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  1. SARS‐CoV ‐2 antibody persistence in COVID ‐19 convalescent plasma donors: Dependency on assay format and applicability to serosurveillance

    This article has 18 authors:
    1. Clara Di Germanio
    2. Graham Simmons
    3. Kathleen Kelly
    4. Rachel Martinelli
    5. Orsolya Darst
    6. Mahzad Azimpouran
    7. Mars Stone
    8. Kelsey Hazegh
    9. Eduard Grebe
    10. Shuting Zhang
    11. Peijun Ma
    12. Marek Orzechowski
    13. James E. Gomez
    14. Jonathan Livny
    15. Deborah T. Hung
    16. Ralph Vassallo
    17. Michael P. Busch
    18. Larry J. Dumont

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  2. Infection and transmission of SARS-CoV-2 depends on heparan sulfate proteoglycans

    This article has 16 authors:
    1. Marta Bermejo-Jambrina
    2. Julia Eder
    3. Tanja M. Kaptein
    4. John L. van Hamme
    5. Leanne C. Helgers
    6. Killian E. Vlaming
    7. Philip J.M. Brouwer
    8. Alexander P.J. Vlaar
    9. Frank E.H.P. van Baarle
    10. Marcel Spaargaren
    11. Godelieve J. de Bree
    12. Bernadien M. Nijmeijer
    13. Neeltje A. Kootstra
    14. Marit J. van Gils
    15. Rogier W. Sanders
    16. Teunis B. H. Geijtenbeek

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  3. Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

    This article has 31 authors:
    1. Maritza Puray-Chavez
    2. Kyle M. LaPak
    3. Travis P. Schrank
    4. Jennifer L. Elliott
    5. Dhaval P. Bhatt
    6. Megan J. Agajanian
    7. Ria Jasuja
    8. Dana Q. Lawson
    9. Keanu Davis
    10. Paul W. Rothlauf
    11. Zhuoming Liu
    12. Heejoon Jo
    13. Nakyung Lee
    14. Kasyap Tenneti
    15. Jenna E. Eschbach
    16. Christian Shema Mugisha
    17. Emily M. Cousins
    18. Erica W. Cloer
    19. Hung R. Vuong
    20. Laura A. VanBlargan
    21. Adam L. Bailey
    22. Pavlo Gilchuk
    23. James E. Crowe
    24. Michael S. Diamond
    25. D. Neil Hayes
    26. Sean P.J. Whelan
    27. Amjad Horani
    28. Steven L. Brody
    29. Dennis Goldfarb
    30. M. Ben Major
    31. Sebla B. Kutluay

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  4. A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

    This article has 18 authors:
    1. Leo Hanke
    2. Hrishikesh Das
    3. Daniel J. Sheward
    4. Laura Perez Vidakovics
    5. Egon Urgard
    6. Ainhoa Moliner-Morro
    7. Changil Kim
    8. Vivien Karl
    9. Alec Pankow
    10. Natalie L. Smith
    11. Bartlomiej Porebski
    12. Oscar Fernandez-Capetillo
    13. Erdinc Sezgin
    14. Gabriel K. Pedersen
    15. Jonathan M. Coquet
    16. B. Martin HĂ€llberg
    17. Ben Murrell
    18. Gerald M. McInerney

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  5. SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-ÎșB pathway

    This article has 6 authors:
    1. Shahanshah Khan
    2. Mahnoush S Shafiei
    3. Christopher Longoria
    4. John W Schoggins
    5. Rashmin C Savani
    6. Hasan Zaki
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The identification of a novel role of the spike protein expressed on SARS-CoV-2 in directly evoking the host inflammatory responses has a substantial impact in understanding the molecular mechanism of COVID-19 pathogenesis, which may have implication for development of new therapeutics. The elegant analytic approach conducted herein justifies the major conclusions of this work though several additional steps can be made to validate these claims.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    This article has 6 evaluationsAppears in 4 listsLatest version Latest activity
  6. North American deer mice are susceptible to SARS-CoV-2

    This article has 28 authors:
    1. Bryan D. Griffin
    2. Mable Chan
    3. Nikesh Tailor
    4. Emelissa J. Mendoza
    5. Anders Leung
    6. Bryce M. Warner
    7. Ana T. Duggan
    8. Estella Moffat
    9. Shihua He
    10. Lauren Garnett
    11. Kaylie N. Tran
    12. Logan Banadyga
    13. Alixandra Albietz
    14. Kevin Tierney
    15. Jonathan Audet
    16. Alexander Bello
    17. Robert Vendramelli
    18. Amrit S. Boese
    19. Lisa Fernando
    20. L. Robbin Lindsay
    21. Claire M. Jardine
    22. Heidi Wood
    23. Guillaume Poliquin
    24. James E. Strong
    25. Michael Drebot
    26. David Safronetz
    27. Carissa Embury-Hyatt
    28. Darwyn Kobasa

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  7. A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses

    This article has 35 authors:
    1. Alexandra Tauzin
    2. Manon Nayrac
    3. Mehdi Benlarbi
    4. Shang Yu Gong
    5. Romain Gasser
    6. Guillaume Beaudoin-BussiĂšres
    7. Nathalie Brassard
    8. Annemarie Laumaea
    9. Dani Vézina
    10. Jérémie Prévost
    11. Sai Priya Anand
    12. Catherine Bourassa
    13. Gabrielle Gendron-Lepage
    14. Halima Medjahed
    15. Guillaume Goyette
    16. Julia Niessl
    17. Olivier Tastet
    18. Laurie Gokool
    19. Chantal Morrisseau
    20. Pascale Arlotto
    21. Leonidas Stamatatos
    22. Andrew T. McGuire
    23. Catherine Larochelle
    24. Pradeep Uchil
    25. Maolin Lu
    26. Walther Mothes
    27. Gaston De Serres
    28. Sandrine Moreira
    29. Michel Roger
    30. Jonathan Richard
    31. Valérie Martel-LaferriÚre
    32. Ralf Duerr
    33. Cécile Tremblay
    34. Daniel E. Kaufmann
    35. Andrés Finzi

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  8. Risks of covid-19 hospital admission and death for people with learning disability: population based cohort study using the OpenSAFELY platform

    This article has 36 authors:
    1. Elizabeth J Williamson
    2. Helen I McDonald
    3. Krishnan Bhaskaran
    4. Alex J Walker
    5. Sebastian Bacon
    6. Simon Davy
    7. Anna Schultze
    8. Laurie Tomlinson
    9. Chris Bates
    10. Mary Ramsay
    11. Helen J Curtis
    12. Harriet Forbes
    13. Kevin Wing
    14. Caroline Minassian
    15. John Tazare
    16. Caroline E Morton
    17. Emily Nightingale
    18. Amir Mehrkar
    19. Dave Evans
    20. Peter Inglesby
    21. Brian MacKenna
    22. Jonathan Cockburn
    23. Christopher T Rentsch
    24. Rohini Mathur
    25. Angel Y S Wong
    26. Rosalind M Eggo
    27. William Hulme
    28. Richard Croker
    29. John Parry
    30. Frank Hester
    31. Sam Harper
    32. Ian J Douglas
    33. Stephen J W Evans
    34. Liam Smeeth
    35. Ben Goldacre
    36. Hannah Kuper

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  9. Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

    This article has 29 authors:
    1. Fred D Mast
    2. Peter C Fridy
    3. Natalia E Ketaren
    4. Junjie Wang
    5. Erica Y Jacobs
    6. Jean Paul Olivier
    7. Tanmoy Sanyal
    8. Kelly R Molloy
    9. Fabian Schmidt
    10. Magdalena Rutkowska
    11. Yiska Weisblum
    12. Lucille M Rich
    13. Elizabeth R Vanderwall
    14. Nicholas Dambrauskas
    15. Vladimir Vigdorovich
    16. Sarah Keegan
    17. Jacob B Jiler
    18. Milana E Stein
    19. Paul Dominic B Olinares
    20. Louis Herlands
    21. Theodora Hatziioannou
    22. D Noah Sather
    23. Jason S Debley
    24. David Fenyö
    25. Andrej Sali
    26. Paul D Bieniasz
    27. John D Aitchison
    28. Brian T Chait
    29. Michael P Rout
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The manuscript by Mast et al. describes an impressive collection of new nanobodies against SARS-CoV-2 spike, which probably provides the most complete coverage of the accessible epitopes of spike to date. The authors thoroughly characterize biophysical and functional properties of the nanobodies and set an example of how to best combine multiple nanobodies to target a pathogen. As the latest in a long series of SARS-CoV-2 nanobody papers, this study stands out for its completeness, although it does not provide a novel mechanism of action or biological insights.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    This article has 6 evaluationsAppears in 2 listsLatest version Latest activity