Evaluated articles

A list by Review Commons

Articles that have been evaluated by Review Commons.

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  1. Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

    1. Yamato Niitani
    2. Kohei Matsuzaki
    3. Erik Jonsson
    4. Ronald D Vale
    5. Michio Tomishige

    • Curated by eLife

      eLife Assessment

      This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and single-molecule assays, the authors demonstrate that the neck linker's conformation differentially modulates nucleotide affinity and detachment rates, establishing an asynchronous chemo-mechanical cycle that prevents simultaneous detachment. Supported by cryo-EM structural data, the work presents an important advance in our understanding of kinesin's hand-over-hand movement.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    9 evaluationsAppears in 2 listsLatest version Latest activity

  7. CCDC32 stabilizes clathrin-coated pits and drives their invagination

    1. Ziyan Yang
    2. Changsong Yang
    3. Zheng Huang
    4. Peiliu Xu
    5. Yueping Li
    6. Lu Han
    7. Linyuan Peng
    8. Xiangying Wei
    9. John E Pak
    10. Tatyana Svitkina
    11. Sandra L Schmid
    12. Zhiming Chen

    • Curated by eLife

      eLife Assessment

      The manuscript presents a valuable finding that CCDC32, beyond its reported role in AP2 assembly, follows AP2 to the plasma membrane and regulates clathrin-coated pit assembly and dynamics. The authors further identify an alpha-helical region within CCDC32 that is essential for its interaction with AP2 and its cellular function. While live-cell and ultrastructural imaging data are solid, future biochemical studies will be needed to confirm the proposed CCDC32-AP2 interaction.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    14 evaluationsAppears in 2 listsLatest version Latest activity

  12. Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

    1. Pratim Chowdhury
    2. Xiaoli Wang
    3. Richard I. Han
    4. Manga Motrapu
    5. Ashley G. Boice
    6. Yuya Nakatani
    7. Sofia Vargas‐Hernandez
    8. Julia F. Love
    9. Claude Chew
    10. Sandra L. Grimm
    11. Dereck Mezquita
    12. Frank M. Mason
    13. Elisabeth D. Martinez
    14. Cristian Coarfa
    15. Cheryl L. Walker
    16. Anna‐Karin Gustavsson
    17. Ruhee Dere

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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