Evaluated articles

A list by Review Commons

Articles that have been evaluated by Review Commons.

1381 articlesLast updated

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  1. A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei

    1. Mohammad Zeeshan
    2. Igor Blatov
    3. Ryuji Yanase
    4. David JP Ferguson
    5. Sarah L Pashley
    6. Zeinab Chahine
    7. Yoshiki Yamaryo-Botté
    8. Akancha Mishra
    9. Baptiste Marche
    10. Suhani Bhanvadia
    11. Molly Hair
    12. Sagar Batra
    13. Robert Markus
    14. Declan Brady
    15. Andrew R Bottrill
    16. Sue Vaughan
    17. Cyrille Y Botté
    18. Karine G Le Roch
    19. Anthony A Holder
    20. Eelco Tromer
    21. Rita Tewari

    • Curated by eLife

      eLife Assessment

      In Plasmodium male gametocytes, rapid nuclear division occurs with an intact nuclear envelope, requiring precise coordination between nuclear and cytoplasmic events to ensure proper packaging of each nucleus into a developing gamete. This valuable study characterizes two proteins involved in the formation of Plasmodium berghei male gametes. By integrating live-cell imaging, ultrastructural expansion microscopy, and proteomics, this study convincingly identifies SUN1 and its interaction partner ALLAN as crucial nuclear envelope components in male gametogenesis. A role for SUN1 in membrane dynamics and lipid metabolism is less well supported. The results are of interest for general cell biologists working on unusual mitosis pathways.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    8 evaluationsAppears in 2 listsLatest version Latest activity

  2. The influence of the pre-membrane and envelope proteins on structure, pathogenicity and tropism of tick-borne encephalitis virus

    1. Ebba Rosendal
    2. Kyrylo Bisikalo
    3. Stefanie M.A. Willekens
    4. Marie Lindgren
    5. Jiří Holoubek
    6. Pavel Svoboda
    7. Amanda Lappalainen
    8. Ebba Könighofer
    9. Ekaterina Mirgorodskaya
    10. Rickard Nordén
    11. Federico Morini
    12. William Rosenbaum
    13. Daniel Růžek
    14. Ulf Ahlgren
    15. Maria Anastasina
    16. Andres Merits
    17. Sarah J Butcher
    18. Emma Nilsson
    19. Anna K Överby

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

    1. Liuqun Zhao
    2. Tanel Punga
    3. Suparna Sanyal

    • Curated by eLife

      eLife Assessment

      This important study investigates the molecular mechanisms by which the p53 isoforms Δ133p53α and Δ160p53α exert dominant-negative effects on full-length p53 (FLp53). Through a combination of chromatin immunoprecipitation, transcriptional reporter assays, subcellular localization analyses, and protein aggregation experiments, the authors provide solid evidence that these N-terminally truncated isoforms promote co-aggregation with FLp53, disrupting its transcriptional activity and cellular distribution. The revised manuscript successfully addresses prior reviewer concerns, and the findings are well supported by the experimental data.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    8 evaluationsAppears in 2 listsLatest version Latest activity

  6. Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

    1. Ryo Egawa
    2. Kota Hiraga
    3. Ryosuke Matsui
    4. Dai Watanabe
    5. Hiroshi Kuba

    • Curated by eLife

      eLife Assessment

      This important study uses the delay line axon model in the chick brainstem auditory circuit to examine the interactions between oligodendrocytes and axons in the formation of internodal distances. This is a significant and actively studied topic, and the authors have used this preparation to support the hypothesis that regional heterogeneity in oligodendrocytes underlies the observed variation in internodal length. In a solid series of experiments, the authors have used enhanced tetanus neurotoxin light chains, a genetically encoded silencing tool, to inhibit vesicular release from axons and support the hypothesis that regional heterogeneity among oligodendrocytes may underlie the biased nodal spacing pattern in the sound localization circuit.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    17 evaluationsAppears in 2 listsLatest version Latest activity

  12. Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription

    1. Chaïma Azouzi
    2. Katrin Schwank
    3. Sophie Queille
    4. Marta Kwapisz
    5. Marion Aguirrebengoa
    6. Anthony Henras
    7. Simon Lebaron
    8. Herbert Tschochner
    9. Annick Lesne
    10. Frédéric Beckouët
    11. Olivier Gadal
    12. Christophe Dez

    • Curated by eLife

      eLife Assessment

      This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present convincing evidence that demonstrates the existence of premature termination in Pol I transcription. Overall, the characterization of this RNA pol I offers important insights into the regulation of ribosomal RNA transcription and its potential application in cancer pharmacology.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    14 evaluationsAppears in 2 listsLatest version Latest activity

  13. Modularity of the segmentation clock and morphogenesis

    1. James E Hammond
    2. Ruth E Baker
    3. Berta Verd

    • Curated by eLife

      eLife Assessment

      This valuable manuscript uses mathematical modeling to address the synchrony of the vertebrate segmentation clock with the developmental processes. The authors use convincing arguments to support the idea that this would allow the evolution of flexible body plans and a variable number of segments. This manuscript could be of interest to developmental biologists and systems biologists.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    9 evaluationsAppears in 2 listsLatest version Latest activity

  15. Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patients

    1. Roni Ben-Ami
    2. Netanel Loyfer
    3. Eden Cohen
    4. Gavriel Fialkoff
    5. Israa Sharkia
    6. Naama Bogot
    7. Danit Kochan
    8. George Kalak
    9. Amir Jarjoui
    10. Chen Chen-Shuali
    11. Hava Azulai
    12. Hezi Barhoum
    13. Nissim Arish
    14. Moshe M Greenberger
    15. David Vellema
    16. Ramzi Kurd
    17. Eli Ben Chetrit
    18. Davina Bohm
    19. Talya Wolak
    20. Ahmad Quteineh
    21. Gordon Cann
    22. Benjamin Glaser
    23. Nir Friedman
    24. Tommy Kaplan
    25. Ruth Shemer
    26. Ariel Rokach
    27. Yuval Dor

    Reviewed by Review Commons, Rapid Reviews Infectious Diseases

    7 evaluationsAppears in 2 listsLatest version Latest activity

  17. Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

    1. Nadine Tuechler
    2. Mira Lea Burtscher
    3. Martin Garrido-Rodriguez
    4. Muzamil Majid Khan
    5. Dénes Türei
    6. Christian Tischer
    7. Sarah Kaspar
    8. Jennifer Jasmin Schwarz
    9. Frank Stein
    10. Mandy Rettel
    11. Rafael Kramann
    12. Mikhail M Savitski
    13. Julio Saez-Rodriguez
    14. Rainer Pepperkok

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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