12. Araxi Urrutia
13. Rubi N. Meza-Lázaro

Reviewed by Review Commons

Metabolite import via SLC33A1 enables ATF6 activation by endoplasmic reticulum stress

1. Ginto George
2. Heather P. Harding
3. Richard Kay
4. David Ron
5. Adriana Ordóñez

Reviewed by Review Commons

C is non-coding genetic variation drives gene expression changes in the E. coli and P. aeruginosa pangenomes

1. Bamu F. Damaris
2. Matylda Zietek
3. Jelena Erdmann
4. Athanasios Typas
5. Susanne Häußler
6. Marco Galardini

Reviewed by Review Commons

The UAP56 mRNA Export Factor is Required for Dendrite and Synapse Pruning via Actin Regulation in Drosophila

1. Samuel Matthew Frommeyer
2. Ulrike Gigengack
3. Sandra Rode
4. Matthew Davies
5. Sebastian Rumpf

Reviewed by Review Commons