Multiple reviews

A list by Godwyns Onwuchekwa

In this list, I am collating and highlighting preprints that has received evaluation/peer-reviews from more than one editorial group. These activities showcase the uniqueness of Sceity in aggregating feedback that would otherwise not be seen.

10 articlesLast updated

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  2. Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

    1. Joanna C Porter
    2. Jamie Inshaw
    3. Vincente Joel Solis
    4. Emma Denneny
    5. Rebecca Evans
    6. Mia I Temkin
    7. Nathalia De Vasconcelos
    8. Iker Valle Aramburu
    9. Dennis Hoving
    10. Donna Basire
    11. Tracey Crissell
    12. Jesusa Guinto
    13. Alison Webb
    14. Hanif Esmail
    15. Victoria Johnston
    16. Anna Last
    17. Thomas Rampling
    18. Lena Lippert
    19. Elisa Theresa Helbig
    20. Florian Kurth
    21. Bryan Williams
    22. Aiden Flynn
    23. Pauline T Lukey
    24. Veronique Birault
    25. Venizelos Papayannopoulos

    • Curated by eLife

      eLife assessment

      This small-sized clinical trial comparing nebulized dornase-alfa to the best available care in patients hospitalized with COVID-19 pneumonia is valuable, but in its present form the paper is incomplete.

    Reviewed by eLife, Rapid Reviews Infectious Diseases, ScreenIT

    12 evaluationsAppears in 5 listsLatest version Latest activity

  6. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

    1. Sanjay Ramakrishnan
    2. Dan V Nicolau
    3. Beverly Langford
    4. Mahdi Mahdi
    5. Helen Jeffers
    6. Christine Mwasuku
    7. Karolina Krassowska
    8. Robin Fox
    9. Ian Binnian
    10. Victoria Glover
    11. Stephen Bright
    12. Christopher Butler
    13. Jennifer L Cane
    14. Andreas Halner
    15. Philippa C Matthews
    16. Louise E Donnelly
    17. Jodie L Simpson
    18. Jonathan R Baker
    19. Nabil T Fadai
    20. Stefan Peterson
    21. Thomas Bengtsson
    22. Peter J Barnes
    23. Richard E K Russell
    24. Mona Bafadhel

    Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

    5 evaluationsAppears in 6 listsLatest version Latest activity

  7. Quantitative mapping of human hair greying and reversal in relation to life stress

    1. Ayelet M Rosenberg
    2. Shannon Rausser
    3. Junting Ren
    4. Eugene V Mosharov
    5. Gabriel Sturm
    6. R Todd Ogden
    7. Purvi Patel
    8. Rajesh Kumar Soni
    9. Clay Lacefield
    10. Desmond J Tobin
    11. Ralf Paus
    12. Martin Picard

    • Curated by eLife

      Evaluation Summary:

      This is an interesting and informative study reporting on the molecular features of reversible hair graying in humans and the connection with psychological stress. The study appears to have been very well conducted and the interpretations are generally supported by the data. While the results are primarily correlative at this stage, this work will set the stage for future more mechanistic studies and represents an important conceptual and methodological advance.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife, preLights

    5 evaluationsAppears in 3 listsLatest version Latest activity

  8. HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

    1. Thorsten G Müller
    2. Vojtech Zila
    3. Kyra Peters
    4. Sandra Schifferdecker
    5. Mia Stanic
    6. Bojana Lucic
    7. Vibor Laketa
    8. Marina Lusic
    9. Barbara Müller
    10. Hans-Georg Kräusslich

    • Curated by eLife

      Evaluation Summary:

      The authors use a variety of complementary approaches to visualize and characterize events in the first half of the HIV life cycle, with some overlap between the latter studies and the recent (and cited) Zila et al. bioRxiv paper from some of the same authors. The data are generally of high quality, and many findings are in line with recent field advances indicating that reverse transcription completes in the nucleus, that intact/nearly intact cores are imported into the nucleus, and that nuclear uncoating likely occurs immediately prior to integration. The results provide the best evidence to date that intact capsids can enter the nucleus of target cells during infection, and will generally be of interest to the field, although the impact is diminished somewhat by similar recent publications from a number of other groups (including one case that used nearly identical labeling methods to follow viral complexes during infection). Issues that should be addressed include missing controls in some cases, some examples of over-interpretation and uneven citation, and the need for additional images to help bolster some of the claims. Strengths of the study include the rigorous characterization of infection using sophisticated imaging methods and, most importantly, the use of CLEM-ET to visualize viral capsids in the nucleus.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife, PREreview

    5 evaluationsAppears in 3 listsLatest version Latest activity

  9. Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

    1. Talia Kustin
    2. Noam Harel
    3. Uriah Finkel
    4. Shay Perchik
    5. Sheri Harari
    6. Maayan Tahor
    7. Itamar Caspi
    8. Rachel Levy
    9. Michael Leshchinsky
    10. Shifra Ken Dror
    11. Galit Bergerzon
    12. Hala Gadban
    13. Faten Gadban
    14. Eti Eliassian
    15. Orit Shimron
    16. Loulou Saleh
    17. Haim Ben-Zvi
    18. Elena Keren Taraday
    19. Doron Amichay
    20. Anat Ben-Dor
    21. Dana Sagas
    22. Merav Strauss
    23. Yonat Shemer Avni
    24. Amit Huppert
    25. Eldad Kepten
    26. Ran D. Balicer
    27. Doron Netzer
    28. Shay Ben-Shachar
    29. Adi Stern

    Reviewed by NCRC, Rapid Reviews Infectious Diseases, ScreenIT

    6 evaluationsAppears in 6 listsLatest version Latest activity

  10. Malaria parasite resistance to azithromycin is not readily transmitted by mosquitoes

    1. Hayley D. Buchanan
    2. Robyn McConville
    3. Lee M. Yeoh
    4. Michael F. Duffy
    5. Justin A. Boddey
    6. Geoffrey I. McFadden
    7. Christopher D. Goodman

    • Curated by eLife

      eLife assessment

      This important work addressed the identifcation of antimalarial drug resistance mutations that do not readily transmit to new human hosts, focusing on azithromycin resistance. The technically challenging analyses of azithromycin-resistant parasites as they traverse the mosquito host and human liver are conducted using state-of-the-art tools, including humanized mice. While the claim regarding the lack of transmission by atovaquone-resistant P. berghei is convincing, the evidence for the lack of transmission by atovaquone-resistant P. falciparum is insufficient. This work will appeal to biologists and biomedical scientists in parasitology and drug discovery, offering insights into combating antimalarial drug resistance and understanding the fitness costs associated with drug-resistant parasites.

    Reviewed by eLife, Rapid Reviews Infectious Diseases

    8 evaluationsAppears in 3 listsLatest version Latest activity