Evaluated articles

A list by eLife

Articles that have been evaluated by eLife.

8259 articlesLast updated

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  3. Freshwater monitoring by nanopore sequencing

    1. Lara Urban
    2. Andre Holzer
    3. J Jotautas Baronas
    4. Michael B Hall
    5. Philipp Braeuninger-Weimer
    6. Michael J Scherm
    7. Daniel J Kunz
    8. Surangi N Perera
    9. Daniel E Martin-Herranz
    10. Edward T Tipper
    11. Susannah J Salter
    12. Maximilian R Stammnitz

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy

    1. Johanna S. Jackson
    2. James D. Johnson
    3. Soraya Meftah
    4. Tracey K Murray
    5. Zeshan Ahmed
    6. Matteo Fasiolo
    7. Michael L. Hutton
    8. John T.R. Isaac
    9. Michael J. O’Neill
    10. Michael C. Ashby

    • Curated by eLife

      Summary: This paper describes studies of a mouse model of tauopathy with relevance to Alzheimer's Disease. A powerful approach of longitudinal imaging of single synaptic structures over time allows insights into the time course of progressive neurogenerative responses. The strengths of the report are the relevance of the question to human disease, the powerful imaging approach, and the indication that there may be a programmed sequence of structural changes that mediate tauopathy. On the other hand, there were multiple issues with the transgenic mouse model used, which would seriously limit interpretation of results without suitable controls. Further, the data set appeared to be quite noisy, and variable between animals, which may result in part from the nonspecific methods of expressing fluorescent markers, thus leading to uncertainty regarding the specific identity of pre- and post-synaptic elements.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. A computationally designed fluorescent biosensor for D-serine

    1. Vanessa Vongsouthi
    2. Jason H. Whitfield
    3. Petr Unichenko
    4. Joshua A. Mitchell
    5. Björn Breithausen
    6. Olga Khersonsky
    7. Leon Kremers
    8. Harald Janovjak
    9. Hiromu Monai
    10. Hajime Hirase
    11. Sarel J. Fleishman
    12. Christian Henneberger
    13. Colin J. Jackson

    • Curated by eLife

      Summary: The reviewers recognize the merits of your work and your efforts to engineer a D-serine selective biosensor. However, they also raise major concerns regarding the experimental design (selection of mutations), methodology and achieved applicability. The reviewers find that the improvement in the selectivity of the engineered construct for the targeted ligand over alternative ligands is modest. They further indicate ambiguities regarding the origin of the ligand-induced fluorescence signal changes of the sensor. Other problematic aspects are the estimation of thermal stabilities and the lack of physiological signals in fluorescence imaging results that could demonstrate applicability to a biological problem.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. Linking minimal and detailed models of CA1 microcircuits reveals how theta rhythms emerge and their frequencies controlled

    1. Alexandra Pierri Chatzikalymniou
    2. Melisa Gumus
    3. Frances K. Skinner

    • Curated by eLife

      Summary: This study tackles a difficult problem of understanding the basis for hippocampal theta rhythms through reduction of a highly detailed model, seeking to validate a reduced model that would be more amenable to analysis. The reviewers appreciated the attention to this challenging problem and the substantial work that went into it, but had several fundamental concerns about the methodology, interpretation, and reporting.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  9. Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

    1. Melissa J Polonenko
    2. Ross K Maddox

    • Curated by eLife

      Summary: This manuscript describes a type of alteration to speech to make it more peaky, with the goal of inducing stronger responses in the auditory brainstem. Recent work has employed naturalistic speech to investigate subcortical mechanisms of speech processing. However, previous methods were ill equipped to tease apart the neural responses in different parts of the brainstem. The authors show that their speech manipulation improves this: the peaky speech that they develop allows to segregate different waves of the brainstem response. This development may allow further and more refined investigations of the contribution of different parts of the brainstem to speech processing, as well as to hearing deficits.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution

    1. M. J. Higgs
    2. M. J. Hill
    3. R. M. John
    4. A. R. Isles

    • Curated by eLife

      Summary: The reviewers appreciated the effort to merge most of the available datasets to make a precise survey of the sites of imprinted gene expression and the great resource it could bring to the community. However, the reviewers also felt that the study suffered from methodological bias, was preliminary (no allelic information in particular), and that the conclusions did not go beyond previous reports. The general lack of citation of the name of imprinted genes made it difficult to judge whether conclusions were consistent among the different datasets. Highlighting specific imprinted genes would bring a clearer focus and narrative.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  11. Brain network reconfiguration for narrative and argumentative thought

    1. Yangwen Xu
    2. Lorenzo Vignali
    3. Olivier Collignon
    4. Davide Crepaldi
    5. Roberto Bottini

    • Curated by eLife

      Summary: The reviewers thought this was a nicely written paper, and were interested in the idea of extending intersubject correlation (ISC) and intersubject functional connectivity (ISFC) work on narratives to arguments. One major concern was that effects reported here may be driven in part by the scrambled conditions. Specifically, the scrambled argument seems to have resulted in stronger and more widespread ISC than the intact argument: this would call into question assumptions about the scrambled version being a control condition. Another, related concern raised is that perhaps argumentative texts are very different from narrative texts: perhaps argumentative texts are less structured, or less interesting (?) and this is why the intact and scrambled versions are so similar. Together with other issues, relating to the interpretation of the findings, it was felt that while of interest, the study's major conclusions could not be justified without additional experiments.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  17. Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses

    1. Juan Jose Rodriguez Gotor
    2. Kashif Mahfooz
    3. Isabel Perez-Otano
    4. John F Wesseling

    • Curated by eLife

      eLife assessment

      This study addresses the long-standing question as to how different functional pools of synaptic vesicles are organized in presynaptic terminals to mediate different modes of neurotransmitter release. Based on imaging of active synapses with recycling synaptic vesicles labeled by FM-styryl dyes, the authors provide data that are compatible with the hypothesis that two separate reserve pools of vesicles – slowly vs. rapidly mobilizing – feed two distinct releasable pools – reluctantly vs. rapidly releasing. Overall, this study represents a valuable contribution to the field of synapse biology, specifically to presynaptic dynamics and plasticity. The authors' methodological approach of using bulk FM-styryl dye destaining as a readout of precise vesicle arrangements and pools in a population of functionally very diverse synapses has limitations. Consequently, the evidence that directly supports the authors' two-pool-interpretation of their data is incomplete, and alternative interpretations of the data remain possible.

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity
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