Evaluated articles

Fusion with heat-resistant obscure (Hero) proteins have the potential to improve the molecular property of recombinant proteins

1. Eri Morimoto
2. Kotaro Tsuboyama
3. Yukihide Tomari

Reviewed by ASAPbio crowd review

The kinetic landscape of human transcription factors

1. Nicholas E Mamrak
2. Nader Alerasool
3. Daniel Griffith
4. Alex S Holehouse
5. Mikko Taipale
6. Timothée Lionnet

Reviewed by ASAPbio crowd review

Translational Activity Controls Ribophagic Flux and Turnover of Distinct Ribosome Pools

1. Jakob Trendel
2. Milan Aleksić
3. Matilde Bertolini
4. Marco Jochem
5. Günter Kramer
6. Stefan Pfeffer
7. Bernd Bukau
8. Jeroen Krijgsveld

Reviewed by ASAPbio crowd review

Increasing protein stability by inferring substitution effects from high-throughput experiments

1. Rasmus Krogh Norrild
2. Kristoffer Enøe Johansson
3. Charlotte O’Shea
4. Jens Preben Morth
5. Kresten Lindorff-Larsen
6. Jakob Rahr Winther

Reviewed by ASAPbio crowd review

Confined migration induces heterochromatin formation and alters chromatin accessibility

1. Chieh-Ren Hsia
2. Jawuanna McAllister
3. Ovais Hasan
4. Julius Judd
5. Seoyeon Lee
6. Richa Agrawal
7. Chao-Yuan Chang
8. Paul Soloway
9. Jan Lammerding

Reviewed by ASAPbio crowd review

CHIP ubiquitin ligase is involved in the nucleolar stress management

1. Malgorzata Piechota
2. Lilla Biriczova
3. Konrad Kowalski
4. Natalia A. Szulc
5. Wojciech Pokrzywa

Reviewed by ASAPbio crowd review

ERK pathway activation inhibits ciliogenesis and causes defects in motor behavior, ciliary gating, and cytoskeletal rearrangement

1. Larissa L Dougherty
2. Soumita Dutta
3. Prachee Avasthi

Reviewed by Review Commons, ASAPbio crowd review

Load adaptation of endocytic actin networks

1. Charlotte Kaplan
2. Sam J. Kenny
3. Xuyan Chen
4. Johannes Schöneberg
5. Ewa Sitarska
6. Alba Diz-Muñoz
7. Matthew Akamatsu
8. Ke Xu
9. David G. Drubin

Reviewed by ASAPbio crowd review

RBBP6 activates the pre-mRNA 3′ end processing machinery in humans

1. Vytaute Boreikaite
2. Thomas S. Elliott
3. Jason W. Chin
4. Lori A. Passmore

Reviewed by ASAPbio crowd review

The extracellular matrix supports cancer cell growth under amino acid starvation by promoting tyrosine catabolism

1. Mona Nazemi
2. Bian Yanes
3. Montserrat Llanses Martinez
4. Heather Walker
5. Frederic Bard
6. Elena Rainero

Reviewed by Review Commons, ASAPbio crowd review

Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation

1. Anand P. Singh
2. Ping Wu
3. Sergey Ryabichko
4. João Raimundo
5. Michael Swan
6. Eric Wieschaus
7. Thomas Gregor
8. Jared E. Toettcher

Reviewed by ASAPbio crowd review

Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation

1. Margarida Dantas
2. Andreia Oliveira
3. Paulo Aguiar
4. Helder Maiato
5. Jorge G. Ferreira

Reviewed by Review Commons, ASAPbio crowd review

Optogenetic control of NOTCH1 signaling

1. Joanna Kałafut
2. Jakub Czapiński
3. Alicja Przybyszewska-Podstawka
4. Arkadiusz Czerwonka
5. Adrian Odrzywolski
6. Cecilia Sahlgren
7. Adolfo Rivero-Müller

Reviewed by ASAPbio crowd review

Exploring functional protein covariation across single cells using nPOP

1. Andrew Leduc
2. R. Gray Huffman
3. Joshua Cantlon
4. Saad Khan
5. Nikolai Slavov

Reviewed by ASAPbio crowd review

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

1. Alex F Thompson
2. Patrick R Blackburn
3. Noah S Arons
4. Sarah N Stevens
5. Dusica Babovic-Vuksanovic
6. Jane B Lian
7. Eric W Klee
8. Jason Stumpff

Reviewed by ASAPbio crowd review

mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes

1. Kun Leng
2. Brendan Rooney
3. Frank McCarthy
4. Wenlong Xia
5. Indigo V.L. Rose
6. Sophie Bax
7. Marcus Chin
8. Saeed Fathi
9. Kari A. Herrington
10. Manuel Leonetti
11. Aimee Kao
12. Stephen P.J. Fancy
13. Joshua E. Elias
14. Martin Kampmann

Reviewed by ASAPbio crowd review

Visualizing molecules of functional human profilin

1. Morgan L Pimm
2. Xinbei Liu
3. Farzana Tuli
4. Jennifer Heritz
5. Ashley Lojko
6. Jessica L Henty-Ridilla

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to a broad audience of cell biologists and biochemists who study the cytoskeleton. It reports the development and rigorous characterization of a fully functional, fluorescently labeled version of profilin that can be used to visualize profilin's dynamic interactions in live cells. Owing to profilin's dual functions in regulating actin and microtubule assembly, this technological development will be a useful tool for a wide range of studies aimed at understanding the role of the cytoskeleton in driving fundamental cellular processes.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife, ASAPbio crowd review

Local regulation of extracellular vesicle traffic by the synaptic endocytic machinery

1. Cassandra R. Blanchette
2. Amy L. Scalera
3. Kathryn P. Harris
4. Zechuan Zhao
5. Erica C. Dresselhaus
6. Kate Koles
7. Anna Yeh
8. Julia K. Apiki
9. Bryan A. Stewart
10. Avital A. Rodal

Reviewed by ASAPbio crowd review

Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe

1. Joseph M Varberg
2. Jay R Unruh
3. Andrew J Bestul
4. Azqa A Khan
5. Sue L Jaspersen

Reviewed by ASAPbio crowd review

Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B

1. Manuel Lera-Ramirez
2. François J Nédélec
3. Phong T Tran

• Curated by eLife

  Evaluation Summary:

  This study carefully quantifies microtubule dynamics during anaphase in the fission yeast S. pombe. The high quality data revealed two new observations: that microtubule rescue occurs preferentially at the edge of the midzone and that microtubule growth speed decreases when the nuclear membrane wraps around the spindle midzone in late anaphase. This sheds new light on the interplay between the nuclear membrane and the midspindle in closed mitosis, and the study will be of interest to cell biologists studying spindle dynamics and mitosis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by ASAPbio crowd review, eLife