Showing page 414 of 1181 pages of list content

  1. Protein Arginylation Is Regulated during SARS-CoV-2 Infection

    This article has 15 authors:
    1. Janaina Macedo-da-Silva
    2. Livia Rosa-Fernandes
    3. Vinicius de Morais Gomes
    4. Veronica Feijoli Santiago
    5. Deivid Martins Santos
    6. Catarina Maria Stanischesk Molnar
    7. Bruno Rafael Barboza
    8. Edmarcia Elisa de Souza
    9. Rodolfo Ferreira Marques
    10. Silvia Beatriz Boscardin
    11. Edison Luiz Durigon
    12. Claudio Romero Farias Marinho
    13. Carsten Wrenger
    14. Suely Kazue Nagahashi Marie
    15. Giuseppe Palmisano

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

    This article has 9 authors:
    1. Mohammad Afsar
    2. Rohan Narayan
    3. Md Noor Akhtar
    4. Deepakash Das
    5. Huma Rahil
    6. Santhosh Kambaiah Nagaraj
    7. Sandeep M Eswarappa
    8. Shashank Tripathi
    9. Tanweer Hussain
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This work reports on a drug repurposing effort to target the non-structural protein 1 (Nsp1) of SARS-Cov-2, involved in suppressing host immune function. The authors use a combination of computational, in vitro and cellular assays to this end. They start by virtual screening of an FDA approved drug library, followed by biophysical assays to measure the binding affinity of the top hits as well as molecular dynamics simulations and free energy calculations to confirm binding poses. Finally, in vitro and cellular assays were used to quantify translation inhibition and rescue as well as the production of infectious virus particles. One of the FDA approved drugs, Montelukast, emerges as a promising antiviral drug candidate.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    This article has 5 evaluationsAppears in 3 listsLatest version Latest activity
  3. Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2

    This article has 22 authors:
    1. Irene P. Chen
    2. James E. Longbotham
    3. Sarah McMahon
    4. Rahul K. Suryawanshi
    5. Mir M. Khalid
    6. Taha Y. Taha
    7. Takako Tabata
    8. Jennifer M. Hayashi
    9. Frank W. Soveg
    10. Jared Carlson-Stevermer
    11. Meghna Gupta
    12. Meng Yao Zhang
    13. Victor L. Lam
    14. Yang Li
    15. Zanlin Yu
    16. Erron W. Titus
    17. Amy Diallo
    18. Jennifer Oki
    19. Kevin Holden
    20. Nevan Krogan
    21. Danica Galonić Fujimori
    22. Melanie Ott

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

    This article has 17 authors:
    1. Rana Abdelnabi
    2. Caroline S. Foo
    3. Dirk Jochmans
    4. Laura Vangeel
    5. Steven De Jonghe
    6. Patrick Augustijns
    7. Raf Mols
    8. Birgit Weynand
    9. Thanaporn Wattanakul
    10. Richard M. Hoglund
    11. Joel Tarning
    12. Charles E. Mowbray
    13. Peter Sjö
    14. Fanny Escudié
    15. Ivan Scandale
    16. Eric Chatelain
    17. Johan Neyts

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

    This article has 36 authors:
    1. Junyu Chen
    2. Pui Wang
    3. Lunzhi Yuan
    4. Liang Zhang
    5. Limin Zhang
    6. Hui Zhao
    7. Congjie Chen
    8. Xijing Wang
    9. Jinle Han
    10. Yaode Chen
    11. Jizong Jia
    12. Zhen Lu
    13. Junping Hong
    14. Zicen Lu
    15. Qian Wang
    16. Rirong Chen
    17. Ruoyao Qi
    18. Jian Ma
    19. Min Zhou
    20. Huan Yu
    21. Chunlan Zhuang
    22. Xiaohui Liu
    23. Qiangyuan Han
    24. Guosong Wang
    25. Yingying Su
    26. Quan Yuan
    27. Tong Cheng
    28. Ting Wu
    29. Xiangzhong Ye
    30. Tianying Zhang
    31. Changgui Li
    32. Jun Zhang
    33. Huachen Zhu
    34. Yixin Chen
    35. Honglin Chen
    36. Ningshao Xia

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Excessive inflammatory and metabolic responses to acute SARS-CoV-2 infection are associated with a distinct gut microbiota composition

    This article has 21 authors:
    1. Werner C. Albrich
    2. Tarini Shankar Ghosh
    3. Sinead Ahearn-Ford
    4. Flora Mikaeloff
    5. Nonhlanhla Lunjani
    6. Brian Forde
    7. Noémie Suh
    8. Gian-Reto Kleger
    9. Urs Pietsch
    10. Manuel Frischknecht
    11. Christian Garzoni
    12. Rossella Forlenza
    13. Mary Horgan
    14. Corinna Sadlier
    15. Tommaso Rochat Negro
    16. Jérôme Pugin
    17. Hannah Wozniak
    18. Andreas Cerny
    19. Ujjwal Neogi
    20. Paul W. O’Toole
    21. Liam O’Mahony

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. COVID-19 first and delta waves in relation to ACEI, ARB, Influenza vaccination, and comorbidity in a North Metropolitan Barcelona Health Consortium

    This article has 11 authors:
    1. Marta Juanes-González
    2. Ana Calderón-Valdiviezo
    3. Helena Losa-Puig
    4. Roger Valls-Foix
    5. Marta González-Salvador
    6. Marc León-Pérez
    7. Luís Pueyo-Antón
    8. Celia Lozano-Paz
    9. Maite Franco-Romero
    10. Josep Vidal-Alaball
    11. Anna Puigdellívol-Sánchez

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. A Booster Dose of CoronaVac Increases Neutralizing Antibodies and T Cells that Recognize Delta and Omicron Variants of Concern

    This article has 39 authors:
    1. Bárbara M. Schultz
    2. Felipe Melo-González
    3. Luisa F. Duarte
    4. Nicolás M. S. Gálvez
    5. Gaspar A. Pacheco
    6. Jorge A. Soto
    7. Roslye V. Berríos-Rojas
    8. Liliana A. González
    9. Daniela Moreno-Tapia
    10. Daniela Rivera-Pérez
    11. Mariana Ríos
    12. Yaneisi Vázquez
    13. Guillermo Hoppe-Elsholz
    14. Catalina A. Andrade-Parra
    15. Omar P. Vallejos
    16. Alejandro Piña-Iturbe
    17. Carolina Iturriaga
    18. Marcela Urzua
    19. María S. Navarrete
    20. Álvaro Rojas
    21. Rodrigo Fasce
    22. Jorge Fernández
    23. Judith Mora
    24. Eugenio Ramírez
    25. Aracelly Gaete-Argel
    26. Mónica L. Acevedo
    27. Fernando Valiente-Echeverría
    28. Ricardo Soto-Rifo
    29. Daniela Weiskopf
    30. Alba Grifoni
    31. Alessandro Sette
    32. Gang Zeng
    33. Weining Meng
    34. CoronaVac03CL Study Group
    35. José V. González-Aramundiz
    36. Pablo A. González
    37. Katia Abarca
    38. Alexis M. Kalergis
    39. Susan M. Bueno

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant

    This article has 19 authors:
    1. Natasha N. Gaudreault
    2. Konner Cool
    3. Jessie D. Trujillo
    4. Igor Morozov
    5. David A. Meekins
    6. Chester McDowell
    7. Dashzeveg Bold
    8. Mariano Carossino
    9. Velmurugan Balaraman
    10. Dana Mitzel
    11. Taeyong Kwon
    12. Daniel W. Madden
    13. Bianca Libanori Artiaga
    14. Roman M. Pogranichniy
    15. Gleyder Roman-Sosa
    16. William C. Wilson
    17. Udeni B. R. Balasuriya
    18. Adolfo García-Sastre
    19. Juergen A. Richt

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Care Models for Long COVID : A Rapid Systematic Review

    This article has 11 authors:
    1. Simon Décary
    2. Michèle Dugas
    3. Théo Stefan
    4. Léa Langlois
    5. Becky Skidmore
    6. Anne Bhéreur
    7. Annie LeBlanc
    8. Alberta Health Services
    9. Stephanie Hastings
    10. Branden Manns
    11. Lynora Saxinger

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity