@fatemehkhalili's saved articles

A list by Fatemeh Khalili

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  2. Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

    1. Xiaoxuan Lin
    2. Patrick R Haller
    3. Navid Bavi
    4. Nabil Faruk
    5. Eduardo Perozo
    6. Tobin R Sosnick

    • Curated by eLife

      eLife assessment

      This study presents important findings regarding the local dynamics at the anion binding site in the SLC26 transporter prestin that is responsible for electromotility in outer hair cells. The authors reveal critical differences to homologous proteins and thereby provide insight into prestin's unique function. The evidence is generally convincing, although orthogonal evidence would be required to fully support the claims concerning the mechanistic basis for voltage sensitivity.

    Reviewed by eLife

    13 evaluationsAppears in 3 listsLatest version Latest activity

  4. How accurately can one predict drug binding modes using AlphaFold models?

    1. Masha Karelina
    2. Joseph J Noh
    3. Ron O Dror

    • Curated by eLife

      eLife assessment

      This important study presents findings with broad implications for the use of AlphaFold2 models in ligand binding pose modeling, a common task in protein structure modeling. The computational experiments and analyses provide compelling results for the GPCR protein family data, but the conclusions are likely to apply also to other proteins and they will therefore be of interest to biophysicists, physical chemists, structural biologists, and anyone interested or involved in structure-based ligand discovery.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity