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  1. iGABASnFR2: Improved genetically encoded protein sensors of GABA

    This article has 19 authors:
    1. Ilya Kolb
    2. Jeremy P Hasseman
    3. Akihiro Matsumoto
    4. Thomas P Jensen
    5. Olga Kopach
    6. Benjamin J Arthur
    7. Yan Zhang
    8. Arthur Tsang
    9. Daniel Reep
    10. Getahun Tsegaye
    11. Jihong Zheng
    12. Ronak H Patel
    13. Loren L Looger
    14. Jonathan S Marvin
    15. Wyatt L Korff
    16. Dmitri A Rusakov
    17. Keisuke Yonehara
    18. GENIE Project Team
    19. Glenn C Turner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript reports the development and characterization of iGABASnFR2, a genetically encoded GABA sensor that demonstrates substantially improved performance compared to its predecessor, iGABASnFR1. The work is comprehensive and methodologically rigorous, combining high-throughput mutagenesis, functional screening, structural analysis, biophysical characterization, and in vivo validation. The significance of the findings is fundamental, and the supporting evidence is compelling. iGABASnFR2 represents a notable advance in GABA sensor engineering, enabling enhanced imaging of GABA transmission both in brain slices and in vivo, and constitutes a timely, technically robust addition to the molecular toolkit for neuroscience research.

    Reviewed by eLife, PREreview

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. RNA triggers chronic stress during neuronal aging

    This article has 12 authors:
    1. Kevin Rhine
    2. Elle Epstein
    3. Natasha M. Carlson
    4. Xuezhen Ge
    5. Orel Mizrahi
    6. Anika Kamat
    7. Anita Hermann
    8. William R. Brothers
    9. John Ravits
    10. Eric J. Bennett
    11. Gülçin Pekkurnaz
    12. Gene W. Yeo

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Coxsackievirus A24: A Causative Agent of Acute Haemorrhagic Conjunctivitis Outbreak in Dar es Salaam, Tanzania, between January and February 2024

    This article has 21 authors:
    1. Lawrence A. Mapunda
    2. Peter van Heusden
    3. Robert Baluhya
    4. Olympia G. Machange
    5. Ambele Mwafulango
    6. Monica Fredrick Francis
    7. Aziz Ituka
    8. Omega Machange
    9. Adela Kisanga
    10. Edna E. Mgimba
    11. Hamza H. Matimba
    12. Dennis M. Kado
    13. Elson E. Kimaro
    14. Ramadhani A. Libenanga
    15. Jackson Peter Mushumbusi
    16. Hamisi M. Swalehe
    17. Ibrahim Mauki
    18. James Hellar
    19. Shimba Henerico
    20. Maria E. Kelly
    21. Nyambura Moremi

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity