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10.1101/2025.08.14.670329
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10.64898/2026.06.10.731153
Persistent Microglial HIV Infection Drives Neuroinflammation Despite Viral Suppression: Insights from Rapid Postmortem Brain Biopsies

This article has 19 authors:
1. M. Nühn Marieke
2. Nadia Sabet
3. Nanouk Zuidmeer
4. C.J. van Abeelen Kirsten
5. E. Hermans Lucas
6. J. Schipper Pauline
7. Raphael Kübler
8. E. Basson Adriaan
9. Tanvier Omar
10. Ebrahim Variava
11. A. Martinson Neil
12. Stefanie Giacopazzi
13. D. F. Venter Willem
14. J. Muraro Mauro
15. M. J. Wensing Annemarie
16. D. de Witte Lot
17. A. Papathanasopoulos Maria
18. Monique Nijhuis
19. Jori Symons
This article has been curated by 1 group:
- Curated by eLife
  
  eLife Assessment
  
  This is a valuable study that contributes to our understanding of transcriptomic responses in microglia to HIV infection in the human brain. The evidence provided remains incomplete, and further analyses are required (i.e., a bigger sample size) to eliminate confounding factors so that the study can unequivocally ascertain the persistent inflammatory state of microglia in HIV-suppressed brains.
Reviewed by eLife

This article has 3 evaluationsAppears in 1 listLatest version May 25, 2026Latest activity Sep 1, 2026
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