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  1. Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

    This article has 8 authors:
    1. Roberta Carloni
    2. Tadhg Devlin
    3. Pin Tong
    4. Christos Spanos
    5. Tanya Auchynnikava
    6. Juri Rappsilber
    7. Keith R Matthews
    8. Robin C Allshire
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work significantly advances our understanding of chromatin organization within regions of repetitive sequences in the parasitic protozoan Trypanosoma brucei. Using cutting edge interdisciplinary tools, the authors provide compelling evidence for two discrete types of repetitive DNA element-associated proteins- one set involved in essential centromere function; and, the other involved in glycoprotein antigenic variation via homologous recombination. Thus, these fundamental findings have implications for this parasite's biology, and for therapeutic targeting in kinetoplastid diseases. This work will be exciting to those in the centromere/mitosis and parasite immunity fields.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

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