Reading List

Molecular mechanism of substrate transport by human peroxisomal ABCD3

1. Meghna Gupta
2. Nitesh Kumar Khandelwal
3. Devin J. Seka
4. Sree Ganesh Balasubramani
5. Miles Sasha Dickinson
6. Alexander Myasnikov
7. Ignacia Echeverria
8. Robert M. Stroud

Allosteric Control of Super-Agonism in a Ligand-Gated Ion Channel

1. Franco Viscarra
2. Teresa Minguez
3. Isabel Bermudez-Diaz
4. Philip C Biggin

Multiple weak brakes act in concert to regulate STIM1 and control store-operated calcium entry

1. Ruoyi Qiu
2. Richard S. Lewis

TRPM8 Protein Dynamics Correlates with Ligand Structure and Cellular Function

1. Mubark D. Mebrat
2. Dustin D. Luu
3. Jacob K. Hilton
4. Minjoo Kim
5. Kaitlyn Parrott
6. Brian R. Cherry
7. Marcia Levitus
8. V. Blair Journigan
9. Wade D. Van Horn

Development of visible light-sensitive human OPN5 via single amino acid substitution

1. Yusuke Sakai
2. Richard J. McDowell
3. Robert J. Lucas

Structure-based identification of GIRK2-PIP2 modulators among known drugs and metabolites using docking, MM-GBSA, ADMET, and molecular dynamics

1. Danko Jeremic
2. Lydia Jiménez-Díaz
3. Juan D. Navarro-López

The Role of Chloride Ions in Serotonin Transport

1. Jiahui Huang
2. Annika Backer
3. Stacy Uchendu
4. Bethlehem Bekele
5. Qingyang Chen
6. Esam Orabi
7. Robyn Stix
8. Yuan-Wei Zhang
9. Gary Rudnick
10. Eva Hellsberg
11. Lucy R. Forrest

Carboxyl Terminal Domain Missense Mutations Alter Distinct Gating Properties of the Cardiac Sodium Channel

1. Akshay Sharma
2. Christopher Marra
3. Nomon Mohammad
4. Vasilisa Iatckova
5. Lillian Lawrence
6. Mitchell Goldfarb

Identification and Rescue of Congenital Hyperinsulinism-Associated ABCC8 Mutations that Impair K _ATP Channel Trafficking

1. Assmaa ElSheikh
2. Yi-Ying Kuo
3. Kara E. Boodhansingh
4. Zhongying Yang
5. Charles A. Stanley
6. Diva D. De Leon
7. Show-Ling Shyng

Closed State Structure of the Pore Revealed by Uncoupled Shaker K+ Channel

1. Francisco Bezanilla
2. Yichen Liu
3. Carlos Bassetto
4. Gustavo Contreras
5. Eduardo Perozo

Conformational biosensors delineate endosomal G protein regulation by GPCRs

1. Brian Wysolmerski
2. Emily E. Blythe
3. Mark von Zastrow

Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter

1. Yuhan Jiang
2. Michael Nikolovski
3. Tianqi Wang
4. Keith MacRenaris
5. Thomas V. O’Halloran
6. Jian Hu

Structural insights into allosteric mechanism of glycine transporter-mediated analgesia

1. Ryan P. Cantwell Chater
2. Julian Peiser-Oliver
3. Tanmay K. Pati
4. Ada S. Quinn
5. Irina Lotsaris
6. Zachary J. Frangos
7. Anna E. Tischer
8. Billy J Williams-Noonan
9. Megan L. O’Mara
10. Michael Michaelides
11. Sarasa A. Mohammadi
12. Christopher L. Cioffi
13. Robert J. Vandenberg
14. Azadeh Shahsavar

Conduction pathway for potassium through the E. coli pump KdpFABC

1. Adel Hussein
2. Xihui Zhang
3. Bjørn Panyella Pedersen
4. David L Stokes

• Curated by eLife

  eLife Assessment

  This valuable study provides new insights into the movement of ions through the bacterial pump KdpFABC, which regulates intracellular potassium concentration, by solving a 2.1 Å cryo-EM structure of the nanodisc-embedded active wild-type protein, and carrying out mutagenesis and activity assays. Although the structural data and analysis are solid, additional information about other structural classes identified in the EM data, as well as a discussion of relevant work done by others, would further strengthen these findings. The description of the activity assays is currently incomplete because more information is required to rigorously assess these experiments. This work will be of interest to the membrane transporter and channel communities and to microbiologists interested in osmoregulation and potassium homeostasis.

Reviewed by eLife

Molecular mechanism of exchange coupling in CLC chloride/proton antiporters

1. Deniz Aydin
2. Chih-Ta Chien
3. Jürgen Kreiter
4. Amy Nava
5. Jasmina M. Portasikova
6. Lukas Fojtik
7. Catalina Mosquera Salcedo
8. Petr Man
9. Ron O. Dror
10. Wah Chiu
11. Merritt Maduke

Optical single-channel recording via diffusional confinement in membrane tethers

1. Madeleine R. Howell
2. Adam E. Cohen

GRKs phosphorylate GPCR C-terminal peptides in a hierarchical manner

1. Arnelle Löbbert
2. Nils Lorz
3. Edda S. F. Matthees
4. Philip Rößler
5. Carsten Hoffmann
6. Alvar D. Gossert

Profiling of HCAR1 signaling reveals Gα _i/o and Gα _s activation without β-arrestin recruitment and the discovery of an allosteric agonist

1. Simon Lind
2. Shane C. Wright
3. Emilia Gvozdenovic
4. Kristina Nilsson
5. Kenneth L. Granberg
6. Michel Bouvier
7. Linda C. Johansson

A Novel Model for Proton Transport Mediated by Uncoupling Protein 1

1. Luise Jacobsen
2. Sneha Menon
3. Michael J Gaudry
4. Ali Asghar Hakami Zanjani
5. Peter Reinholdt
6. Martin Jastroch
7. Himanshu Khandelia

Deep Learning-Based Classification of Peptide Analytes from Single-Channel Nanopore Translocation Events

1. Bryan A. Krantz