Evaluated articles

Inverted Assembly of the Lens Within Ocular Organoids Reveals Alternate Paths to Ocular Morphogenesis

1. Elin Stahl
2. Miguel Angel Delgado-Toscano
3. Ishwariya Saravanan
4. Anastasija Paneva
5. Joachim Wittbrodt
6. Lucie Zilova

• Curated by eLife

  eLife Assessment

  This important study demonstrates that ocular organoids can generate both retina and lens through a non-canonical, "inside-out" morphogenetic route. The work is supported by convincing data, with well-designed experiments combining imaging, molecular analysis, and transcriptomics to establish that lens formation in organoids follows conserved molecular programs despite an alternative morphogenesis. These findings expand our understanding of self-organization and developmental plasticity, and will be of broad interest to researchers working on eye development, organoids, and tissue engineering.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Organization of the yeast Seipin complex reveals differential recruitment of regulatory proteins

1. Yoel A. Klug
2. Pedro Carvalho

Reviewed by Review Commons

Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes

1. Dario D’Asaro
2. Jean-Michel Arbona
3. Vinciane Piveteau
4. Aurèle Piazza
5. Cédric Vaillant
6. Daniel Jost

Reviewed by Review Commons

Transient hypoxia followed by progressive reoxygenation is required for efficient skeletal muscle repair through Rev-ERBα modulation

1. Marie Quétin
2. Audrey Der Vartanian
3. Christelle Dubois
4. Juliette Berthier
5. Marine Ledoux
6. Stéphanie Michineau
7. Bernadette Drayton-Libotte
8. Athanassia Sotiropoulos
9. Frédéric Relaix
10. Marianne Gervais

Reviewed by Review Commons

Reconfiguration of tumor cells with LCOR transcription factor mRNA nanotherapy to enhance immunotherapy efficacy

1. Gabriel Serra-Mir
2. Elena Haro-Martínez
3. Chiara Cannatà
4. José Ángel Palomeque
5. Sandra Blasco-Benito
6. Anna López-Plana
7. María Sanz-Flores
8. Marc Sabartés
9. Cristina Fornaguera
10. Toni Celià-Terrassa

Reviewed by Review Commons

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

1. Roza H. A. Masalmeh
2. John C. Dawson
3. Virginia Alvarez Garcia
4. Morwenna T. Muir
5. Roderick N. Carter
6. Giles E. Hardingham
7. Cameron Davies
8. Rosina Graham
9. Alex von Kriegsheim
10. Jair Marques
11. Chinmayi Pednekar
12. Steven M. Pollard
13. Neil O. Carragher
14. Valerie G. Brunton
15. Margaret C. Frame

Reviewed by Review Commons

Fertilization triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development

1. Ayokunle Araoyinbo
2. Clàudia Salat-Canela
3. Aleksandar Vještica

Reviewed by Review Commons

Systematic identification of Salmonella T6SS effectors uncovers diverse new families and lipid-targeting activities

1. Gianlucca G. Nicastro
2. Stephanie Sibinelli-Sousa
3. Julia T. Hespanhol
4. Thomas W. C. Santos
5. Joseph P. Munoz
6. Rosangela S. Santos
7. Blanca M. Perez-Sepulveda
8. Sayuri Miyamoto
9. L. Aravind
10. Robson F. de Souza
11. Ethel Bayer-Santos

Reviewed by Review Commons

Single-cell analysis of signalling and transcriptional responses to type I interferons

1. Rachel E Rigby
2. Kevin Rue-Albrecht
3. Aleksandr Fedorov
4. David Sims
5. Jan Rehwinkel

Reviewed by Review Commons

Live-cell imaging reveals nutrient-dependent dynamics of ER-mitochondria contact formation via PDZD8

1. Saeko Aoyama-Ishiwatari
2. Koki Nakamura
3. Takahiro Nagao
4. Yusuke Hirabayashi

Reviewed by Review Commons

The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity

1. Shun Kimura
2. Sachiko Sekiya
3. Sawa Yamashiro
4. Tetsutaro Kikuchi
5. Masatoshi Haga
6. Tatsuya Shimizu

Reviewed by Review Commons

Sex-lethal is recruited to chromatin to promote neuronal tRNA synthesis in males through RNA Polymerase III regulation

1. Freya Storer
2. Colin D. McClure
3. Alicia Estacio Gomez
4. Tsz Lam Wong
5. Lucy J. Minkley
6. Tony D. Southall

Reviewed by Review Commons

Inherited CDA-I disease: anemia-associated mutations disrupt CDIN1-Codanin1 complex

1. Martin Stojaspal
2. Tomáš Brom
3. Ivona Nečasová
4. Tomáš Janovič
5. Pavel Veverka
6. Naina Verma
7. Lukáš Uhrík
8. Lenka Hernychova
9. Ctirad Hofr

Reviewed by Review Commons

Deciphering the CD73⁺ Regulatory γδ T Cell ecosystem associated with poor survival in Ovarian cancer

1. Ghita Chabab
2. Henri-Alexandre Michaud
3. Cécile Dejou
4. Laure-Agnès Chépeaux
5. Yaël Glasson
6. Florence Boissière
7. Marion Lenain
8. Anne-Sophie Dumé
9. Pauline Sarrant
10. Gabriel Chemin
11. Pauline Wajda
12. Bertrand Dubois
13. Anna MacManus
14. Pierre-Emmanuel Colombo
15. Michel Fabbro
16. Nathalie Bonnefoy
17. Maeva Chauvin
18. Virginie Lafont

Reviewed by Review Commons

Single-molecule imaging of transcription dynamics, RNA localization and fate in human T cells

1. M Valeria Lattanzio
2. Nikolina Šoštarić
3. Nandhini Kanagasabesan
4. Branka Popović
5. Antonia Bradarić
6. Leyma Wardak
7. Aurélie Guislain
8. Philipp Savakis
9. Evelina Tutucci
10. Monika C Wolkers

Reviewed by Review Commons

Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization

1. Kaho Nishioka
2. Midori Ikezaki
3. Naoyuki Iwahashi
4. Miyu Arakawa
5. Momo Fukushima
6. Noa Mori
7. Mika Mizoguchi
8. Yuko Horiuchi-Tanizaki
9. Megumi Fujino
10. Takami Tomiyama
11. Yoshito Ihara
12. Kenji Uchimura
13. Kazuhiko Ino
14. Kazuchika Nishitsuji

Reviewed by Review Commons

A Drosophila screen of schizophrenia-related genes highlights the requirement of neural and glial matrix metalloproteinases for neuronal remodeling

1. Shir Keret
2. Hagar Meltzer
3. Neta Marmor-Kollet
4. Oren Schuldiner

Reviewed by Review Commons

A conserved RNA switch for acetylcholine receptor clustering at neuromuscular junctions in chordates

1. Md. Faruk Hossain
2. Sydney Popsuj
3. Burcu Vitrinel
4. Nicole A. Kaplan
5. Alberto Stolfi
6. Lionel Christiaen
7. Matteo Ruggiu

Reviewed by Review Commons

Roles of the zona pellucida in gamete fusion and of the perivitelline space in blocking polyspermy in mice

1. Yaëlle Dubois
2. Sophie Favier
3. Nathan Martin-Fornier
4. Adrien Freyss
5. Mohyeddine Omrane
6. David Stroebel
7. Eric Perez
8. Sandrine Barbaux
9. Ahmed Ziyyat
10. Nicolas Rodriguez
11. Christine Gourier

Reviewed by Review Commons