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  1. Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimer’s Disease-linked pathologies in cultured human neurons

    This article has 14 authors:
    1. Amanda M. Snead
    2. Sruchi Patel
    3. Mia Krout
    4. Ryan S. Hippman
    5. Gabrielle Smith
    6. Diya Dileep
    7. Nitya Chagoor
    8. Rachel Shi
    9. Ricardo Linares
    10. Andrew Dobria
    11. Stephanie M. Cologna
    12. Camerron Crowder
    13. Leslie N. Aldrich
    14. Swetha Gowrishankar

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

    This article has 20 authors:
    1. Veronica H Ryan
    2. Sydney Lawton
    3. Joel F Reyes
    4. James Hawrot
    5. Ashley M Frankenfield
    6. Sahba Seddighi
    7. Daniel M Ramos
    8. Jacob Epstein
    9. Faraz Faghri
    10. Nicholas L Johnson
    11. Jizhong Zou
    12. Martin Kampmann
    13. John Replogle
    14. Yue Andy Qi
    15. Hebao Yuan
    16. Kory Johnson
    17. Dragan Maric
    18. Ling Hao
    19. Mike A Nalls
    20. Michael Emmerson Ward
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this important manuscript, Ryan et al perform a genome-wide CRISPR based screen to identify genes that modulate TDP-43 levels in neurons. They identify a number of genes and pathways and highlight the BORC complex, which is required for anterograde lysosome transport as one such regulator of TDP-43 protein levels. Overall, this is a convincing study, which opens the door for additional future investigations on the regulation of TDP-43.

    Reviewed by eLife, PREreview

    This article has 10 evaluationsAppears in 2 listsLatest version Latest activity
  3. Safety and Efficacy of Chimeric Antigen Receptor T-cell Therapy for Recurrent Glioblastoma: An Augmented Meta-analysis of Phase 1 Clinical Trials

    This article has 14 authors:
    1. Ahmed Y. Azzam
    2. Mahmoud M. Morsy
    3. Mohammed A. Azab
    4. Osman Elamin
    5. Adam Elswedy
    6. Omar S. Ahmed
    7. Mahmoud Nassar
    8. Ahmed Saad Al Zomia
    9. Adham A. Mohamed
    10. Oday Atallah
    11. Ahmed Alamoud
    12. Hammam A. Alotaibi
    13. Hana J. Abukhadijah
    14. Abdulqadir J Nashwan

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity