Reading List

Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport causing congenital hypophosphatemia

1. W Bruce Sneddon
2. Peter A Friedman
3. Tatyana Mamonova

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk

1. Chon Lok Lei
2. Dominic G. Whittaker
3. Gary R. Mirams

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

1. Dylan S. Eiger
2. Jeffrey S. Smith
3. Tujin Shi
4. Tomasz Maciej Stepniewski
5. Chia-Feng Tsai
6. Christopher Honeycutt
7. Noelia Boldizsar
8. Julia Gardner
9. Carrie D. Nicora
10. Ahmed M. Moghieb
11. Kouki Kawakami
12. Issac Choi
13. Chloe Hicks
14. Kevin Zheng
15. Anmol Warman
16. Priya Alagesan
17. Nicole M. Knape
18. Ouwen Huang
19. Justin D. Silverman
20. Richard D. Smith
21. Asuka Inoue
22. Jana Selent
23. Jon M. Jacobs
24. Sudarshan Rajagopal

Hem25p is a mitochondrial IPP transporter

1. Jonathan Tai
2. Rachel M. Guerra
3. Sean W. Rogers
4. Zixiang Fang
5. Laura K. Muehlbauer
6. Evgenia Shishkova
7. Katherine A. Overmyer
8. Joshua J. Coon
9. David J. Pagliarini

Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer

1. Aniruddha Panda
2. Fabian Giska
3. Anna L. Duncan
4. Alexander J. Welch
5. Caroline Brown
6. Rachel McAllister
7. Parameswaran Hariharan
8. Jean N. D. Goder
9. Jeff Coleman
10. Sathish Ramakrishnan
11. Frédéric Pincet
12. Lan Guan
13. Shyam Krishnakumar
14. James E. Rothman
15. Kallol Gupta

Anesthetic-Binding Induced Motion of GABA _A Receptors Revealed by Coarse-Grained Molecular Dynamics Simulations

1. Shuya Nakata
2. Yoshiharu Mori
3. Shigenori Tanaka

Transcending Markov: non-Markovian rate processes of thermosensitive TRP ion channels

1. Yuval Ben-Abu
2. Stephen J Tucker
3. Sonia Contera

Structural insights into the allosteric inhibition of P2X4 receptors

1. Cheng Shen
2. Yuqing Zhang
3. Wenwen Cui
4. Yimeng Zhao
5. Danqi Sheng
6. Xinyu Teng
7. Miaoqing Shao
8. Muneyoshi Ichikawa
9. Jin Wang
10. Motoyuki Hattori

Distinct activation mechanisms of β-arrestin-1 revealed by 19F NMR spectroscopy

1. Ruibo Zhai
2. Zhuoqi Wang
3. Zhaofei Chai
4. Xiaogang Niu
5. Conggang Li
6. Changwen Jin
7. Yunfei Hu

Pharmacological Characterization of the Endocannabinoid Sensor GRAB _eCB2.0

1. Simar Singh
2. Dennis Sarroza
3. Anthony English
4. Maya McGrory
5. Ao Dong
6. Larry Zweifel
7. Benjamin B. Land
8. Yulong Li
9. Michael R. Bruchas
10. Nephi Stella

Short-chain di-carboxylates as positive allosteric modulators of the pH-dependent pentameric ligand-gated ion channel GLIC: requirement of an intact vestibular pocket

1. Catherine Van Renterghem
2. Ákos Nemecz
3. Sandrine Delarue-Cochin
4. Delphine Joseph
5. Pierre-Jean Corringer

T1R3 subunit of the sweet taste receptor is activated by D ₂ O in transmembrane domain-dependent manner

1. Natalie Ben Abu
2. Yaron Ben Shoshan-Galeczki
3. Einav Malach
4. Masha Y. Niv

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits

1. Jong-Chan Park
2. Alex Luebbers
3. Maria Dao
4. Ana Semeano
5. Anh Minh Nguyen
6. Maria P. Papakonstantinou
7. Stefan Broselid
8. Hideaki Yano
9. Kirill A. Martemyanov
10. Mikel Garcia-Marcos

Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics

1. Basavraj Khanppnavar
2. Dina Schuster
3. Pia Lavriha
4. Federico Uliana
5. Merve Özel
6. Ved Mehta
7. Alexander Leitner
8. Paola Picotti
9. Volodymyr M Korkhov

Conformational coupling of the sialic acid TRAP transporter HiSiaQM with its substrate binding protein HiSiaP

1. Martin F. Peter
2. Jan A. Ruland
3. Yeojin Kim
4. Philipp Hendricks
5. Niels Schneberger
6. Jan Peter Siebrasse
7. Gavin H. Thomas
8. Ulrich Kubitscheck
9. Gregor Hagelueken

Accessible and Generalizable in Vitro Luminescence Assay for Detecting GPCR Activation

1. Ruby M. Miller
2. Jennifer Sescil
3. Marina C. Sarcinella
4. Ryan C. Bailey
5. Wenjing Wang

Modulated protein-sterol interactions drive oxysterol-induced impaired CXCR4 signalling

1. Anant Verma
2. Suramya Asthana
3. Deepak Kumar Saini
4. K. Ganapathy Ayappa

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel

1. Khoa Ngo
2. Diego Lopez Mateos
3. Yanxiao Han
4. Kyle C. Rouen
5. Surl-Hee Ahn
6. Heike Wulff
7. Colleen E. Clancy
8. Vladimir Yarov-Yarovoy
9. Igor Vorobyov

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

1. Elissa Moller
2. Madolyn Britt
3. Anthony Schams
4. Hannah Cetuk
5. Andriy Anishkin
6. Sergei Sukharev

Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

1. Xiaoxuan Lin
2. Patrick R Haller
3. Navid Bavi
4. Nabil Faruk
5. Eduardo Perozo
6. Tobin R Sosnick

• Curated by eLife

  eLife assessment

  This study presents important findings regarding the local dynamics at the anion binding site in the SLC26 transporter prestin that is responsible for electromotility in outer hair cells. The authors reveal critical differences to homologous proteins and thereby provide insight into prestin's unique function. The evidence is generally convincing, although orthogonal evidence would be required to fully support the claims concerning the mechanistic basis for voltage sensitivity.

Reviewed by eLife