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  1. A neural network model that generates salt concentration memory-dependent chemotaxis in Caenorhabditis elegans

    This article has 2 authors:
    1. Masakatsu Hironaka
    2. Tomonari Sumi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors utilize a valuable computational approach to exploring the mechanisms of memory-dependent klinotaxis, with a hypothesis that is both plausible and testable. Although they provide a solid hypothesis of circuit function based on an established model, the model's lack of integration of newer experimental findings, its reliance on predefined synaptic states, and oversimplified sensory dynamics, make the investigation incomplete for both memory and internal-state modulation of taxis.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation

    This article has 3 authors:
    1. Li He
    2. Jiayu Wen
    3. Qi Dai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory mechanisms both in vivo and in vitro. The work will be of broad interest to researchers working on growth factor signaling mechanisms and vertebrate development.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish

    This article has 11 authors:
    1. Oguzhan F Baltaci
    2. Andrea Usseglio Gaudi
    3. Stefanie Dudczig
    4. Weili Wang
    5. Maria Cristina Rondon-Galeano
    6. Ye-Wheen Lim
    7. James Rae
    8. Anne Lagendijk
    9. Robert G Parton
    10. Alison Farley
    11. Benjamin M Hogan
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    • Curated by eLife

      eLife Assessment

      This important study examines the role of pericytes in patterning the zebrafish blood-brain barrier (BBB) and controlling its permeability. Using pdgfrb mutant zebrafish models lacking brain pericytes, the authors report that pericyte-deficient cerebrovasculatures are ill-patterned, yet display unaltered restrictive BBB permeability properties at larval and juvenile stages. More severe phenotypes are detected in adults, with focal leakage sites associated with hemorrhages and aneurysms. Using solid and beautifully documented imaging, the authors suggest that, contrary to the situation described in rodent models, pdgfrb-dependent pericytes are not required to maintain the BBB in the zebrafish brain; these unexpected and intriguing findings reshape our understanding of BBB permeability regulation in vertebrates.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  4. Biophysical network modeling of temporal and stereotyped sequence propagation of neural activity in the premotor nucleus HVC

    This article has 3 authors:
    1. Zeina Bou Diab
    2. Marc Chammas
    3. Arij Daou
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    • Curated by eLife

      eLife Assessment

      Birdsong production depends on precise neural sequences in a vocal motor nucleus HVC. In this useful biophysical model, Daou and colleagues identify specific biophysical parameters that result in sparse neural sequences observed in vivo. While the model is presently incomplete because it is overfit to produce sequences and therefore not robust to real biological variation, the model has the potential to address some outstanding issues in HVC function.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Pupil dilation offers a time-window on prediction error

    This article has 4 authors:
    1. Olympia Colizoli
    2. Tessa van Leeuwen
    3. Danaja Rutar
    4. Harold Bekkering
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study seeks to examine the relationship between pupil size and information gain, showing opposite effects dependent upon whether the average uncertainty increases or decreases across trials. Given the broad implications for learning and perception, the findings will be of broad interest to researchers in cognitive neuroscience, decision-making, and computational modelling. Nevertheless, the evidence in support of the particular conclusion is at present incomplete - the conclusions would be strengthened if the authors could both clarify the differences between model-updating and prediction error in their account and clarify the patterns in the data.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. SATAY-Based Chemogenomic Screening uncovers Antifungal Resistance Mechanisms and Key Determinants of ATI-2307 and Chitosan Sensitivity

    This article has 7 authors:
    1. Matthew T. Karadzas
    2. Agnès H. Michel
    3. Andreas Mosbach
    4. George Giannakopoulos
    5. Ruairi McGettigan
    6. Gabriel Scalliet
    7. Benoît Kornmann
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    • Curated by eLife

      eLife Assessment

      This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing method in Saccharomyces cerevisiae. This method allows us to uncover loss- and gain-of-function mutations conferring resistance to 20 different antifungal compounds. The method is convincing, allowing the authors to identify a novel interaction of chitosan with the cell wall mannosylphosphate, and show that the transporter Hol1 concentrates the novel antifungal ATI-2307 within yeast.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

    This article has 10 authors:
    1. Joshua D Garcia
    2. Chenyu Wang
    3. Emmie Banks
    4. Timothy Fenton
    5. Jean-Marc DeKeyser
    6. Tatiana V Abramova
    7. Alfred L George
    8. Roy Ben-Shalom
    9. David H Hackos
    10. Kevin J Bender
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    • Curated by eLife

      eLife Assessment

      This manuscript presents a clever and powerful approach to examining differential roles of Nav1.2 and Nav1.6 channels in excitability of neocortical pyramidal neurons, by engineering mice in which a sulfonamide inhibitor of both channels has reduced affinity for one or the other channels. Overall, the results in the manuscript are compelling and give important information about differential roles of Nav1.6 and Nav1.2 channels. Activity-dependent inactivation of NaV1.6 was also found to attenuate seizure-like activity in cells, demonstrating the promise of activity-dependent NaV1.6-specific pharmacotherapy for epilepsy.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  8. Old age variably impacts chimpanzee engagement and efficiency in stone tool use

    This article has 7 authors:
    1. Elliot Howard-Spink
    2. Tetsuro Matsuzawa
    3. Susana Carvalho
    4. Catherine Hobaiter
    5. Katarina Almeida-Warren
    6. Thibaud Gruber
    7. Dora Biro
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study provides a novel framework for leveraging longitudinal field observations to examine the effects of aging on stone tool use behaviour in wild chimpanzees. However, the analysis and interpretation are currently incomplete and would benefit from a more robust consideration of additional sources of variance for the data (e.g., foraging ecology, nut and tool properties, etc.). Despite the low sample size of five individuals, this study is of broad interest to ethologists, primatologists, archaeologists, and psychologists.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

    This article has 8 authors:
    1. Aske L Ejdrup
    2. Jakob K Dreyer
    3. Matthew D Lycas
    4. Søren H Jørgensen
    5. Trevor W Robbins
    6. Jeffrey W Dalley
    7. Freja Herborg
    8. Ulrik Gether
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The conclusions of this work are based on valuable simulations of a detailed model of striatal dopamine dynamics. Establishing that a lower dopamine uptake rate can lead to a 'tonic' level of dopamine in the ventral but not dorsal striatum, and that dopamine concentration changes at short delays can be tracked by D1 but not D2 receptor activation, is of value and will be of interest to dopamine aficionados. However, the simulations are incomplete, providing only partial support for the key claims. Several things can be done to strengthen the conclusions, including, for example, but not exclusively, a demonstration of how the results would change as a function of changes in D2 affinity.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Human Brain-Wide Activation of Sleep Rhythms

    This article has 5 authors:
    1. Haiteng Wang
    2. Qihong Zou
    3. Jinbo Zhang
    4. Jia-Hong Gao
    5. Yunzhe Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study reports valuable findings from a very rich EEG-fMRI dataset including 107 participants, which was collected during nocturnal naps. The authors link activity in memory-related brain regions (e.g., hippocampus, thalamus, and medial prefrontal cortex), and their functional connectivity, to the occurrence of canonical sleep rhythms, namely spindles and slow oscillations in non-rapid eye movement sleep. This work could contribute to further understanding of sleep neural dynamics, although the evidence for some of the main claims is incomplete at present.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  11. The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

    This article has 8 authors:
    1. Ana Lapao
    2. Lauren Sophie Johnson
    3. Laura Trachsel-Moncho
    4. Sakshi Singh
    5. Matthew Yoke Wui Ng
    6. Sigve Nakken
    7. Eeva-Liisa Eskelinen
    8. Anne Simonsen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable insights into the role of two proteins, Rab27A and SYTL5, which control vesicle transport and delivery. While the data is clear, the overall evidence is somewhat incomplete. Strengthening the mechanistic aspect would enhance the study, making it of greater interest to cell biologists studying membrane trafficking and mitochondria.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  12. PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis

    This article has 24 authors:
    1. Hairui Su
    2. Yong Sun
    3. Han Guo
    4. Chiao-Wang Sun
    5. Qiuying Chen
    6. Szumam Liu
    7. Anlun Li
    8. Min Gao
    9. Rui Zhao
    10. Glen Raffel
    11. Jian Jin
    12. Cheng-qui Qu
    13. Michael Yu
    14. Christopher A Klug
    15. George Y Zheng
    16. Scott Ballinger
    17. Matthew Kutny
    18. XLong Zheng
    19. Zechen Chong
    20. Chamara Senevirathne
    21. Steve Gross
    22. Yabing Chen
    23. Minkui Luo
    24. Xinyang Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study reveals that PRMT1 overexpression drives tumorigenesis of acute megakaryocytic leukemia (AMKL) and that targeting PRMT1 is a viable approach for treating AMKL. While the evidence, based largely on one cell line, is convincing, further validations in additional experiment settings will solidify the conclusion. These findings have important implications for the treatment of AMKL with PRMT1 over expression in the future.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  13. A Commander-independent function of COMMD3 in endosomal trafficking

    This article has 5 authors:
    1. Galen T Squiers
    2. Chun Wan
    3. James Gorder
    4. Harrison Puscher
    5. Jingshi Shen
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    • Curated by eLife

      eLife Assessment

      This important study explores the commander-independent function of COMMD3-Arf1 in endosomal recycling. The evidence supporting the authors' claims is solid; however, the inclusion of additional validation experiments and control conditions would have further strengthened the study. The findings will be of significant interest to cell biologists working on membrane trafficking.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  14. Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

    This article has 10 authors:
    1. Francesco Marocco
    2. Sabrina Garbo
    3. Claudia Montaldo
    4. Alessio Colantoni
    5. Luca Quattrocchi
    6. Gioele Gaboardi
    7. Carla Cicchini
    8. Gian Gaetano Tartaglia
    9. Cecilia Battistelli
    10. Marco Tripodi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript makes a valuable contribution to the field by uncovering a molecular mechanism for miRNA intracellular retention, mediated by the interaction of PCBP2, SYNCRIP, and specific miRNA motifs. These findings advance our understanding of RNA-binding protein-mediated miRNA sorting and provide deeper insights into miRNA dynamics. While the conclusions are supported by solid experimental evidence, additional controls and clarification of the precise intracellular interactions would further strengthen the study.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  15. Newly discovered and conserved role of IgM against viral infection in an early vertebrate

    This article has 10 authors:
    1. Weiguang Kong
    2. Xinyou Wang
    3. Guangyi Ding
    4. Peng Yang
    5. Yong Shi
    6. Chang Cai
    7. Xinyi Yang
    8. Gaofeng Cheng
    9. Fumio Takizawa
    10. Zhen Xu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study explores the conserved role of IgM in both systemic and mucosal antiviral immunity in teleosts, challenging established views on the differential roles of IgT and IgM. The findings have theoretical and practical implications for immunology and aquaculture. However, the strength of the evidence is incomplete due to insufficient validation of the monoclonal antibodies used to deplete IgM, which limits confidence in the main claims. Addressing these methodological weaknesses would significantly enhance the study's impact.

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    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  16. Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation

    This article has 10 authors:
    1. Shiqiang Xu
    2. Alix Buridant
    3. Thibault Hirsch
    4. Massiullah Shafaq-Zadah
    5. Estelle Dransart
    6. Benjamin Ledoux
    7. Ludger Johannes
    8. Pierre van der Bruggen
    9. Pierre Morsomme
    10. Henri-François Renard
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study provides convincing evidence that specific proteins on the surface of cancer cells undergo a particular form of recycling and are redirected toward the cell-cell contact with T cells, a type of immune cell. However, the characterization of the consequences of T cell activation resulting from perturbing the recycling pathway is incomplete. Furthermore, relevant literature has not been sufficiently cited.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  17. Stability vs flexibility: reshaping archaeal membranes in silico

    This article has 5 authors:
    1. Miguel Amaral
    2. Felix Frey
    3. Xiuyun Jiang
    4. Buzz Baum
    5. Anđela Šarić
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study characterizes the mechanics and stability of bolalipids from archaeal membranes using molecular dynamics simulations. A mesoscale model of bolalipids is presented and evaluated across a series of membrane configurations. The evidence supporting the conclusions is convincing, demonstrating that mixtures of bolalipids and regular bilayer lipids in archaeal membranes enhance fluidity and stability.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  18. Neurons in the medial prefrontal cortex that are not modulated by hippocampal sharp-wave ripples are involved in spatial tuning and signaling upcoming choice

    This article has 2 authors:
    1. Hanna den Bakker
    2. Fabian Kloosterman
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    • Curated by eLife

      eLife Assessment

      This useful study reports analyses of Neuropixel recordings in the medial prefrontal cortex and hippocampus of rats in a spatial navigation trial, focusing on classifying prefrontal neurons based on SWR modulation and anatomical location. However, the evidence for claims of a clear link between SWR modulation and neuronal encoding, and the evidence for anatomical organization, is currently incomplete. Further analyses might strengthen the evidence for some conclusions, and some of the strong claims of the paper should likely be moderated.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  19. Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage Assisted Behavioral Innovation and Testing System

    This article has 6 authors:
    1. Bowen Yu
    2. Penghai Li
    3. Haoze Xu
    4. Yueming Wang
    5. Kedi Xu
    6. Yaoyao Hao
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    • Curated by eLife

      eLife Assessment

      This manuscript describes a novel approach for assessing cognitive function in freely moving mice in their home-cage, without human involvement. The authors provide convincing evidence in support of the tasks they developed to capture a variety of complex behaviors and demonstrate the utility of a machine learning approach to expedite the acquisition of task demands. This work is important given its potential utility for other investigators interested in studying mouse cognition. However, additional information (e.g., detailed construction manual, code) is needed to allow other investigators to implement this system independently and use it widely.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  20. Sexual Failure Decreases Sweet Taste Perception in Male Drosophila via Dopaminergic Signaling

    This article has 4 authors:
    1. Gaohang Wang
    2. Wei Qi
    3. Rui Huang
    4. Liming Wang
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    • Curated by eLife

      eLife Assessment

      This study provides valuable findings on the effects of mating experience on sweet taste perception. The data as presented provide solid evidence that the dopaminergic signaling-mediated reward system underlies this mating state-dependent behavioral modulation. The work will interest neuroscientists, particularly those working on neuromodulation and the effects of internal states on behavior.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity