Evaluated articles

A list by Review Commons

Articles that have been evaluated by Review Commons.

1310 articlesLast updated

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  1. Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription

    1. ChaĂŻma Azouzi
    2. Katrin Schwank
    3. Sophie Queille
    4. Marta Kwapisz
    5. Marion Aguirrebengoa
    6. Anthony Henras
    7. Simon Lebaron
    8. Herbert Tschochner
    9. Annick Lesne
    10. Frédéric Beckouët
    11. Olivier Gadal
    12. Christophe Dez

    • Curated by eLife

      eLife Assessment

      This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present convincing evidence that demonstrates the existence of premature termination in Pol I transcription. Overall, the characterization of this RNA pol I offers important insights into the regulation of ribosomal RNA transcription and its potential application in cancer pharmacology.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    14 evaluationsAppears in 2 listsLatest version Latest activity

  2. Modularity of the segmentation clock and morphogenesis

    1. James E Hammond
    2. Ruth E Baker
    3. Berta Verd

    • Curated by eLife

      eLife Assessment

      This valuable manuscript uses mathematical modeling to address the synchrony of the vertebrate segmentation clock with the developmental processes. The authors use convincing arguments to support the idea that this would allow the evolution of flexible body plans and a variable number of segments. This manuscript could be of interest to developmental biologists and systems biologists.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    9 evaluationsAppears in 2 listsLatest version Latest activity

  4. Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patients

    1. Roni Ben-Ami
    2. Netanel Loyfer
    3. Eden Cohen
    4. Gavriel Fialkoff
    5. Israa Sharkia
    6. Naama Bogot
    7. Danit Kochan
    8. George Kalak
    9. Amir Jarjoui
    10. Chen Chen-Shuali
    11. Hava Azulai
    12. Hezi Barhoum
    13. Nissim Arish
    14. Moshe M Greenberger
    15. David Vellema
    16. Ramzi Kurd
    17. Eli Ben Chetrit
    18. Davina Bohm
    19. Talya Wolak
    20. Ahmad Quteineh
    21. Gordon Cann
    22. Benjamin Glaser
    23. Nir Friedman
    24. Tommy Kaplan
    25. Ruth Shemer
    26. Ariel Rokach
    27. Yuval Dor

    Reviewed by Review Commons, Rapid Reviews Infectious Diseases

    6 evaluationsAppears in 2 listsLatest version Latest activity

  6. Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

    1. Nadine Tuechler
    2. Mira Lea Burtscher
    3. Martin Garrido-Rodriguez
    4. Muzamil Majid Khan
    5. DĂ©nes TĂĽrei
    6. Christian Tischer
    7. Sarah Kaspar
    8. Jennifer Jasmin Schwarz
    9. Frank Stein
    10. Mandy Rettel
    11. Rafael Kramann
    12. Mikhail M Savitski
    13. Julio Saez-Rodriguez
    14. Rainer Pepperkok

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

    1. Yamato Niitani
    2. Kohei Matsuzaki
    3. Erik Jonsson
    4. Ronald D Vale
    5. Michio Tomishige

    • Curated by eLife

      eLife Assessment

      This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and single-molecule assays, the authors demonstrate that the neck linker's conformation differentially modulates nucleotide affinity and detachment rates, establishing an asynchronous chemo-mechanical cycle that prevents simultaneous detachment. Supported by cryo-EM structural data, the work presents an important advance in our understanding of kinesin's hand-over-hand movement.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    9 evaluationsAppears in 2 listsLatest version Latest activity

  16. CCDC32 stabilizes clathrin-coated pits and drives their invagination

    1. Ziyan Yang
    2. Changsong Yang
    3. Zheng Huang
    4. Peiliu Xu
    5. Yueping Li
    6. Lu Han
    7. Linyuan Peng
    8. Xiangying Wei
    9. John Pak
    10. Tatyana Svitkina
    11. Sandra L Schmid
    12. Zhiming Chen

    • Curated by eLife

      eLife Assessment

      The manuscript presents a valuable finding that CCDC32, beyond its reported role in AP2 assembly, follows AP2 to the plasma membrane and regulates clathrin-coated pit assembly and dynamics. The authors further identify an alpha-helical region within CCDC32 that is essential for its interaction with AP2 and its cellular function. While live-cell and ultrastructural imaging data are solid, future biochemical studies will be needed to confirm the proposed CCDC32-AP2 interaction.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    14 evaluationsAppears in 2 listsLatest version Latest activity
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