Evaluated articles

A list by eLife

Articles that have been evaluated by eLife.

8650 articlesLast updated

Related articles (Labs 🧪)

Showing page 1 of 433

  1. IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2

    1. John P. Miller
    2. Kyu Kwang Kim
    3. Cameron WA Snyder
    4. Negar Khazan
    5. Niloy A. Singh
    6. Megan E. Boyer
    7. Elizabeth Lamere
    8. Myla Strawderman
    9. Sonali Sharma
    10. Ronald Lakony
    11. Michelle Whittum
    12. Mark Anderson
    13. Rick Keenan
    14. Elizabeth Pritchett
    15. Cameron Baker
    16. John Ashton
    17. Manoj K. Khera
    18. Michael R. Elliott
    19. Christina M. Annunziata
    20. Jeevisha Bajaj
    21. Laura M. Calvi
    22. Michael W. Becker
    23. Rachael Rowswell-Turner
    24. Richard G. Moore
    25. Rakesh K. Singh

    • Curated by eLife

      eLife Assessment

      This valuable study identifies the IL1R1-IRAK4 axis as a mediator of inflammation-associated ovarian cancer implantation. The evidence is convincing, supported by complementary genetic and pharmacological approaches across multiple in vivo models. These findings advance our understanding of how inflammatory signaling shapes metastatic niche formation and highlight IRAK4 as a potential therapeutic target.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Focused ultrasound alters neural time irreversibility independently of response amplitude

    1. Jacek P. Dmochowski
    2. David H. Wolpert

    • Curated by eLife

      eLife Assessment

      This study presents a useful approach to analyzing brain responses to transcranial focused ultrasound (tFUS), and potentially to neuromodulation-evoked activity more generally. By applying ideas from physics, it reveals changes in brain activity that measures of signal strength alone do not capture. The authors report a surprising non-monotonic relationship between irreversibility and stimulation dose, and a relationship between baseline irreversibility and susceptibility during stimulation. The evidence for the central interpretation remains incomplete, however: it is not yet clear that these changes reflect genuine reorganization of brain activity rather than artifacts of the calcium-recording method or an unaccounted-for side effect of the stimulation itself.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  17. Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity

    1. Shaoyu Tu
    2. Yue Du
    3. Wei Liang
    4. Xiaoyi Xu
    5. Jiahui Zou
    6. Yuchao Yang
    7. Chuhan Xiong
    8. Yanglin Li
    9. Meijun Jiang
    10. Aotian Ouyang
    11. Tong Chen
    12. Meilin Jin
    13. Huanchun Chen
    14. Hongbo Zhou

    • Curated by eLife

      eLife Assessment

      This valuable study reveals a role for lactylation in influenza polymerase function and virus replication. The evidence supporting the claims is solid, although the direct involvement of ATAT1 and SIRT1 in this modification and the functional relevance of the identified sites can be further substantiated. These findings will appeal broadly to influenza virologists studying polymerase regulation, as well as researchers investigating the functional roles of lactylation.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
Next