Reading list

Structural determinants of protein kinase A essential for CFTR channel activation

1. Csaba Mihályi
2. Iordan Iordanov
3. András Szöllősi
4. László Csanády

The structures of protein kinase A in complex with CFTR: mechanisms of phosphorylation and reversible activation

1. Karol Fiedorczuk
2. Iordan Iordanov
3. Csaba Mihályi
4. András Szöllősi
5. László Csanády
6. Jue Chen

Endocannabinoid regulation of inward rectifier potassium (Kir) channels

1. Sultan Mayar
2. Mariia Borbuliak
3. Andreas Zoumpoulakis
4. Tahar Bouceba
5. Madeleine M. Labonté
6. Ameneh Ahrari
7. Niveny Sinniah
8. Mina Memarpoor-Yazdi
9. Catherine Vénien-Bryan
10. D. Peter Tieleman
11. Nazzareno D’Avanzo

Structural Insights into Subunit-Dependent Functional Regulation in Epithelial Sodium Channels

1. Alexandra Houser
2. Isabelle Baconguis

Piezo1 ion channels are capable of conformational signaling

1. Amanda H. Lewis
2. Marie E. Cronin
3. Jörg Grandl

Structure of the II2-III2-IV2 mitochondrial supercomplex from the parasite Perkinsus marinus

1. Fēi Wú
2. Alexander Mühleip
3. Thomas Gruhl
4. Lilach Sheiner
5. Amandine Maréchal
6. Alexey Amunts

Dynamic basis of lipopolysaccharide export by LptB2FGC

1. Marina Dajka
2. Tobias Rath
3. Nina Morgner
4. Benesh Joseph

• Curated by eLife

  eLife assessment

  This study provides an important advance in the molecular understanding of the lipopolysaccharide export mechanism and machinery in bacteria. By using advanced spectroscopy approaches, the experiments provide convincing biophysical support for the dynamic behavior of the multisubunit Lpt transport system. This work has implications for understanding bacterial cell envelope biogenesis and developing drugs that target Gram negative pathogens.

Reviewed by eLife

Molecular phenotypes segregate missense mutations in SLC13A5 Epilepsy

1. Valeria Jaramillo-Martinez
2. Souad R. Sennoune
3. Elena B. Tikhonova
4. Andrey L. Karamyshev
5. Vadivel Ganapathy
6. Ina L. Urbatsch

Opto-chemogenetic inhibition of L-type Ca _V 1 channels in neurons through a membrane-assisted molecular linkage

1. Jinli Geng
2. Yaxiong Yang
3. Boying Li
4. Zhen Yu
5. Shuang Qiu
6. Wen Zhang
7. Shixin Gao
8. Nan Liu
9. Yi Liu
10. Bo Wang
11. Yubo Fan
12. Chengfen Xing
13. Xiaodong Liu

CONSTITUTIVE OPENING OF THE Kv7.2 PORE ACTIVATION GATE CAUSES KCNQ2 -DEVELOPMENTAL ENCEPHALOPATHY

1. Mario Nappi
2. Giulio Alberini
3. Alessandro Berselli
4. Agnese Roscioni
5. Maria Virginia Soldovieri
6. Vincenzo Barrese
7. Sarah Weckhuysen
8. Ting-Gee Annie Chiu
9. Ingrid E. Scheffer
10. Fabio Benfenati
11. Luca Maragliano
12. Francesco Miceli
13. Maurizio Taglialatela

Conservation of the cooling agent binding pocket within the TRPM subfamily

1. Kate Huffer
2. Matthew CS Denley
3. Elisabeth V Oskoui
4. Kenton J Swartz

• Curated by eLife

  eLife Assessment

  In this valuable study, Huffer et al posit that non-cold sensing members of the TRPM subfamily of ion channels (e.g., TRPM2, TRPM4, TRPM5) contain a binding pocket for icilin that overlaps with the one found in the cold-activated TRPM8 channel. After examining a body of TRP channel cryo-EM structures to identify the conserved site, this study presents convincing electrophysiological evidence supporting the presence of an icilin binding pocket within TRPM4. This study shows that icilin has modulatory effects on the TRPM4 channel and will be of direct interest to those working in the TRP-channel field, but it also has implications for studies of somatosensation, taste, as well as pharmacological targeting of the TRPM subfamily.

Reviewed by eLife

The roles of an extended N-terminal region and ETD motif in a pump-like cation channelrhodopsin discovered in a lake microbiome

1. Shunki Takaramoto
2. Shai Fainsod
3. Takashi Nagata
4. Andrey Rozenberg
5. Oded Béjà
6. Keiichi Inoue

Cryo-EM structure of the bicarbonate receptor GPR30

1. Shota Kaneda
2. Airi Jo-Watanabe
3. Hiroaki Akasaka
4. Hidetaka S Oshima
5. Takehiko Yokomizo
6. Wataru Shihoya
7. Osamu Nureki

• Curated by eLife

  eLife assessment

  This study resolves a cryo-EM structure of the GPCR, human GPR30, which responds to bicarbonate and regulates cellular responses to pH and ion homeostasis. Understanding the ligand and the mechanism of activation is important to the field of receptor signaling and potentially facilitates drug development targeting this receptor. While the overall structures are solid, the identification of the bicarbonate binding site is only partly supported by the structural data and cell-based functional assays, leaving a major aim of the study incomplete.

Reviewed by eLife

Proline substitutions in the ASIC1 β11-12 linker slow desensitization

1. Rutambhara Purohit
2. Tyler Couch
3. David M. MacLean

Protein modelling and thermodynamics reveal that plant cation-chloride cotransporters mediate potassium-chloride symport

1. Sam W Henderson
2. Saeed Nourmohammadi
3. Maria Hrmova

Structural insights into Pseudomonas aeruginosa lysine-specific uptake mechanism for extremely low pH regulation

1. Deniz Bicer
2. Rei Matsuoka
3. Aurélien F. A. Moumbock
4. Preethi Sukumar
5. Harish Cheruvara
6. Andrew Quigley
7. Els Pardon
8. Jan Steyaert
9. Peter J.F. Henderson
10. Martin Caffrey
11. Julia J. Griese
12. Emmanuel Nji

Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex

1. Christy M. Hadfield
2. John K. Walker
3. Chris Arnatt
4. Kyle S. McCommis

Homodimerization of CB ₂ cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

1. Gemma Navarro
2. Marc Gómez-Autet
3. Paula Morales
4. Joan Biel Rebassa
5. Claudia Llinas del Torrent
6. Nadine Jagerovic
7. Leonardo Pardo
8. Rafael Franco

Optimizing Coarse-Grained Models for Large-Scale Membrane Protein Simulation

1. Chen Yun Wen
2. Yun Lyna Luo
3. Jesper J. Madsen

Structure of the turnover-ready state of an ancestral respiratory complex I

1. Bozhidar S. Ivanov
2. Hannah R. Bridges
3. Owen D. Jarman
4. Judy Hirst