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A list by Biophysics Colab

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  13. Redox regulation of KV7 channels through EF3 hand of calmodulin

    1. Eider Nuñez
    2. Frederick Jones
    3. Arantza Muguruza-Montero
    4. Janire Urrutia
    5. Alejandra Aguado
    6. Covadonga Malo
    7. Ganeko Bernardo-Seisdedos
    8. Carmen Domene
    9. Oscar Millet
    10. Nikita Gamper
    11. Alvaro Villarroel

    • Curated by eLife

      eLife assessment

      Oxidation regulation of neuronal Kv7 channels contributes to the regulation of brain excitability. The manuscript concludes that this regulation is due to a disruption of the interaction between the S2S3 linker of Kv7 with the CaM EF3 site. The proposed mechanism is potentially important, but there are several weaknesses with the presentation and interpretation of the data that need to be addressed.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  15. The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

    1. Alexandria N Miller
    2. Patrick R Houlihan
    3. Ella Matamala
    4. Deny Cabezas-Bratesco
    5. Gi Young Lee
    6. Ben Cristofori-Armstrong
    7. Tanya L Dilan
    8. Silvia Sanchez-Martinez
    9. Doreen Matthies
    10. Rui Yan
    11. Zhiheng Yu
    12. Dejian Ren
    13. Sebastian E Brauchi
    14. David E Clapham

    • Curated by eLife

      eLife assessment

      The function of specific proteins made by SARS-CoV-1 and SARS-CoV-2 is under debate, with diverging claims previously published regarding the ability of Orf3a proteins from either virus to form ion channels. The authors undertook a thorough characterization of Orf3a from CoV-1 and CoV-2 by combining data from a range of different structural and functional experiments, arguably providing the most compelling evidence to date that Orf3a from viruses is not an ion channel. Instead, the orthologue-specific interaction with a component of a larger protein complex suggests a role of one of the two membrane proteins in the endo-lysosomal pathway. The work is significant from a fundamental science perspective, for its implications for COVID antiviral development strategies, and also for establishing guidelines for future identification of true viral ion channels.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  16. Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC

    1. James Osei-Owusu
    2. Zheng Ruan
    3. Ljubica Mihaljević
    4. Daniel S Matasic
    5. Kevin Hong Chen
    6. Wei Lü
    7. Zhaozhu Qiu

    • Curated by eLife

      eLife assessment

      This valuable work, of interest to ion channel physiologists, identifies regions involved in the desensitization of the proton-activated chloride channel (PAC), a widely expressed ion channel involved in organelle pH homeostasis and acid-induced cell death. At the present stage the data only incompletely support the interpretations, and further experiments will be required to consolidate some of the authors' claims.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity
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