Reading List

A list by Biophysics Colab

Articles that are being read by Biophysics Colab.

1044 articlesLast updated

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  5. Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter

    1. Steven J Middleton
    2. Sigurbjörn Markússon
    3. Mikael Åkerlund
    4. Justin C. Deme
    5. Mandy Tseng
    6. Wenqianglong Li
    7. Sana R Zuberi
    8. Gabriel Kuteyi
    9. Peter Sarkies
    10. Georgios Baskozos
    11. Jimena Perez-Sanchez
    12. Harry L Hébert
    13. Sylvanus Toikumo
    14. Adham Farah
    15. Susan Maxwell
    16. Yin Y Dong
    17. Henry R Kranzler
    18. John E Linley
    19. Blair H Smith
    20. Susan M. Lea
    21. Joanne L Parker
    22. Valeriya Lyssenko
    23. Simon Newstead
    24. David L Bennett
    Appears in 1 listLatest version

  6. Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove

    1. Christina Alexandra Stephens
    2. Niek van Hilten
    3. Lisa Zheng
    4. Michael Grabe

    • Curated by eLife

      eLife Assessment

      This important study provides information on the TMEM16 family of membrane proteins, which play roles in lipid scrambling and ion transport. By simulating 27 structures representing five distinct family members, the authors captured hundreds of lipid scrambling events, offering insights into the mechanisms of lipid translocation and the specific protein regions involved in these processes. However, while the data on groove dilation is compelling, the evidence for outside-the-groove scramblase activity without experimental validation is inadequate and is based on a limited set of observed events.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  8. Twist is the key to the gating of mechanosensitive ion channel NOMPC

    1. Jingze Duan
    2. Chen Song

    • Curated by eLife

      eLife Assessment

      This valuable study uses steered molecular dynamics simulations to interrogate force transmission in the mechanosensitive NOMPC channel, which plays roles including soft-touch perception, auditory function, and locomotion. The finding that the ankyrin spring transmits force through torsional rather than compression forces may help understand the entire TRP channel family. The evidence is, however, considered to be still incomplete. It could be strengthened by testing how the channel responds to different twisting and compressional force magnitudes over longer simulation times to see a full gating motion, or to prove that the partial or initial motion observed relates to physiological gating. Experimental validation of reduced mechano-sensitivity through mutagenesis of proposed ankyrin/TRP domain coupling interactions would be best to enhance the manuscript.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity
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