Evaluated articles

Translational buffering tunes gene expression in mice and humans

1. Shilpa Rao
2. Aden Y. Le
3. Logan Persyn
4. Can Cenik

Reviewed by Review Commons

Trisomy 21 Impairs Synchronized Activity in Human Down Syndrome Cortical Excitatory Neuron Networks

1. Manuel Peter
2. Raquel Real
3. Alessio Strano
4. Hugh P. C. Robinson
5. Mark A. Smith
6. Samuel J. Barnes
7. Tania Dutta
8. Vincenzo De Paola
9. Frederick J. Livesey

Reviewed by Review Commons

Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D

1. Diana Marcu
2. David R Sannino
3. Anthony J Dornan
4. Rita Ibrahim
5. Atharv Kapoor
6. Miriam Wood
7. Adam J Dobson

• Curated by eLife

  eLife Assessment

  This important study demonstrates that in Drosophila melanogaster, tachykinin (Tk) expression is regulated by the microbiota. The authors present convincing evidence that axenic flies raised with no microbiota are longer-lived than conventionally reared animals, and that Tk expression and Tk receptors in the nervous system are required for this effect. They further test individual bacterial strains for their role in these effects and connect the effect to loss of lipid stores and suggest that FOXO may be involved in the phenotype, results that are of interest to the fields of environmental perception, host microbiome interactions, and geroscience.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Chronic replication stress-mediated genomic instability disrupts placenta development in mice

1. Mumingjiang Munisha
2. Rui Huang
3. Jordan Khan
4. John C. Schimenti

Reviewed by Review Commons

miR-184 modulates Ilp8 to control developmental timing during normal growth conditions and in response to developmental perturbations

1. Jervis Fernandes
2. Muhammed Naseem
3. Ayisha Marwa Mangattu Parambil
4. Jishy Varghese

Reviewed by Review Commons

The Ketogenic Diet Metabolite β-Hydroxybutyrate Promotes Mitochondrial Elongation via Deacetylation in HeLa Cells and Improves Autism-like Behavior in Zebrafish

1. Golam Mezbah Uddin
2. Rachel Lacroix
3. Mashiat Zaman
4. Iman Al Khatib
5. Amit Jaiswal
6. Jong Rho
7. Deborah Kurrasch
8. TIM SHUTT

Reviewed by Review Commons

When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion

1. Lisa Dengler
2. Francesco Padovani
3. Bianca Lemke
4. Rebecca Brugger
5. Benedikt Westermann
6. Boris Maček
7. Kurt M. Schmoller
8. Jennifer C. Ewald

Reviewed by Review Commons

Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3

1. Machika Kaku
2. Marta Maria Gaglia

Reviewed by Review Commons

Global molecular landscape of early MASLD progression in human obesity

1. Qing Zhao
2. William De Nardo
3. Ruoyu Wang
4. Yi Zhong
5. Umur Keles
6. Gabriele Sakalauskaite
7. Li Na Zhao
8. Huiyi Tay
9. Sonia Youhanna
10. Mengchao Yan
11. Ye Xie
12. Youngrae Kim
13. Sungdong Lee
14. Rachel Liyu Lim
15. Guoshou Teo
16. Pradeep Narayanaswamy
17. Paul R Burton
18. Volker M Lauschke
19. Hyungwon Choi
20. Matthew J Watt
21. Philipp Kaldis

• Curated by eLife

  eLife Assessment

  The authors provide a useful resource and approach to identify early-stage biomarkers of MASLD progression, notably when no other apparent symptoms have arisen. The strength of evidence to support new MASLD signatures is solid as the work combines metabolomic and transcriptomic measures in blood and liver biopsies.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Assessing target genes for homing suppression gene drive

1. Xuejiao Xu
2. Jialing Fang
3. Jingheng Chen
4. Jie Yang
5. Xiaozhen Yang
6. Shibo Hou
7. Weitang Sun
8. Jackson Champer

Reviewed by Review Commons

E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression

1. Fernando Valdivieso-Rivera
2. Vanessa O. Furino
3. Carlos E. Leher
4. Ariane M. Zanesco
5. Monara Kaélle Cruz
6. Flavia C. Gan
7. Adriana Leandra Santoro
8. Lara Regina-Ferreira
9. Giovanna Leite Santos
10. Tiago Gonçalves
11. Luiz Osório Leiria
12. Pedro M. Moraes-Vieira
13. Roger Frigério Castilho
14. Shingo Kajimura
15. Marcelo A. Mori
16. Licio A. Velloso
17. Carlos H. Sponton

Reviewed by Review Commons

Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems

1. Francisco-Javier Garcia-Rodriguez
2. Camila Valenzuela
3. Joaquin Bernal-Bayard
4. Pedro Escoll

Reviewed by Review Commons

Multi-omics analysis of endothelial cells reveals the metabolic diversity that underlies endothelial cell functions

1. Stephan Durot
2. Peter F. Doubleday
3. Lydia Schulla
4. Amélie Sabine
5. Tatiana V. Petrova
6. Nicola Zamboni

Reviewed by Review Commons

Spatial control of secretory vesicle targeting by the Ync13–Rga7– Rng10 complex during cytokinesis

1. Sha Zhang
2. Davinder Singh
3. Yi-Hua Zhu
4. Katherine J. Zhang
5. Alejandro Melero
6. Sophie G. Martin
7. Jian-Qiu Wu

Reviewed by Review Commons

Multiciliated cells adapt the mechanochemical Piezo1-Erk1/2-Yap1 cell proliferation axis to fine-tune centriole number

1. Vani Narayanan
2. Venkatramanan G Rao
3. Angelo Arrigo
4. Saurabh S Kulkarni

Reviewed by Review Commons

Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers

1. Martina Demurtas
2. Samantha M. Barnada
3. Emma van Domselaar
4. Zoe H. Mitchell
5. Laura Deelen
6. Marco Trizzino

Reviewed by Review Commons

Local synthesis of Reticulon-1C lessens the outgrowth of injured axons and Spastin activity

1. Alejandro Luarte
2. Javiera Gallardo
3. Daniela Corvalán
4. Ankush Chakraborty
5. Cláudio Gouveia-Roque
6. Francisca Bertin
7. Carlos Contreras
8. Juan Pablo Ramírez
9. André Weber
10. Waldo Acevedo
11. Werner Zuschratter
12. Rodrigo Herrera-Molina
13. Úrsula Wyneken
14. Andrea Paula-Lima
15. Tatiana Adasme-Rocha
16. Jorge Toledo
17. Rodrigo Vergara
18. Antonia Figueroa
19. Carolina González
20. Christian González-Billault
21. Ulrich Hengst
22. Andrés Couve

Reviewed by Review Commons

Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation

1. Lina Worpenberg
2. Cédric Gobet
3. Felix Naef

Reviewed by Review Commons

The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

1. Anthony E. Jones
2. Amy Rios
3. Neira Ibrahimovic
4. Carolina Chavez
5. Nicholas A. Bayley
6. Andréa B. Ball
7. Wei Yuan Hsieh
8. Alessandro Sammarco
9. Amber R. Bianchi
10. Angel A. Cortez
11. Thomas G. Graeber
12. Alexander Hoffmann
13. Steven J. Bensinger
14. Ajit S. Divakaruni

Reviewed by Review Commons

Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapses

1. Serena Camuso
2. Yana Vella
3. Souad Youjil Abadi
4. Clémence Mille
5. Bert Brône
6. Christian G Specht

• Curated by eLife

  eLife Assessment

  The study presents convincing quantitative evidence, supported by appropriate negative controls, for the presence of low-abundance glycine receptors (GlyRs) within inhibitory synapses in telencephalic regions of the mouse brain. Using sensitive single-molecule localization microscopy of endogenously tagged GlyRs, the authors reveal previously undetected populations of these receptors. Although the functional significance of these low-abundance GlyRs remains to be established, the findings offer valuable insights and methodologies that will be of interest to neuroscientists studying inhibitory synapse biology.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons