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A list by Iratxe Puebla

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  2. Visualizing molecules of functional human profilin

    1. Morgan L Pimm
    2. Xinbei Liu
    3. Farzana Tuli
    4. Jennifer Heritz
    5. Ashley Lojko
    6. Jessica L Henty-Ridilla

    • Curated by eLife

      Evaluation Summary:

      This paper will be of interest to a broad audience of cell biologists and biochemists who study the cytoskeleton. It reports the development and rigorous characterization of a fully functional, fluorescently labeled version of profilin that can be used to visualize profilin's dynamic interactions in live cells. Owing to profilin's dual functions in regulating actin and microtubule assembly, this technological development will be a useful tool for a wide range of studies aimed at understanding the role of the cytoskeleton in driving fundamental cellular processes.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ASAPbio crowd review

    4 evaluationsAppears in 4 listsLatest version Latest activity

  3. Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

    1. Chelsea U Kidwell
    2. Joseph R Casalini
    3. Soorya Pradeep
    4. Sandra D Scherer
    5. Daniel Greiner
    6. Defne Bayik
    7. Dionysios C Watson
    8. Gregory S Olson
    9. Justin D Lathia
    10. Jarrod S Johnson
    11. Jared Rutter
    12. Alana L Welm
    13. Thomas A Zangle
    14. Minna Roh-Johnson

    • Curated by eLife

      eLife assessment

      This manuscript provides compelling evidence that macrophages transfer mitochondria to cancer cells and that transferred mitochondria stimulate proliferation in recipient cells. The usage an array of clever cell biology-based tools provides compelling evidence for these claims despite the difficulties associated with studying a relatively low probability event. Solid evidence supports the proposed model that transferred mitochondria induce proliferation by stimulating ERK signaling in a ROS dependent manner, although at present some aspects of the proposed model are incomplete. The work has broad significance for both mitochondrial biology and cancer biology as the authors show clear evidence of mitochondrial transfer in mouse models of human tumors.

    Reviewed by eLife, ASAPbio crowd review

    6 evaluationsAppears in 5 listsLatest version Latest activity

  4. Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B

    1. Manuel Lera-Ramirez
    2. François J Nédélec
    3. Phong T Tran

    • Curated by eLife

      Evaluation Summary:

      This study carefully quantifies microtubule dynamics during anaphase in the fission yeast S. pombe. The high quality data revealed two new observations: that microtubule rescue occurs preferentially at the edge of the midzone and that microtubule growth speed decreases when the nuclear membrane wraps around the spindle midzone in late anaphase. This sheds new light on the interplay between the nuclear membrane and the midspindle in closed mitosis, and the study will be of interest to cell biologists studying spindle dynamics and mitosis.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by ASAPbio crowd review, eLife

    6 evaluationsAppears in 3 listsLatest version Latest activity