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  1. Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

    This article has 25 authors:
    1. Joanna C Porter
    2. Jamie Inshaw
    3. Vincente Joel Solis
    4. Emma Denneny
    5. Rebecca Evans
    6. Mia I Temkin
    7. Nathalia De Vasconcelos
    8. Iker Valle Aramburu
    9. Dennis Hoving
    10. Donna Basire
    11. Tracey Crissell
    12. Jesusa Guinto
    13. Alison Webb
    14. Hanif Esmail
    15. Victoria Johnston
    16. Anna Last
    17. Thomas Rampling
    18. Lena Lippert
    19. Elisa Theresa Helbig
    20. Florian Kurth
    21. Bryan Williams
    22. Aiden Flynn
    23. Pauline T Lukey
    24. Veronique Birault
    25. Venizelos Papayannopoulos
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This small-sized clinical trial comparing nebulized dornase-alfa to the best available care in patients hospitalized with COVID-19 pneumonia is valuable, but in its present form the paper is incomplete.

    Reviewed by eLife, Rapid Reviews Infectious Diseases, ScreenIT

    This article has 12 evaluationsAppears in 5 listsLatest version Latest activity
  2. Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

    This article has 29 authors:
    1. Talia Kustin
    2. Noam Harel
    3. Uriah Finkel
    4. Shay Perchik
    5. Sheri Harari
    6. Maayan Tahor
    7. Itamar Caspi
    8. Rachel Levy
    9. Michael Leshchinsky
    10. Shifra Ken Dror
    11. Galit Bergerzon
    12. Hala Gadban
    13. Faten Gadban
    14. Eti Eliassian
    15. Orit Shimron
    16. Loulou Saleh
    17. Haim Ben-Zvi
    18. Elena Keren Taraday
    19. Doron Amichay
    20. Anat Ben-Dor
    21. Dana Sagas
    22. Merav Strauss
    23. Yonat Shemer Avni
    24. Amit Huppert
    25. Eldad Kepten
    26. Ran D. Balicer
    27. Doron Netzer
    28. Shay Ben-Shachar
    29. Adi Stern

    Reviewed by NCRC, Rapid Reviews Infectious Diseases, ScreenIT

    This article has 6 evaluationsAppears in 6 listsLatest version Latest activity
  3. Malaria parasite resistance to azithromycin is not readily transmitted by mosquitoes

    This article has 7 authors:
    1. Hayley D. Buchanan
    2. Robyn McConville
    3. Lee M. Yeoh
    4. Michael F. Duffy
    5. Justin A. Boddey
    6. Geoffrey I. McFadden
    7. Christopher D. Goodman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work addressed the identifcation of antimalarial drug resistance mutations that do not readily transmit to new human hosts, focusing on azithromycin resistance. The technically challenging analyses of azithromycin-resistant parasites as they traverse the mosquito host and human liver are conducted using state-of-the-art tools, including humanized mice. While the claim regarding the lack of transmission by atovaquone-resistant P. berghei is convincing, the evidence for the lack of transmission by atovaquone-resistant P. falciparum is insufficient. This work will appeal to biologists and biomedical scientists in parasitology and drug discovery, offering insights into combating antimalarial drug resistance and understanding the fitness costs associated with drug-resistant parasites.

    Reviewed by eLife, Rapid Reviews Infectious Diseases

    This article has 9 evaluationsAppears in 3 listsLatest version Latest activity