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  1. Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors

    This article has 16 authors:
    1. Anahí Binagui-Casas
    2. Anna Granés
    3. Alberto Ceccarelli
    4. Filip J. Wymeersch
    5. Matthew French
    6. Rosa Portero
    7. Jen Annoh
    8. Yali Huang
    9. Eleni Karagianni
    10. Frederick C.K. Wong
    11. A. Sophie Brumm
    12. Daniel Lopez Ramajo
    13. Minoru Takasato
    14. Sally Lowell
    15. Osvaldo Chara
    16. Valerie Wilson

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets

    This article has 15 authors:
    1. Rianne G Bouma
    2. Willem-Jan de Leeuw
    3. Aru Z Wang
    4. Muddassir Malik
    5. Joeke GC Stolwijk
    6. Veronique AL Konijn
    7. Anne Mensink
    8. Natalie Proost
    9. Maarten K Nijen Twilhaar
    10. Tibor van Welsem
    11. Negisa Seyed Toutounchi
    12. Alsya J Affandi
    13. Jip T van Dinter
    14. Fred van Leeuwen
    15. Joke MM den Haan

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

    This article has 8 authors:
    1. Ioakeim Ampartzidis
    2. Elliott M Thompson
    3. Yashica Gupta
    4. Andrea Krstevski
    5. Nicola Elvassore
    6. Eirini Maniou
    7. Paolo de Coppi
    8. Gabriel L Galea
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors used genetic mutations in VANGL2 to study cell morphological changes during differentiation of hPSCs and understand the mechanisms underlying neural tube closure defects. The findings are important as they establish a quantitative, reproducible 2D human iPSC-to-neural-progenitor platform for analyzing cell-shape dynamics during differentiation. The convincing evidence provided, combined with the relative simplicity of the model and its tractability as a patient-specific and reverse genetic platform, make it attractive.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity