@kenton_swartz's saved articles

A list by Kenton Swartz

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  10. Keratinocyte PIEZO1 modulates cutaneous mechanosensation

    1. Alexander R Mikesell
    2. Olena Isaeva
    3. Francie Moehring
    4. Katelyn E Sadler
    5. Anthony D Menzel
    6. Cheryl L Stucky

    • Curated by eLife

      Evaluation Summary:

      This manuscript is of broad interest to readers in the field of somatosensation. The identification that a common type of skin cell responds to mechanical force using a specific molecular receptor called Piezo1 is an important contribution to our understanding of mechanotransduction. A combination of conditional gene knockout with physiological and behavioral assays provides intriguing evidence that communication between skin and nerves is important for normal touch sensation, a conclusion that if further supported by additional data could become a fundamental discovery.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    2 evaluationsAppears in 3 listsLatest version Latest activity

  13. Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

    1. Jesse R Holt
    2. Wei-Zheng Zeng
    3. Elizabeth L Evans
    4. Seung-Hyun Woo
    5. Shang Ma
    6. Hamid Abuwarda
    7. Meaghan Loud
    8. Ardem Patapoutian
    9. Medha M Pathak

    • Curated by eLife

      Evaluation Summary:

      The manuscript links a critical physiological function of the skin, wound healing to the ability of skin cells to migrate and the modification of migration by the mechanosensitive ion channel Piezo1. The topic of the manuscript is timely, relevant and would be of interest to a broad audience. The experimental design followed by the authors is straightforward and elegant, and the majority of the conclusions are well supported by the results.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 4 listsLatest version Latest activity
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