Reading List

Conduction pathway for potassium through the E. coli pump KdpFABC

1. Adel Hussein
2. Xihui Zhang
3. Bjørn Panyella Pedersen
4. David L Stokes

• Curated by eLife

  eLife Assessment

  This valuable study provides new insights into the movement of ions through the bacterial pump KdpFABC, which regulates intracellular potassium concentration, by solving a 2.1 Å cryo-EM structure of the nanodisc-embedded active wild-type protein, and carrying out mutagenesis and activity assays. Although the structural data and analysis are solid, additional information about other structural classes identified in the EM data, as well as a discussion of relevant work done by others, would further strengthen these findings. The description of the activity assays is currently incomplete because more information is required to rigorously assess these experiments. This work will be of interest to the membrane transporter and channel communities and to microbiologists interested in osmoregulation and potassium homeostasis.

Reviewed by eLife

Molecular mechanism of exchange coupling in CLC chloride/proton antiporters

1. Deniz Aydin
2. Chih-Ta Chien
3. Jürgen Kreiter
4. Amy Nava
5. Jasmina M. Portasikova
6. Lukas Fojtik
7. Catalina Mosquera Salcedo
8. Petr Man
9. Ron O. Dror
10. Wah Chiu
11. Merritt Maduke

Optical single-channel recording via diffusional confinement in membrane tethers

1. Madeleine R. Howell
2. Adam E. Cohen

GRKs phosphorylate GPCR C-terminal peptides in a hierarchical manner

1. Arnelle Löbbert
2. Nils Lorz
3. Edda S. F. Matthees
4. Philip Rößler
5. Carsten Hoffmann
6. Alvar D. Gossert

Profiling of HCAR1 signaling reveals Gα _i/o and Gα _s activation without β-arrestin recruitment and the discovery of an allosteric agonist

1. Simon Lind
2. Shane C. Wright
3. Emilia Gvozdenovic
4. Kristina Nilsson
5. Kenneth L. Granberg
6. Michel Bouvier
7. Linda C. Johansson

A Novel Model for Proton Transport Mediated by Uncoupling Protein 1

1. Luise Jacobsen
2. Sneha Menon
3. Michael J Gaudry
4. Ali Asghar Hakami Zanjani
5. Peter Reinholdt
6. Martin Jastroch
7. Himanshu Khandelia

Deep Learning-Based Classification of Peptide Analytes from Single-Channel Nanopore Translocation Events

1. Bryan A. Krantz

Activity deprivation modulates the Shank3/Homer1/mGluR5 signaling pathway to enable synaptic upscaling

1. Andrea A. Guerrero
2. Gina G. Turrigiano

The non-thermogenic function of opossum UCP1 is independent of its cytoplasmic binding network

1. Giorgia Roticiani
2. Jürgen Kreiter
3. Elena E. Pohl

De novo Design of a Peptide Modulator to Reverse Sodium Channel Dysfunction Linked to Cardiac Arrhythmias and Epilepsy

1. Ryan Mahling
2. Bence Hegyi
3. Erin Cullen
4. Timothy M. Cho
5. Aaron Rodriques
6. Lucile Fossier
7. Marc Yehya
8. Lin Yang
9. Bi-Xing Chen
10. Alexander N. Katchman
11. Nourdine Chakouri
12. Ruiping Ji
13. Elaine Wan
14. Jared Kushner
15. Steven O. Marx
16. Sergey Ovchinnikov
17. Christopher Makinson
18. Donald M. Bers
19. Manu Ben-Johny

Synergistic roles of Aquaporin 5 and Intra- and Extracellular Carbonic Anhydrases in promoting CO ₂ Diffusion across the Xenopus Oocyte Plasma Membrane

1. Deng-Ke Wang
2. Fraser J. Moss
3. Walter F. Boron

Functional and Structural Characterization of F ₁ -ATPase with common ancestral core domains in stator ring

1. Aya K. Suzuki
2. Ryutaro Furukawa
3. Meghna Sobti
4. Simon H. J. Brown
5. Alastair G. Stewart
6. Satoshi Akanuma
7. Hiroshi Ueno
8. Hiroyuki Noji

Mechanistic basis for GPCR phosphorylation-dependent allosteric signaling specificity of β -arrestin 1 and 2

1. Midhun K Madhu
2. Rajesh K Murarka

Structural basis for no retinal binding in flotillin-associated rhodopsins

1. Kirill Kovalev
2. Artem Stetsenko
3. Florian Trunk
4. Egor Marin
5. Jose M Haro-Moreno
6. Gerrit H.U. Lamm
7. Alexey Alekseev
8. Francisco Rodriguez-Valera
9. Thomas R. Schneider
10. Josef Wachtveitl
11. Albert Guskov

Surface morphometrics reveals local membrane thickness variation in organellar subcompartments

1. Michaela Medina
2. Ya-Ting Chang
3. Hamidreza Rahmani
4. Daniel Fuentes
5. Benjamin A. Barad
6. Danielle A. Grotjahn

Shape-Shifting Conotoxins Reveal Divergent Pore-Targeting Mechanisms in Nicotinic Receptors

1. Biddut Bhattacharjee
2. Colleen M. Noviello
3. Md Mahfuz Rahman
4. John P. Mayer
5. Joanna Gajewiak
6. J. Michael McIntosh
7. Ryan E. Hibbs
8. Michael H. B. Stowell

Structural basis for proton inhibition of the two-pore domain K ⁺ channel TASK-1

1. Trevor Docter
2. Michelle S. Reid
3. Nicolas S. Lee
4. Stephen G. Brohawn

Cation-controlled assembly, activity, and organisation of biomimetic DNA receptors in synthetic cell membranes

1. Elita Peters
2. Diana A. Tanase
3. Lorenzo Di Michele
4. Roger Rubio-Sánchez

Packing of apolar amino acids is not a strong stabilizing force in transmembrane helix dimerization

1. Gilbert J. Loiseau
2. Alessandro Senes

DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings

1. Larissa Ferguson
2. Sébastien Ouellet
3. Elke Vandewyer
4. Christopher Wang
5. Zaw Wunna
6. Tony K.Y. Lim
7. William R. Schafer
8. Isabel Beets