Evaluated articles

Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut

1. Qingyin Qian
2. Hiroki Nagai
3. Yuya Sanaki
4. Makoto Hayashi
5. Kenichi Kimura
6. Yu-ichiro Nakajima
7. Ryusuke Niwa

Reviewed by Review Commons

The nanosd integral gene drive enables population modification of the malaria vector Anopheles gambiae

1. Pei-Shi Yen
2. Sebald A N R Verkuijl
3. Paolo Capriotti
4. Giuseppe Del Corsano
5. Calvin Kim Guan Yee
6. Astrid Hoermann
7. Maria Grazia Inghilterra
8. Irati Aramburu-Gonzalez
9. Moeez A Khan
10. Dina Vlachou
11. George K Christophides
12. Nikolai Windbichler

Reviewed by Rapid Reviews Infectious Diseases, Review Commons

A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment

1. Igor Bonacossa-Pereira
2. Sean Coakley
3. Massimo A. Hilliard

Reviewed by Review Commons

High-resolution mapping of the actin fusion focus reveals myosin V–dependent formin transport for aster formation

1. Valentine Thomas
2. Hikari Mase
3. Laetitia Michon
4. Andrea Picco
5. Marko Kaksonen
6. Sophie G. Martin

Reviewed by Review Commons

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

1. Kamila J Bienkowska
2. Stephany Gallardo Y
3. Nur S Zainal
4. Matthew Ellis
5. Maria-Antoinette Lopez
6. Judith Austine
7. Sai Pittla
8. Serena J Chee
9. Aiman Alzetani
10. Emily C Shaw
11. Christian H Ottensmeier
12. Gareth J Thomas
13. Christopher J Hanley

Reviewed by Review Commons

MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

1. Julie C. Nielsen
2. Maria Benito-Jardon
3. Noel Christo Petrela
4. Jessica Diring
5. Sofie Bellamy
6. Richard Treisman

Reviewed by Review Commons

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ-dependent but monocyte-independent process

1. Marlene Magalhaes Pinto
2. Bert Malengier-Devlies
3. Guillaume Seuzaret
4. Anna Ahlback
5. Solvig Becker
6. Katelyn Patatsos
7. Georgios Drakoulis
8. Julia Karjalainen
9. Christiane Ruedl
10. David Voehringer
11. Calum C Bain
12. Elaine Emmerson
13. Barbora Schonfeldova
14. Kristina Zec
15. Irina Udalova
16. Theodoros Simakou
17. Lucy MacDonald
18. Mariola Kurowska-Stolarska
19. Jadwiga Zarebska
20. Tonia Vincent
21. Romeo Ricci
22. Eric Erbs
23. Jack Barrington
24. Barry W McColl
25. Georgiana Neag
26. Samuel Kemble
27. Christopher Mahony
28. Adam Croft
29. Louis Boon
30. Nicole Migotsky
31. Megan L Killian
32. Oumaima Ben Brahim
33. Stefan Uderhardt
34. Alexandre Gallerand
35. Stoyan Ivanov
36. Rebecca Gentek

Reviewed by Review Commons

Bat Dicer antiviral role and subcellular localization differ upon alphavirus infection in two distinct species

1. Léa Gaucherand
2. Hugo Marie
3. Julie Cremaschi
4. Sébastien Pfeffer

Reviewed by Review Commons

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in Drosophila

1. Wei Qi Guinevere Sew
2. Maria Molano-Fernández
3. Zhiquan Li
4. Artim Lange
5. Nahia Pérez de Ciriza
6. Lene Juel Rasmussen
7. Héctor Herranz

Reviewed by Review Commons

NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans

1. Paola V. Figueroa-Delgado
2. Shaul Yogev

Reviewed by Review Commons

SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis

1. Carmen Figueras-Novoa
2. Lewis Timimi
3. Elena Marcassa
4. Raquel Taveira-Marques
5. Lorin Adams
6. Ming Jiang
7. Mary Wu
8. Beatriz Montaner
9. Kevin Ng
10. Giuditta De Lorenzo
11. Wilhelm Furnon
12. Vanessa M. Cowton
13. Nicole Upfold
14. George Kassiotis
15. Ruth Harvey
16. Arvind H Patel
17. Michael Howell
18. Rachel Ulferts
19. Rupert Beale

Reviewed by Review Commons

Phage-encoded TelN inhibits bacterial Mre11-Rad50 nuclease to protect hairpin telomeres

1. Maya Houmel
2. Nicolas Pellaton
3. Anna Anchimiuk
4. Stephan Gruber

Reviewed by Review Commons

Magnesium depletion unleashes two unusual modes of colistin resistance with different fitness costs

1. Yu-Ying Phoebe Hsieh
2. Ian P. O’Keefe
3. Zeqi Wang
4. Wanting Sun
5. Hyojik Yang
6. Linda M. Vu
7. Robert K. Ernst
8. Ajai A. Dandekar
9. Harmit S. Malik

Reviewed by Review Commons

Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development

1. Vivek Bhardwaj
2. Alberto Griffa
3. Helena Viñas Gaza
4. Peter Zeller
5. Alexander van Oudenaarden

• Curated by eLife

  eLife Assessment

  In this valuable study, the authors examine transcription and chromatin dynamics during early zebrafish development by simultaneously profiling histone modifications and full-length transcriptomes in thousands of single cells, providing solid analysis that chromatin and transcriptional states are initially weakly correlated in early embryonic cells and become progressively more aligned as differentiation proceeds. The work also supports a model in which promoter-anchored cis-spreading of H3K27me3 contributes to stable gene silencing during development. Future functional perturbations and orthogonal validations will be needed to determine the causal contribution of Polycomb spreading to fate commitment. Overall, the dataset and accompanying analyses provide a robust resource and a quantitative framework for studying chromatin-transcription relationships during vertebrate embryogenesis.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling

1. Thomas Hale
2. Victoria L. Hale
3. Piotr Kolata
4. Ália dos Santos
5. Matteo Allegretti

Reviewed by preLights, Review Commons

Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system

1. Christopher B. Nelson
2. Jadon K. Wells
3. Ekaagra Kesarwani
4. Alexander P. Sobinoff
5. Jixuan Gao
6. Karen L. MacKenzie
7. Rebecca C. Poulos
8. Urwah Nawaz
9. Xiang Wang
10. Heide L. Ford
11. Hilda A. Pickett

Reviewed by Review Commons

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

1. Maria Llamazares Prada
2. Uwe Schwartz
3. Darius F. Pease
4. Stephanie T. Pohl
5. Deborah Ackesson
6. Renjiao Li
7. Annika Behrendt
8. Raluca Tamas
9. Mandy Richter
10. Thomas Muley
11. Joschka Hey
12. Elisa Espinet
13. Claus P. Heußel
14. Arne Warth
15. Mark Schneider
16. Hauke Winter
17. Felix Herth
18. Charles D Imbusch
19. Benedikt Brors
20. Vladimir Benes
21. David Wyatt
22. Tomasz P. Jurkowski
23. Heiko F. Stahl
24. Christoph Plass
25. Renata Z. Jurkowska

Reviewed by Review Commons

Actin cytoskeletal deregulation, caused by RhoGEF2 overexpression, induces cell competition dependent on Ptp10D, Crumbs, and the Hippo signaling pathway

1. Natasha Fahey-Lozano
2. Marta Portela
3. John E. La Marca
4. Helena E. Richardson

Reviewed by Review Commons

A push-pull system of repressors matches levels of glucose transporters to extracellular glucose in budding yeast

1. Luis Fernando Montaño-Gutierrez
2. Marc Sturrock
3. Iseabail Farquhar
4. Kevin Correia
5. Vahid Shahrezaei
6. Peter S. Swain

Reviewed by Review Commons

Proximity Labeling of NIMA Kinase Complex Components in C. elegans

1. David S. Fay
2. Boopathi Balasubramaniam
3. Sean M. Harrington
4. Philip T. Eden

Reviewed by Review Commons