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  1. Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism

    This article has 15 authors:
    1. See-Yeun Ting
    2. Kaitlyn D LaCourse
    3. Hannah E Ledvina
    4. Rutan Zhang
    5. Matthew C Radey
    6. Hemantha D Kulasekara
    7. Rahul Somavanshi
    8. Savannah K Bertolli
    9. Larry A Gallagher
    10. Jennifer Kim
    11. Kelsi M Penewit
    12. Stephen J Salipante
    13. Libin Xu
    14. S Brook Peterson
    15. Joseph D Mougous
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      Using a genome wide screen, the authors identify novel pathways that protect Pseudomonas aeruginosa against Type-6 secretion-mediated by other bacterial species. Importantly these pathways each protect against specific effectors. As an example, the authors further show that one factor Arc3B protects against phospholipase activity by antagonizing the production of lysophospholipids induced by phospholipase-type effectors. These findings uncover potentially conserved and unsuspected bacterial-defense pathways.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, PREreview

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  2. Human coronaviruses disassemble processing bodies

    This article has 10 authors:
    1. Mariel Kleer
    2. Rory P. Mulloy
    3. Carolyn-Ann Robinson
    4. Danyel Evseev
    5. Maxwell P. Bui-Marinos
    6. Elizabeth L. Castle
    7. Arinjay Banerjee
    8. Samira Mubareka
    9. Karen Mossman
    10. Jennifer A. Corcoran

    Reviewed by PREreview, ScreenIT

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  3. Exploring the interaction network of a synthetic gut bacterial community

    This article has 15 authors:
    1. Anna S. Weiss
    2. Anna G. Burrichter
    3. Abilash Chakravarthy Durai Raj
    4. Alexandra von Strempel
    5. Chen Meng
    6. Karin Kleigrewe
    7. Philipp C. MĂŒnch
    8. Luis Rössler
    9. Claudia Huber
    10. Wolfgang Eisenreich
    11. Lara M. Jochum
    12. Stephanie Göing
    13. Kirsten Jung
    14. Alvaro Sanchez
    15. BĂ€rbel Stecher

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

    This article has 28 authors:
    1. Shane Miersch
    2. Zhijie Li
    3. Reza Saberianfar
    4. Mart Ustav
    5. James Brett Case
    6. Levi Blazer
    7. Chao Chen
    8. Wei Ye
    9. Alevtina Pavlenco
    10. Maryna Gorelik
    11. Julia Garcia Perez
    12. Suryasree Subramania
    13. Serena Singh
    14. Lynda Ploder
    15. Safder Ganaie
    16. Rita E. Chen
    17. Daisy W. Leung
    18. Pier Paolo Pandolfi
    19. Giuseppe Novelli
    20. Giulia Matusali
    21. Francesca Colavita
    22. Maria R. Capobianchi
    23. Suresh Jain
    24. J.B. Gupta
    25. Gaya K. Amarasinghe
    26. Michael S. Diamond
    27. James Rini
    28. Sachdev S. Sidhu

    Reviewed by PREreview, ScreenIT

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  5. Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

    This article has 19 authors:
    1. Anja Dölle
    2. Bikash Adhikari
    3. Andreas KrÀmer
    4. Janik Weckesser
    5. Nicola Berner
    6. Lena-Marie Berger
    7. Mathias Diebold
    8. Magdalena M. Szewczyk
    9. Dalia Barsyte-Lovejoy
    10. Cheryl H. Arrowsmith
    11. Jakob Gebel
    12. Frank Löhr
    13. Volker Dötsch
    14. Martin Eilers
    15. Stephanie Heinzlmeir
    16. Bernhard KĂŒster
    17. Christoph Sotriffer
    18. Elmar Wolf
    19. Stefan Knapp

    Reviewed by PREreview

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  6. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

    This article has 24 authors:
    1. Sanjay Ramakrishnan
    2. Dan V Nicolau
    3. Beverly Langford
    4. Mahdi Mahdi
    5. Helen Jeffers
    6. Christine Mwasuku
    7. Karolina Krassowska
    8. Robin Fox
    9. Ian Binnian
    10. Victoria Glover
    11. Stephen Bright
    12. Christopher Butler
    13. Jennifer L Cane
    14. Andreas Halner
    15. Philippa C Matthews
    16. Louise E Donnelly
    17. Jodie L Simpson
    18. Jonathan R Baker
    19. Nabil T Fadai
    20. Stefan Peterson
    21. Thomas Bengtsson
    22. Peter J Barnes
    23. Richard E K Russell
    24. Mona Bafadhel

    Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

    This article has 5 evaluationsAppears in 6 listsLatest version Latest activity
  7. Extracellular vimentin as a target against SARS-CoV-2 host cell invasion

    This article has 16 authors:
    1. Ɓukasz Suprewicz
    2. Maxx Swoger
    3. Sarthak Gupta
    4. Ewelina Piktel
    5. Fitzroy J. Byfield
    6. Daniel V. Iwamoto
    7. Danielle Germann
    8. Joanna Reszeć
    9. Natalia MarciƄczyk
    10. Robert J. Carroll
    11. Marzena Lenart
    12. Krzysztof Pyrc
    13. Paul Janmey
    14. J.M. Schwarz
    15. Robert Bucki
    16. Alison Patteson

    Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  8. HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

    This article has 10 authors:
    1. Thorsten G. MĂŒller
    2. Vojtech Zila
    3. Kyra Peters
    4. Sandra Schifferdecker
    5. Mia Stanic
    6. Bojana Lucic
    7. Vibor Laketa
    8. Marina Lusic
    9. Barbara MĂŒller
    10. Hans-Georg KrÀusslich
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The authors use a variety of complementary approaches to visualize and characterize events in the first half of the HIV life cycle, with some overlap between the latter studies and the recent (and cited) Zila et al. bioRxiv paper from some of the same authors. The data are generally of high quality, and many findings are in line with recent field advances indicating that reverse transcription completes in the nucleus, that intact/nearly intact cores are imported into the nucleus, and that nuclear uncoating likely occurs immediately prior to integration. The results provide the best evidence to date that intact capsids can enter the nucleus of target cells during infection, and will generally be of interest to the field, although the impact is diminished somewhat by similar recent publications from a number of other groups (including one case that used nearly identical labeling methods to follow viral complexes during infection). Issues that should be addressed include missing controls in some cases, some examples of over-interpretation and uneven citation, and the need for additional images to help bolster some of the claims. Strengths of the study include the rigorous characterization of infection using sophisticated imaging methods and, most importantly, the use of CLEM-ET to visualize viral capsids in the nucleus.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife, PREreview

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity