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  1. Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain

    This article has 12 authors:
    1. Aleksandra Białas
    2. Thorsten Langner
    3. Adeline Harant
    4. Mauricio P Contreras
    5. Clare EM Stevenson
    6. David M Lawson
    7. Jan Sklenar
    8. Ronny Kellner
    9. Matthew J Moscou
    10. Ryohei Terauchi
    11. Mark J Banfield
    12. Sophien Kamoun
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      Convergent evolution is often observed in nature, but the molecular mechanisms allowing similar functions to independently emerge are rarely understood. This work determines how the high-affinity recognition of a pathogenic effector produced by the rice blast fungus, Avr-PikD, evolved in the immune receptor Pik-1. The integration of molecular evolution analyses with structure-function biochemical testing is novel to the field and the data quality is exceptional. In addition to advancing knowledge of host-microbe co-evolution, this work is exemplary in its transparency and the breadth of approaches utilized to understand protein evolution, and we expect that this study will provide a conceptual framework for similar studies in the future.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife, PREreview

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity