Reading List

TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience

1. Yiechang Lin
2. Zijing Zhou
3. Yaoyao Han
4. Delfine Cheng
5. Haoqing Wang
6. Arnold Lining Ju
7. Yixiao Zhang
8. Charles D Cox
9. Ben Corry

A LARGE-SCALE EVOLUTIONARY AND STRUCTURAL ANALYSIS OF CLC CHANNELS AND TRANSPORTERS

1. Ayush Mishra
2. Gladys Díaz Vázquez
3. Janice L. Robertson

Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer

1. Pooneh Koochaki
2. Biao Qiu
3. Jesse A. Coker
4. Alexander Earsley
5. Nancy S. Wang
6. Todd Romigh
7. Christopher M. Goins
8. Shaun R. Stauffer
9. Olga Boudker
10. Abhishek A. Chakraborty

UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation

1. Aikaterini Vrentzou
2. Florian Leidner
3. Claudia C. Schmidt
4. Helmut Grubmüller
5. Alexander Stein

Integrative structural analysis of the human endosomal Na⁺/H⁺ exchanger NHE6 reveals a lipid-stabilized intracellular gate and a disordered C-terminus

1. Lukas Peter Feilen
2. Emil Enshelm Tranchant
3. Milena Rankilde Lilac
4. Lara Kristin Sach
5. Jesper Havelund
6. Jan Ostendorf
7. Nils J Faergeman
8. Stine Falsig Pedersen
9. Birthe B. Kragelund
10. Henriette Autzen

ABEL-FRET bridges the timescale gap in single-molecule measurements of the structural dynamics in the A2A adenosine receptor

1. Ivan Maslov
2. Valentin I. Borshchevskiy
3. Vadim Cherezov
4. Johan Hofkens
5. Jelle Hendrix
6. Michael Börsch
7. Thomas Gensch

A planar dimer of bovine ATP synthase

1. Chimari Jiko
2. Atsuki Nakano
3. Yosuke Teshirogi
4. Eiki Yamashita
5. Genji Kurisu
6. Daron M Standley
7. Tohru Terada
8. Kaoru Mitsuoka
9. Ken Yokoyama
10. Christoph Gerle

Evaluating the ligands’ potency to modulate the fast inactivation of voltage-gated sodium channel

1. Beata Niklas
2. Milena Jankowska
3. Katarzyna Walczewska-Szewc
4. Bruno Lapied
5. Wiesław Nowak

Real-time visualization of ligand-specific conformational dynamics of GPCR C-terminal domain in living cells

1. Zhao Lin
2. Xinyao Chen
3. Lijuan Ma
4. Hang Fu
5. Hao Wang
6. Kai Yang
7. Zijian Li
8. Fangfu Ye
9. Ying Lu
10. Shuxin Hu
11. Ming Li

CaMKII monomers are sufficient for GluN2B binding, co-condensation, and synaptic potentiation

1. Carolyn Nicole Brown
2. C. Madison Barker
3. Carley N. Miller
4. Jason Aoto
5. Steven J. Coultrap
6. K. Ulrich Bayer

Cryo-EM structures of naturally occurring dimeric photosystem II complexes lacking the Mn ₄ CaO ₅ cluster

1. Ziyu Zhao
2. Irene Vercellino
3. Julian P. Whitelegge
4. Karim Maghlaoui
5. Peter J. Nixon
6. Leonid A. Sazanov

Principles of ribosome-associated protein quality control during the synthesis of CFTR

1. Tom Joshua Oldfield
2. Robin Renn
3. Débora Broch Trentini

Allosteric effects of the coupling cation in melibiose transporter MelB

1. Parameswaran Hariharan
2. Yuqi Shi
3. Rosa Viner
4. Lan Guan

• Curated by eLife

  eLife Assessment

  This manuscript presents useful insights into the molecular basis underlying the positive cooperativity between the co-transported substrates (galactoside sugar and sodium ion) in the melibiose transporter MelB. Building on years of previous studies, this work improves on the resolution of previously published structures and reports the presence of a water molecule in the sugar binding site that would appear to be key for its recognition, introduces further structures bound to different substrates, and utilizes HDX-MS to further understand the positive cooperativity between sugar and the co-transported sodium cation. Although the experimental work is solid, the presentation of the data lacks clarity, and in particular, the HDX-MS data interpretation requires further explanation in both methodology and discussion, as well as a clearer description of the new insight that is obtained in relation to previous studies. The work will be of interest to biologists and biochemists working on cation-coupled symporters, which mediate the transport of a wide range of solutes across cell membranes.

Reviewed by eLife

Cytoplasmic tail composition modulates the G protein and arrestin-3 signaling bias of the adhesion GPCR LPHN2

1. Krassimira Garbett
2. Chen Zheng
3. Julia Drube
4. Carsten Hoffmann
5. Vsevolod Gurevich
6. Richard Sando

Non-equilibrium Thermodynamics Modulate TRPV1 Channel Activation via Tissue Entropy Production

1. Abderrahim Lyoubi-Idrissi

Membrane potential bistability in human breast cancer MDA-MB-231 cells: A ‘Hodgkin-Huxley type’ model

1. Suvabrata De
2. Mustafa B. A. Djamgoz

In situ Structure of the Human Gap Junction

1. Evans Eshriew
2. Esa-Pekka Kumpula
3. Shiv K. Sah-Teli
4. Amiel Abettan
5. Amina Djurabekova
6. Vivek Sharma
7. Juha T. Huiskonen

Lipid composition effects on the number and size of liposomes formed by the inverted emulsion method

1. Hibiki Sakata
2. Hitomi Matubara
3. Kanako Gomi
4. Makito Miyazaki

Influence of Disease-Causing Mutations and Ivacaftor on the Dynamics of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein

1. Diana-F. Veselu
2. Deborah K. Shoemark
3. Marc W. van der Kamp

Sometimes extracellular recordings fail for good reasons

1. Karoline Horgmo Jaeger
2. Aslak Tveito