Evaluated articles

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens

1. Raphael A. Reyes
2. Louise Turner
3. Isaac Ssewanyana
4. Prasanna Jagannathan
5. Margaret E. Feeney
6. Thomas Lavstsen
7. Bryan Greenhouse
8. Sebastiaan Bol
9. Evelien M. Bunnik

Reviewed by Review Commons

Unveiling Gene Perturbation Effects through Gene Regulatory Networks Inference from single-cell transcriptomic data

1. Clelia Corridori
2. Merrit Romeike
3. Giorgio Nicoletti
4. Christa Buecker
5. Samir Suweis
6. Sandro Azaele
7. Graziano Martello

Reviewed by Review Commons

Inflammation and IL-4 regulate Parkinson’s and Crohn’s disease associated kinase LRRK2

1. Dina Dikovskaya
2. Rebecca Pemberton
3. Matthew Taylor
4. Anna Tasegian
5. Purbasha Bhattacharya
6. Karolina Zeneviciute
7. Esther M Sammler
8. Andrew J M Howden
9. Dario R Alessi
10. Mahima Swamy

Reviewed by Review Commons

Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironment

1. Libi Anandi
2. Jeremy Garcia
3. Manon Ros
4. Libuše Janská
5. Josephine Liu
6. Carlos Carmona-Fontaine

Reviewed by Review Commons

Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

1. Sara Formichetti
2. Agnieszka Sadowska
3. Michela Ascolani
4. Julia Hansen
5. Kerstin Ganter
6. Christophe Lancrin
7. Neil Humphreys
8. Mathieu Boulard

Reviewed by Review Commons

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

1. Andrea Cottignies-Calamarte
2. Flora Marteau
3. Feifan He
4. Sandrine Belouzard
5. Jean Dubuisson
6. Daniela Tudor
7. Benoit Viollet
8. Morgane Bomsel

Reviewed by Review Commons

Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers

1. Svanhild Nornes
2. Susann Bruche
3. Niharika Adak
4. Ian R McCracken
5. Sarah De Val

Reviewed by Review Commons

Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans

1. Georgia Maria Sagia
2. Xenia Georgiou
3. Georgios Chamilos
4. George Diallinas
5. Sofia Dimou

Reviewed by Review Commons

Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways

1. Melissa Lubeck
2. Ritam Naha
3. Yulia Schaumkessel
4. Philipp Westhoff
5. Anja Stefanski
6. Patrick Petzsch
7. Kai Stühler
8. Karl Köhrer
9. Andreas P. M. Weber
10. Ruchika Anand
11. Andreas S. Reichert
12. Arun Kumar Kondadi

Reviewed by Review Commons

Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol

1. Salam Dabsan
2. Gali Zur
3. Naim Abu-Freha
4. Shahar Sofer
5. Iris Grossman-Haham
6. Ayelet Gilad
7. Aeid Igbaria

Reviewed by Review Commons

In vivo mapping of protein-protein interactions of schizophrenia risk factors generates an interconnected disease network

1. Daniel B. McClatchy
2. Susan B. Powell
3. John R. Yates

Reviewed by Review Commons

DNA replication in primary hepatocytes without the six-subunit ORC

1. Róża K Przanowska
2. Yuechuan Chen
3. Takayuki-Okano Uchida
4. Etsuko Shibata
5. Xiaoxiao Hao
6. Isaac Segura Rueda
7. Kate Jensen
8. Piotr Przanowski
9. Anthony Trimboli
10. Yoshiyuki Shibata
11. Gustavo Leone
12. Anindya Dutta

• Curated by eLife

  eLife Assessment

  This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data using various methods to genetically remove one or two ORC subunits from specific tissues and still observe replication. The replication appears to be primarily endoreduplication, indicating that ORC-independent replication may promote genome reduplication without mitosis. The mechanism behind this ORC-independent replication remains to be elucidated. The study and mutants described herein lay the groundwork for future research to explore how cells compensate for the absence of ORC and to develop functional approaches to investigate this process. The reviewers suggested the observations could be supported by additional experiments. This work will be of interest to those studying genome duplication and replication.

Reviewed by eLife, Review Commons

Capturing cell heterogeneity in representations of cell populations for image-based profiling using contrastive learning

1. Robert van Dijk
2. John Arevalo
3. Mehrtash Babadi
4. Anne E. Carpenter
5. Shantanu Singh

Reviewed by Review Commons

Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain

1. Deepanshu N. D. Singh
2. Abigail R. E. Roberts
3. Xiaocui Wang
4. Guiyi Li
5. Enrique Quesada Moraga
6. David Alliband
7. Elizabeth Ballou
8. Hung-Ji Tsai
9. Alicia Hidalgo

Reviewed by Review Commons

A Lgr5-independent developmental lineage is involved in mouse intestinal regeneration

1. Maryam Marefati
2. Valeria Fernandez-Vallone
3. Morgane Leprovots
4. Gabriella Vasile
5. Frédérick Libert
6. Anne Lefort
7. Gilles Dinsart
8. Achim Weber
9. Jasna Jetzer
10. Marie-Isabelle Garcia
11. Gilbert Vassart

Reviewed by Review Commons

Mechanisms of cilia regeneration in Xenopus multiciliated epithelium in vivo

1. Venkatramanan G. Rao
2. Vignesharavind Subramanianbalachandar
3. Magdalena M. Magaj
4. Stefanie Redemann
5. Saurabh S. Kulkarni

Reviewed by Review Commons, Arcadia Science

An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans

1. Milán Somogyvári
2. Saba Khatatneh
3. Gábor Hajdú
4. Bar Sotil
5. József Murányi
6. Csaba Sőti

Reviewed by Review Commons

Ca ²⁺ binding to Esyt is required to modulate membrane contact site density in Drosophila photoreceptors

1. Vaisaly R Nath
2. Harini Krishnan
3. Shirish Mishra
4. Padinjat Raghu

Reviewed by Review Commons

Interferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System

1. Rameez Raja
2. Banhi Biswas
3. Rachy Abraham
4. Hongrui Liu
5. Che-Yuan Chang
6. Hien Vu
7. Anthony K. L. Leung

Reviewed by PREreview, Review Commons

Bellymount-pulsed tracking: a novel approach for real-time in vivo imaging of Drosophila abdominal tissues

1. Shruthi Balachandra
2. Amanda A Amodeo

Reviewed by Review Commons