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  1. Synaptic Encoding of Time in Working Memory

    This article has 2 authors:
    1. Gianluigi Mongillo
    2. Misha Tsodyks
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    • Curated by eLife

      eLife Assessment

      This valuable manuscript addresses the longstanding question of how the brain maintains serial order in working memory, proposing a biologically grounded model based on synaptic augmentation mechanisms that operates on longer time scales than facilitation. The authors show that augmentation provides a mechanism by which this order can be maintained in memory thanks to a temporal gradient of synaptic efficacies. Although the evidence remains incomplete at present, it can be made compelling by demonstrating robustness to network heterogeneity, spiking, and threshold values for encoding the working memory.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. The evolution of interdisciplinarity and internationalization in scientific journals

    This article has 2 authors:
    1. Huaxia Zhou
    2. Luis A.N. Amaral
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    • Curated by eLife

      eLife Assessment

      This important study uses data on over 56 million articles to examine the dynamics of interdisciplinarity and international collaborations in research journals. The data analytics used to quantify disciplinary and national diversity are convincing, and support the claims that journals have become more diverse in both aspects.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Single neurons detect spatiotemporal activity transitions through STP and EI imbalance

    This article has 2 authors:
    1. Aditya Asopa
    2. Upinder Singh Bhalla
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    • Curated by eLife

      eLife Assessment

      This useful study examines excitation/inhibition (E/I) balance in the CA3-CA1 circuit of the hippocampus. Experimental and computational modeling results are presented, but these results provide incomplete evidence to support the paper's main claims due to shortcomings in the experimental and modeling approaches, as well as concerns about the neurobiological relevance of the results.

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  4. Quantifying Intracellular Mechanosensitive Response upon Spatially Defined Mechano-Chemical Triggering

    This article has 5 authors:
    1. Elaheh Zare-Eelanjegh
    2. Renard T.M. Lewis
    3. Ines Lüchtefeld
    4. Ulrike Kutay
    5. Tomaso Zambelli
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    • Curated by eLife

      eLife Assessment

      This valuable study provides evidence that the integration of the nuclear envelope into the endoplasmic reticulum provides a mechanism for mechanical integration across this continuous membrane system. If robustly demonstrated, this work would open up new avenues for studying organelle membrane tension homeostasis. While the evidence is largely convincing and carefully quantified, a key limitation is the absence of data demonstrating that microinjection of cytoskeleton-depolymerizing drugs locally disrupts the target network.

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  5. Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons

    This article has 14 authors:
    1. Amanda Essoh
    2. Himanshu Gangal
    3. Zhenbo Huang
    4. Ruifeng Chen
    5. Xueyi Xie
    6. Xuehua Wang
    7. Valerie Vierkant
    8. Miguel Garza
    9. Lierni Ugartemendia
    10. Maria E. Secci
    11. Nicholas W. Gilpin
    12. Nicholas J. Justice
    13. Robert O. Messing
    14. Jun Wang
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    • Curated by eLife

      eLife Assessment

      This important study identifies a novel CRF-positive projection from the central amygdala and BNST to dorsal striatal cholinergic interneurons, revealing a previously unrecognized pathway by which stress signals modulate striatal function. The authors present strong and convincing evidence for the anatomical and functional connectivity of this circuit and demonstrate that alcohol disrupts CRF-mediated cholinergic activity, supporting its relevance to alcohol use disorder.

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  6. The Lipocone Superfamily: A Unifying Theme In Metabolism Of Lipids, Peptidoglycan And Exopolysaccharides, Inter-Organismal Conflicts And Immunity

    This article has 3 authors:
    1. A. Maxwell Burroughs
    2. Gianlucca G. Nicastro
    3. L Aravind
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    • Curated by eLife

      eLife Assessment

      This fundamental study presents a compelling and comprehensive analysis of the newly defined Lipocone superfamily, offering unprecedented insights into the evolutionary origins of Wnt proteins. The authors provide evidence that this superfamily evolved from membrane proteins. The work is exemplary in its use of sequence analysis and structural modeling and will be of broad interest to researchers studying protein evolution and enzymology.

      [Editors' note: this paper was reviewed by Review Commons.]

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway

    This article has 12 authors:
    1. Esther Liu
    2. Matthew Wright
    3. Andrew O. Kearney
    4. Tiffany Caza
    5. Johnson Y. Yang
    6. Valerie Garcia
    7. Amal O. Dadi
    8. Shuta Ishibe
    9. Navdeep S. Chandel
    10. Hanrui Zhang
    11. Edward B. Thorp
    12. Jennie Lin
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      eLife Assessment

      The authors study how apolipoprotein L1 variants impact inflammation and lipid accumulation in macrophages. The findings will be useful for researchers investigating macrophage metabolism and inflammation. The discovery that the polyamine spermidine in part mediates such effects is interesting, but the supporting evidence for a physiologically relevant role is currently incomplete due to the lack of relevant in vivo studies.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. The influence of temporal context on vision over multiple time scales

    This article has 2 authors:
    1. Kacie Lee
    2. Reuben Rideaux
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    • Curated by eLife

      eLife Assessment

      This is a valuable study on how past sensory experiences shape perception across multiple time scales. Using a behavioural task and reanalysed EEG data, the authors identify two unifying mechanisms across time scales: a process resulting in faster responses to expected stimuli modulated by attention to task, and reduced early decoding precision for expected inputs interpreted as dampened feedforward processing. The manipulation to dissociate task-related and unrelated history effects over multiple timescales is novel and promising, but the evidence is incomplete and could be strengthened by clarifying the measures, justifying analyses choices, and the relationship to other work.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. SoxB1 family members inhibit Wnt signaling to promote maturation and deposition of stable neuromasts by the zebrafish Posterior Lateral Line primordium

    This article has 7 authors:
    1. Greg Palardy
    2. Kyeong-won Yoo
    3. Sana Fatma
    4. Abhishek Mukherjee
    5. Chongmin Wang
    6. Priyanka Ravi
    7. Ajay B Chitnis
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    • Curated by eLife

      eLife Assessment

      This important study explores the regulation of collective cell migration and tissue patterning in the zebrafish posterior lateral line primordium by SoxB1 transcription factors. The authors provide evidence that SoxB1 genes interact with Wnt and Fgf signaling pathways to control neuromast deposition and spacing, a process central to sensory organ development. The work offers mechanistic insight into the self-organization of migrating tissues and adds to the understanding of how transcriptional networks integrate with signaling pathways during morphogenesis. However, the strength of the evidence supporting several key conclusions is incomplete due to insufficient validation of mutant and knockdown tools, lack of quantitative analysis, and unclear experimental design details; additional quantification and more rigorous verification of gene knockdown or loss-of-function tools are needed to support the proposed model.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Correlates of protection against African swine fever virus identified by a systems immunology approach

    This article has 12 authors:
    1. Kirill Lotonin
    2. Francisco Brito
    3. Kemal Mehinagic
    4. Obdulio García-Nicolás
    5. Matthias Liniger
    6. Noelle Donzé
    7. Sylvie Python
    8. Stephanie Talker
    9. Tosca Ploegaert
    10. Nicolas Ruggli
    11. Charaf Benarafa
    12. Artur Summerfield
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    • Curated by eLife

      eLife Assessment

      This study provides valuable findings regarding potential correlates of protection against the African swine fever virus. The evidence supporting the claims is solid, although analysis using a higher number of animals and other virus strains will be required to further evaluate the relevance of the immune parameters associated to protection. The work will be of broad interest to veterinary immunologists, and particularly those working on African swine fever.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  11. Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

    This article has 17 authors:
    1. Giulia Arecchi
    2. Marica Dente
    3. Weikang Ma
    4. Beatrice Scellini
    5. Nicoletta Piroddi
    6. Marina Scardigli
    7. Jingyuan Yu
    8. Jing Zhao
    9. Riccardo Cicchi
    10. Ryo Kinegawa
    11. Caroline Muellenbroich
    12. Corrado Poggesi
    13. Cecilia Ferrantini
    14. Thomas C Irving
    15. Michael Regnier
    16. Leonardo Sacconi
    17. Chiara Tesi
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    • Curated by eLife

      eLife Assessment

      Arecchi et al. demonstrate that polarized second-harmonic generation microscopy can be used to probe the ON/OFF states of myosin in both permeabilized and intact muscle, making this key measurement accessible to a greater number of labs. This has the potential to help with the study of disease-causing mutations and our understanding of drug function. The methodology is well defined, and the results are important; however, whilst this is overall a convincing study, there are some limitations to the interpretation of the data.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  12. Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

    This article has 11 authors:
    1. Gabriel M. Kline
    2. Lisa Boinon
    3. Adrian Guerrero
    4. Sergei Kutseikin
    5. Gabrielle Cruz
    6. Marnie P. Williams
    7. Ryan J. Paxman
    8. William E. Balch
    9. Jeffery W. Kelly
    10. Tingwei Mu
    11. R. Luke Wiseman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis remodeling. The evidence supporting the conclusions is convincing, with rigorous assays used to benchmark the changes in potency and efficacy of the AA263 analogs as well as AA263 targets. The ability of AA263 analogs to restore the loss of function associated with disease-associated proteins prone to misfolding will be of interest to pharmacologists, chemical biologists, and cell biologists, as well as those working on protein misfolding disorders.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  13. Convergent Cellular Adaptation to Freeze-Thaw Stress via a Quiescence-like State in Yeast

    This article has 9 authors:
    1. Charuhansini Tvishamayi
    2. Farhan Ali
    3. Nandita Chaturvedi
    4. Nithila Madhu-Kumar
    5. Zeenat Rashida
    6. Chandan Muni Reddy
    7. Ankita Ray
    8. Stephan Herminghaus
    9. Shashi Thutupalli
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    • Curated by eLife

      eLife Assessment

      This important study demonstrates that yeast populations can rapidly evolve freeze-thaw tolerance by converging on a trehalose-rich, quiescence-like state, illuminating a general physiological route to extreme-stress adaptation. The evidence is solid, combining rigorous experimental-evolution design with multi-scale phenotyping, biophysical measurements, whole-genome sequencing, and quantitative modeling that together support the mechanistic conclusions. Questions about the novelty relative to prior growth/stress tolerance links, the precise genetic versus non-genetic drivers of trehalose up-regulation, and the breadth of independently evolved lines. These are areas for clarification, but these do not substantially weaken the overall contribution.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  14. SMC complex unidirectionally translocates DNA by coupling segment capture with an asymmetric kleisin path

    This article has 4 authors:
    1. Masataka Yamauchi
    2. Giovanni B Brandani
    3. Tsuyoshi Terakawa
    4. Shoji Takada
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    • Curated by eLife

      eLife Assessment

      This important study presents a well-constructed multiscale simulation framework to investigate ATP-driven DNA translocation by prokaryotic SMC complexes, supporting a segment-capture mechanism. The strength of evidence is convincing, highlighting the necessity of a precise balance between electrostatic interactions and hydrogen bonding, as well as the critical role of kleisin asymmetry in ensuring unidirectional movement.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  15. Striatal Crosstalk Between Dopamine and Serotonin Systems

    This article has 3 authors:
    1. Yu Liu
    2. Juan Enriquez Traba
    3. Christian Lüscher
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study employs optogenetics, genetically-encoded dopamine and serotonin sensors, and patch-clamp electrophysiology to investigate modulations of neurotransmitter release between striatal dopamine and serotonin neurons - a topic of interest to neuroscientists studying the basal ganglia. The results suggest that the dopamine and serotonin systems operate largely in parallel, with the activation of serotonin neurons resulting in a small, transient dopamine release. The authors suggest that this interaction occurs via glutamate release in the ventral tegmental area, findings that are closely related to previous work. Some conclusions are incomplete requiring larger samples-sizes and controls.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  16. High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain

    This article has 6 authors:
    1. Hongyang Wu
    2. Yoh Maekawa
    3. Sayaka Eno
    4. Shu Kondo
    5. Nobuhiro Yamagata
    6. Hiromu Tanimoto
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work introduces a splitGFP-based labeling tool with an analysis pipeline for the synaptic scaffold protein bruchpilot, with tests in the adult Drosophila mushroom bodies, a learning center in the Drosophila brain. The evidence supporting the conclusions is solid. However, additional controls, validation of synapse-specificity, validation of activity-dependence, details on image processing, and additional functional experiments are needed to strengthen the study.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  17. Developmental constraints mediate the summer solstice reversal of climate effects on European beech bud set

    This article has 9 authors:
    1. Dominic Rebindaine
    2. Thomas W Crowther
    3. Susanne S Renner
    4. Zhaofei Wu
    5. Yibiao Zou
    6. Lidong Mo
    7. Haozhi Ma
    8. Raymo Bucher
    9. Constantin M Zohner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This article presents valuable findings on how the timing of cooling affects the timing of autumn bud set in European beech saplings. The study leverages extensive experimental data and provides an interesting conceptual framework of the various ways in which warming can affect bud set timing. The support for the findings is incomplete, though extra justifications of the experimental settings, clarifications of the interpretation of the results, and alternative statistical analyses can make the conclusions more robust.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  18. Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

    This article has 12 authors:
    1. Jiho Park
    2. Grayson O Sipe
    3. Xin Tang
    4. Prachi Ojha
    5. Giselle Fernandes
    6. Yi Ning Leow
    7. Caroline Zhang
    8. Yuma Osako
    9. Arundhati Natesan
    10. Gabrielle T Drummond
    11. Rudolf Jaenisch
    12. Mriganka Sur
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    • Curated by eLife

      eLife Assessment

      In this manuscript, Park et al. developed a multiplexed CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 controls the processing of visual information. The findings are compelling, leveraging state-of-the-art gene CRISPR/Cas9, in vivo two-photon laser scanning microscopy, and advanced statistical modeling.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  19. PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

    This article has 17 authors:
    1. Shiyi Wang
    2. Ryan Baumert
    3. Gabrielle Séjourné
    4. Dhanesh Sivadasan Bindu
    5. Kylie Dimond
    6. Kristina Sakers
    7. Leslie Vazquez
    8. Jessica L Moore
    9. Christabel Xin Tan
    10. Tetsuya Takano
    11. Maria Pia Rodriguez
    12. Nick Brose
    13. Luke Bradley
    14. Reed Lessing
    15. Scott H Soderling
    16. Albert R La Spada
    17. Cagla Eroglu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The findings are convincing, as they rely on a comprehensive set of in vivo and in vitro genetic, biochemical, proteomic, and electrophysiological approaches. They are important because of their translational value, being validated in both mouse models and post-mortem human samples.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  20. Humans underestimate their body mass in microgravity: evidence from reaching movements during spaceflight

    This article has 8 authors:
    1. Zhaoran Zhang
    2. Yu Tian
    3. Chunhui Wang
    4. Changhua Jiang
    5. Bo Wang
    6. Hongqiang Yu
    7. Rui Zhao
    8. Kunlin Wei
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    • Curated by eLife

      eLife Assessment

      This paper undertakes an important investigation to determine whether movement slowing in microgravity is due to a strategic conservative approach or rather due to an underestimation of the mass of the arm. While the experimental dataset is unique and the coupled experimental and computational analyses comprehensive, the authors present incomplete results to support the claim that movement slowing is due to mass underestimation. Further analysis is needed to rule out alternative explanations.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity