Evaluated articles

Srs2/PARI DNA helicase mediates abscission inhibition in response to chromatin bridges in yeast and human cells

1. Monica Dam
2. Nicola Brownlow
3. Audrey Furst
4. Coralie Spiegelhalter
5. Manuel Mendoza

Reviewed by Review Commons

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

1. Nadine Tuechler
2. Mira Lea Burtscher
3. Martin Garrido-Rodriguez
4. Muzamil Majid Khan
5. Dénes Türei
6. Christian Tischer
7. Sarah Kaspar
8. Jennifer Jasmin Schwarz
9. Frank Stein
10. Mandy Rettel
11. Rafael Kramann
12. Mikhail M Savitski
13. Julio Saez-Rodriguez
14. Rainer Pepperkok

Reviewed by Review Commons

Proximity Interactome analyses unveil novel regulators of IRE1α canonical signaling

1. Simon Le Goupil
2. Céline Philippe
3. Hadrien Laprade
4. Mathéo Lode
5. Rachel Boniface
6. Diana Pelizzari-Raymundo
7. Kurt Dejgaard
8. Gregor Jansen
9. Celia Limia
10. Claudio Hetz
11. S. Jalil Mahdizadeh
12. Luc Negroni
13. Marc Aubry
14. Jean-Ehrland Ricci
15. Leif A. Eriksson
16. Eric Chevet

Reviewed by Review Commons

An unconventional interaction interface between the peroxisomal targeting factor Pex5 and Eci1 enables PTS1 independent import

1. Lior Peer
2. Nadav Elad
3. Orly Dym
4. Asa Tirosh
5. Jossef Jacobovitch
6. Shira Albeck
7. Maya Schuldiner
8. Yoav Peleg
9. Einat Zalckvar

Reviewed by Review Commons

Tension-induced suppression of allosteric conformational changes explains coordinated stepping of kinesin-1

1. Tsukasa Makino
2. Ryo Kanada
3. Teppei Mori
4. Ken-ichi Miyazono
5. Yuta Komori
6. Haruaki Yanagisawa
7. Shoji Takada
8. Masaru Tanokura
9. Masahide Kikkawa
10. Michio Tomishige

Reviewed by Review Commons

Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

1. Yamato Niitani
2. Kohei Matsuzaki
3. Erik Jonsson
4. Ronald D Vale
5. Michio Tomishige

• Curated by eLife

  eLife Assessment

  This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and single-molecule assays, the authors demonstrate that the neck linker's conformation differentially modulates nucleotide affinity and detachment rates, establishing an asynchronous chemo-mechanical cycle that prevents simultaneous detachment. Supported by cryo-EM structural data, the work presents an important advance in our understanding of kinesin's hand-over-hand movement.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Hydroxyurea induces ER stress and cytoplasmic protein aggregation

1. Ana Sánchez-Molina
2. Manuel Bernal
3. Joel D. Posligua-García
4. Antonio J. Pérez-Pulido
5. Laura de Cubas
6. Elena Hidalgo
7. Silvia Salas-Pino
8. Rafael R. Daga

Reviewed by Review Commons

Whole genome CRISPR screens identify a LRRK2-regulated pathway for extracellular tau uptake by human neurons

1. Lewis D. Evans
2. Alessio Strano
3. Eleanor Tuck
4. Ashley Campbell
5. James Smith
6. Christy Hung
7. Tiana S. Behr
8. Bernardino Ghetti
9. Benjamin Ryskeldi-Falcon
10. Emre Karakoc
11. Francesco Iorio
12. Alastair Reith
13. Andrew R. Bassett
14. Frederick J. Livesey

Reviewed by Review Commons

Early coordination of cell migration and cardiac fate determination during mammalian gastrulation

1. Shayma Abukar
2. Peter A Embacher
3. Alessandro Ciccarelli
4. Sunita Varsani-Brown
5. Isabel G W North
6. Jamie A Dean
7. James Briscoe
8. Kenzo Ivanovitch

Reviewed by Review Commons

Non-muscle myosin II regulates presynaptic actin assemblies and neuronal mechanobiology in Drosophila

1. Biljana Ermanoska
2. Jonathan Baets
3. Avital A. Rodal

Reviewed by Review Commons

GLE1 dysfunction compromises cellular homeostasis, spatial organization, and peripheral axon branching

1. T Zárybnický
2. S Lindfors
3. S Metso
4. Z Szabo
5. R Valtonen
6. M Tulppo
7. J Magga
8. S Saarimäki
9. S Bläuer
10. I Miinalainen
11. R Kerkelä
12. J Väänänen
13. R Kivelä
14. FP Zhang
15. P Sipilä
16. R Hinttala
17. S Kuure

Reviewed by Review Commons

CCDC32 stabilizes clathrin-coated pits and drives their invagination

1. Ziyan Yang
2. Changsong Yang
3. Zheng Huang
4. Peiliu Xu
5. Yueping Li
6. Lu Han
7. Linyuan Peng
8. Xiangying Wei
9. John E Pak
10. Tatyana Svitkina
11. Sandra L Schmid
12. Zhiming Chen

• Curated by eLife

  eLife Assessment

  The manuscript presents a valuable finding that CCDC32, beyond its reported role in AP2 assembly, follows AP2 to the plasma membrane and regulates clathrin-coated pit assembly and dynamics. The authors further identify an alpha-helical region within CCDC32 that is essential for its interaction with AP2 and its cellular function. While live-cell and ultrastructural imaging data are solid, future biochemical studies will be needed to confirm the proposed CCDC32-AP2 interaction.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

1. Dorival Mendes Rodrigues-Junior
2. Ana Rosa Sáez-Ibáñez
3. Takeshi Terabayashi
4. Nina Daubel
5. Taija Mäkinen
6. Olof Idevall-Hagren
7. Aristidis Moustakas
8. Ingvar Ferby

Reviewed by Review Commons

Bystander activation across a TAD boundary supports a cohesin-dependent hub-model for enhancer function

1. Iain Williamson
2. Katy A. Graham
3. Hannes Becher
4. Robert E. Hill
5. Wendy A. Bickmore
6. Laura A. Lettice

Reviewed by Review Commons

Plasmacytoid dendritic cell sensing of hepatitis E virus is shaped by both viral and host factors

1. Garima Joshi
2. Elodie Décembre
3. Jacques Brocard
4. Claire Montpellier
5. Martin Ferrié
6. Omran Allatif
7. Ann-Kathrin Mehnert
8. Johann Pons
9. Delphine Galiana
10. Viet Loan Dao Thi
11. Nolwenn Jouvenet
12. Laurence Cocquerel
13. Marlène Dreux

Reviewed by Review Commons

Single-molecule tracking reveals the dynamics of Ipl1 recruitment to the kinetochores and spindles in S. cerevisiae

1. Nitesh Kumar Podh
2. Ayan Das
3. Akriti Kumari
4. Kirti Garg
5. Rashmi Yadav
6. Kirti Kashyap
7. Sahil Islam
8. Anupam Gupta
9. Gunjan Mehta

Reviewed by Review Commons

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

1. Pratim Chowdhury
2. Xiaoli Wang
3. Richard I. Han
4. Manga Motrapu
5. Ashley G. Boice
6. Yuya Nakatani
7. Sofia Vargas‐Hernandez
8. Julia F. Love
9. Claude Chew
10. Sandra L. Grimm
11. Dereck Mezquita
12. Frank M. Mason
13. Elisabeth D. Martinez
14. Cristian Coarfa
15. Cheryl L. Walker
16. Anna‐Karin Gustavsson
17. Ruhee Dere

Reviewed by Review Commons

AtVPS13M1 is involved in lipid remodeling in low phosphate and is located at the mitochondria surface in plants

1. Sébastien Leterme
2. Catherine Albrieux
3. Sabine Brugière
4. Yohann Couté
5. Julien Dellinger
6. Benjamin Gillet
7. Sandrine Hughes
8. Julie Castet
9. Amélie Bernard
10. David Scheuring
11. Marion Schilling
12. Juliette Jouhet
13. Morgane Michaud

Reviewed by Review Commons

A protein kinase A-regulated centrosomal actin pool sets the threshold for T cell polarization

1. Morgane Simao
2. Fabienne Régnier
3. Clotilde Randriamampita

Reviewed by Review Commons

The chromatin remodeler DEK promotes proliferation of mammary epithelium and is associated with H3K27me3 epigenetic modifications

1. Megan Johnstone
2. Ashley Leck
3. Taylor Lange
4. Katherine Wilcher
5. Miranda S. Shephard
6. Aditi Paranjpe
7. Sophia Schutte
8. Susanne Wells
9. Ferdinand Kappes
10. Nathan Salomonis
11. Lisa M. Privette Vinnedge

Reviewed by Review Commons