Evaluated articles

An in vitro human vessel model to study Neisseria meningitidis colonization and vascular damages

1. Léa Pinon
2. Melanie Chabaud
3. Pierre Nivoit
4. Jerome Wong Ng
5. Tri-Tho Nguyen
6. Vanessa Paul
7. Charlotte Bouquerel
8. Sylvie Goussard
9. Pauline Smilovici
10. Emmanuel Frachon
11. Dorian Obino
12. Samy Gobaa
13. Guilllaume Dumenil

• Curated by eLife

  eLife Assessment

  The authors develop an important microfluidic microvascular model called "Vessel-on-Chip", which they use to study Neisseria meningitidis interactions within this in vitro vascular system. Compelling evidence shows that the fabricated channels are lined by endothelial cells, and these can be colonized by N. meningitidis that in turn triggers neutrophil recruitment. This model has advantages over the human skin xenograft mouse model, which requires complex surgical techniques, however, it also carries limitations in that only endothelial cells and supplied specific immune cells in the microfluidics are present, while true vasculature contains a number of other cell types including smooth muscle cells, pericytes, and components of the immune system.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Drug-Induced p53 Activation Limits Pancreatic Cancer Initiation

1. Jennifer J Twardowski
2. Thomas I Heist
3. Zamira Guerra Soares
4. Emily S Berry
5. Luis I Ruffolo
6. Christoph Pröschel
7. Stephano S Mello

Reviewed by Review Commons

Intestinal stem cell renewal controlled by capillary morphogenesis gene 2 following injury

1. Lucie Bracq
2. Audrey Chuat
3. Béatrice Kunz
4. Olivier Burri
5. Romain Guiet
6. F. Gisou van der Goot

Reviewed by Review Commons

The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistence in hepatocytes

1. Ann-Kathrin Mehnert
2. Sebastian Stegmaier
3. Carlos Ramirez
4. Vladimir Gonçalves Magalhães
5. Carla Siebenkotten
6. Jungen Hu
7. Ana Luisa Costa
8. Daniel Kirrmaier
9. Michael Knop
10. Xianfang Wu
11. Thibault Tubiana
12. Carl Herrmann
13. Marco Binder
14. Viet Loan Dao Thi

Reviewed by Review Commons

A myofilament lattice model of Drosophila flight muscle sarcomeres based on multiscale morphometric analysis during development

1. Péter Görög
2. Tibor Novák
3. Tamás F. Polgár
4. Péter Bíró
5. Adél Gutheil
6. Csaba Kozma
7. Tamás Gajdos
8. Krisztina Tóth
9. Alexandra Tóth
10. Miklós Erdélyi
11. József Mihály
12. Szilárd Szikora

Reviewed by Review Commons

A novel approach to tagging tubulin reveals MT assembly dynamics of the axoneme in Trypanosoma brucei

1. Daniel Abbühl
2. Martina Pružincová
3. Luděk Štěpánek
4. Eleonore Bouscasse
5. Rita Azevedo
6. Mariette Matondo
7. Vladimir Varga
8. Serge Bonnefoy
9. Philippe Bastin

Reviewed by Review Commons

Mouse scalp development requires Rac1 and SRF for the maintenance of mechanosensing mesenchyme

1. Bharath H. Rathnakar
2. Alex Rackley
3. Hae Ryong Kwon
4. William L. Berry
5. Lorin E. Olson

Reviewed by Review Commons

A simple method to efficiently generate structural variation in plants

1. Lindsey L. Bechen
2. Naiyara Ahsan
3. Alefiyah Bahrainwala
4. Mary Gehring
5. PRV Satyaki

Reviewed by Review Commons, PREreview

Transcriptional Dynamics and Chromatin Accessibility in the Regulation of Shade-Responsive Genes in Arabidopsis

1. Sandi Paulisic
2. Alessandra Boccaccini
3. René Dreos
4. Giovanna Ambrosini
5. Nicolas Guex
6. Ruben Maximilian Benstei
7. Markus Schmid
8. Christian Fankhauser

Reviewed by Review Commons

The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development

1. M Leone
2. N Kinz
3. F Eichin
4. D Obwegs
5. VC Sladky
6. VZ Braun
7. D Rizzotto
8. L Englmaier
9. C Manzl
10. K Moos
11. Julia Mergner
12. P Giansanti
13. MN Garcia
14. MM Marques
15. ED Jacotot
16. C Savko
17. M Boerries
18. MA Sussman
19. A Villunger

Reviewed by Review Commons

Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways

1. Priyanka Das
2. Ravi
3. Jogender Singh

Reviewed by Review Commons

Different cellular and molecular mechanisms of chitin deposition contribute to the specificity of the two chitin synthases in D. melanogaster

1. Joan Bertran-Mas
2. Ettore De Giorgio
3. Nicolás Martín
4. Marta Llimargas

Reviewed by Review Commons

The secreted Nimrod protein NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

1. Asya Dolgikh
2. Samuel Rommelaere
3. Aseel Ghanem
4. Bianca Petrignani
5. Mickael Poidevin
6. Estee Kurant
7. Bruno Lemaitre

Reviewed by Review Commons

OTX2 controls chromatin accessibility to direct somatic versus germline differentiation

1. Elisa Barbieri
2. Ian Chambers

Reviewed by Review Commons

Transcription can be sufficient, but is not necessary, to advance replication timing

1. Athanasios E. Vouzas
2. Takayo Sasaki
3. Juan Carlos Rivera-Mulia
4. Jesse L. Turner
5. Amber N. Brown
6. Karen E. Alexander
7. Laura Brueckner
8. Bas van Steensel
9. David M. Gilbert

Reviewed by Review Commons

The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice

1. Soomin Cho
2. Emilia Servián-Morilla
3. Victoria Navarro Garrido
4. Beatriz Rodriguez-Gonzalez
5. Youxi Yuan
6. Raquel Cano
7. Arjun A. Rambhiya
8. Radbod Darabi
9. Robert S. Haltiwanger
10. Carmen Paradas
11. Hamed Jafar-Nejad

Reviewed by Review Commons

Polarity reversal of stable microtubules during neuronal development

1. Malina K. Iwanski
2. Albert K. Serweta
3. H. Noor Verwei
4. Bronte C. Donders
5. Lukas C. Kapitein

Reviewed by Review Commons

Ecdysone-mediated intestinal growth contributes to microbiota-driven developmental plasticity under malnutrition

1. Longwei Bai
2. Stéphanie Bellemin
3. Elodie Guillemot
4. Maura Strigini
5. Benjamin Gillet
6. Cathy Isaura Ramos
7. François Leulier

Reviewed by Review Commons

Condensin I ^DC has a Functional ATPase That is Required for X-Chromosome Dosage Compensation in C. elegans

1. Bahaar Chawla
2. Suchi Jatia
3. Dillon E. Sloan
4. Gyorgyi Csankovszki

Reviewed by Review Commons

Targeting de novo cholesterol synthesis in rhabdomyosarcoma induces cell cycle arrest and triggers apoptosis through ER stress-mediated pathways

1. Nebeyu Yosef Gizaw
2. Kalle Kolari
3. Kari Alitalo
4. Riikka Kivelä

Reviewed by Review Commons